Does Wellbutrin Feel Like Speed? (2+ Differences)

In this article, we will answer “Does Wellbutrin Feel Like Speed? We will also discuss the effects of Wellbutrin and Speed, their potential risk and safety profile, and what to do if you have overdosed on Wellbutrin.

Does Wellbutrin Feel Like Speed?

No, Wellbutrin (bupropion) does not feel like speed (methamphetamine). Currently, no research evidence suggests Wellbutrin results in similar effects like speed.

However, research reports are indicating that bupropion demonstrates similar effects to that of amphetamine-related drugs such as methylphenidate (1).

Wellbutrin (bupropion) and Speed (methamphetamine) are different substances with different mechanisms of action, but some patients have reported experiencing increased energy or stimulation while taking Wellbutrin.

What Does Research Suggest?

Bupropion is also used in the treatment of speed dependence. Furthermore, it has been reported that in animal psychopharmacology, bupropion can be fully substituted for methamphetamine in drug discrimination tests (2).

In contrast, in a clinical study, no amphetamine-like stimulant effects were observed in the dose range of 50-200 mg. Moreover, bupropion did not exhibit any autonomic or behavioural effects (1).

Always consult with a healthcare professional; for an accurate diagnosis and appropriate treatment, ensuring the safe and effective use of any medicine.

What are the key differences between Wellbutrin and Speed?

Wellbutrin moderately increases the energy levels thereby improving the overall mood and activity levels. However, speed rapidly and intensely increases energy levels which results in hyperactivity and potential psychotic and violent behaviors.

Speed intake also results in euphoria which also increases the likelihood of abuse and dependency.

Always consult a healthcare professional for appropriate prescriptions and use of these substances to avoid adverse effects and complications.

Mechanism of Action of Wellbutrin (Bupropion):

Wellbutrin contains bupropion which is an antidepressant drug that acts by inhibiting the reuptake of norepinephrine and dopamine, enhancing their levels in the brain. It is an FDA-approved drug for the treatment of the following conditions (3):

  • Adult depression
  • Seasonal affective disorder
  • Smoking cessation

The off-label uses of Wellbutrin include anti-depressant-induced sexual dysfunction, attention-deficit/hyperactivity disorder (ADHD), depression associated with bipolar disorder, and obesity (3).

Mechanism of action of Speed (Methamphetamine):

Speed contains methamphetamine that acts on the central nervous system by enhancing the levels of dopamine, norepinephrine, and serotonin (4).

The use of methamphetamine results in increased levels of alertness, mood, elevated levels of energy and concentration, as well as enhanced sexual libido (4). It is primarily used in the treatment of ADHD and obesity; however, speed is better known as a recreational drug.

Side effects of Wellbutrin (Bupropion) 

The potential side effects of the use of Wellbutrin are as follows:

Side Effects of Speed (Methamphetamine)

Individuals who engage in the consumption of speed experience a transient and intense surge of euphoria lasting between 5 to 30 minutes with the duration being contingent upon the specific method of administration employed (4).

Additionally, speed induces heightened levels of energy, and suppresses appetite. and elicits feelings of euphoria for a duration spanning from 6 to 12 hours (4).

The potential side effects of speed (methamphetamine) are as follows (4):

Short-term side effects:

  • Decreases appetite
  • Nausea
  • Psychosis
  • Tachycardia
  • Hypertension
  • Increased body temperature
  • Panic attack
  • Mydriasis (dilation of pupils)
  • Disturbed sleep patterns
  • Violent, bizarre, and erratic behaviour
  • Hallucinations and irritability
  • Seizures, convulsions, and death from high doses

Prolonged methamphetamine use can lead to extensive cardiovascular damage, organ failure, dental decay, and tissue damage depending on the method of ingestion.

It increases the risk of infectious diseases (when injected), respiratory issues (when smoked), and severe psychological issues, including dependence, psychosis, and depression.

Additionally, it can cause significant weight loss, malnutrition, and irreversible harm to brain structures resembling conditions like Alzheimer’s disease, epilepsy, and stroke.

Safety Profile of Wellbutrin and Speed

Wellbutrin is known for its low abuse and dependency profile. It is often prescribed with a regulated dose to mitigate side effects and ensure safety.

In contrast, Speed has a significant risk of abuse and dependency due to its intense euphoric and energizing effects (4).

Wellbutrin Overdose:

An overdose of Wellbutrin (Bupropion) is a medical emergency and requires immediate attention. Here’s what you should do:

  • Seek a healthcare professional immediately.
  • Keep calm, and if possible, try to gather information about the quantity and time of Wellbutrin ingested to inform the emergency responders.
  • Do not self-treat.
  • Monitor symptoms such as hallucinations, rapid heartbeat, or seizures.

Can you take Wellbutrin and Speed together?

Taking Wellbutrin (bupropion) and Speed (Methamphetamine) is highly dangerous and strongly discouraged. Both drugs are stimulants that affect the neurotransmitters in the brain, but they work in different ways.

When taken together, they can increase the risk of severe side effects and potentially life-threatening conditions.

If you or someone else is considering or currently taking speed and Wellbutrin together, it is crucial to seek medical advice and intervention immediately.


In this article, we have successfully addressed the question “Does Wellbutrin Feel Like Speed”. We have also discussed the major differences between Wellbutrin and Speed in terms of their mechanism of action, safety profile, and what to do if you have overdosed on Wellbutrin to achieve speed-like effects.

Was this helpful?

Thanks for your feedback!



Chevassus, H., Farret, A., Gagnol, JP. et al. Psychological and physiological effects of bupropion compared to methylphenidate after prolonged administration in healthy volunteers (NCT00285155). Eur J Clin Pharmacol 69, 779–787 (2013).


Munzar P, Goldberg SR (2000) Dopaminergic involvement in the discriminative-stimulus effects of methamphetamine in rats. Psychopharmacology (Berl) 148(2):209–216


Huecker MR, Smiley A, Saadabadi A. Bupropion. [Updated 2023 Apr 9]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2023 Jan-. Available from:


Yasaei R, Saadabadi A. Methamphetamine. [Updated 2023 May 1]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2023 Jan-. Available from:

Find a supportive therapist who can help with Depression.

Discover the convenience of BetterHelp, an online therapy platform connecting you with licensed and accredited therapists specialized in addressing issues such as depression, anxiety, relationships, and more. Complete the assessment and find your ideal therapist within just 48 hours.


AskYourPharm is user-supported. We may earn a commission if you sign up for BetterHelp’s services after clicking through from this site