Are Wellbutrin-induced tremors permanent? 

In this brief article, we are going to answer the question “Are Wellbutrin-induced tremors permanent?” as well as some other topics related to this subject. 

Are Wellbutrin-induced tremors permanent? 

‌No, tremors induced by Wellbutrin are not permanent, and they tend to improve after a few weeks of discontinuing the medication. Tremors are observed in approximately 20% of individuals taking this antidepressant, and they may also be associated with other antidepressants (1,2).

However, it is not a universal occurrence as each individual may respond differently to Wellbutrin. Some individuals may experience mild tremors in their limbs, face, or eyes, which gradually diminish as the body adapts to the medication (3).

What does research suggest?

There are a number of research studies indicating that tremors are one of the potential side effects of Wellbutrin (3,5). 

One study published in the Journal of Clinical Psychopharmacology and Neuroscience in 2015 indicated that Wellbutrin can cause tardive dyskinesia, which is an extrapyramidal side effect (1). 

It is quite rare but can trigger symptoms like tremors and abnormal movement of facial muscles. 

Another research evaluated this drug in 20 patients with idiopathic Parkinson’s disease. The study concluded that Wellbutrin  is mildly efficacious in Parkinson’s disease, although side effects were frequent and were dose-limiting in five patients (4).

Two  case studies involved patients with Wellbutrin-induced acute dystonia. This condition can cause involuntary muscle movements in such patients. Although the incidence of this side effect is low, it can still be pretty nerve-racking (1,2). 

These studies indicate that tremors can be triggered by Wellbutrin either directly, or the drug can exacerbate pre-existing tremors (6). It is essential to discuss your side effects with your doctor for proper management of your symptoms and dose adjustment. 

 What are some factors that may affect the duration of tremors?

There are some factors that may affect the duration of tremors in some people. These include:

• Dosage strength – higher doses take longer for people to adjust to and can cause prolonged side effects (1).
• Pre-existing medical conditions – people who already have a health condition that causes tremors may experience more pronounced tremors while taking Wellbutrin (6).
• Patient-specific factors – the severity and duration of tremors can vary among individuals. Age, overall health, and other medications being taken can all impact the body’s response to Wellbutrin and the development of tremors (6).
• Alcohol use: Drinking alcohol while taking Wellbutrin may increase the likelihood of developing tremors or prolong the duration of existing tremors, and can also increase the risk of other Wellbutrin-induced side effects like dizziness, tiredness, vomiting, etc (8).
• Genetic factors: Some research suggests that certain genetic factors may make individuals more susceptible to developing tremors while taking Wellbutrin, which may impact the duration of the tremors (7).

How do Wellbutrin-induced tremors go away? 

Mild tremors induced by Wellbutrin may improve over time (2). However, in most cases, discontinuing the medication is necessary as tremors persist while taking it.

If you are a new user of Wellbutrin experiencing mild tremors, your doctor may not immediately discontinue the medication.

In such cases, dose reduction allows your body to adjust to Wellbutrin, leading to eventual improvement of the tremors and continuation of the antidepressant treatment.

In routine practice, persistent tremors indicate that the antidepressant is not suitable for you, and healthcare providers typically transition such patients to an alternative antidepressant. It is important to report your tremors to your healthcare provider.

Antidepressants including SSRIs like Zoloft, Lexapro, etc have a different mechanism of action compared to Wellbutrin, but these antidepressants may also cause tremors.

It is strongly advised not to abruptly stop antidepressants, including Wellbutrin or any other medication. Abrupt discontinuation can result in distressing symptoms, and such medications should always be tapered off if they are negatively impacting your health.

Is it possible to reduce the wellbutrin-induced tremors?

No, lifestyle changes and exercise are unlikely to directly reduce Wellbutrin-induced tremors. These tremors are primarily caused by the effects of Wellbutrin on the central nervous system (3).

However, engaging in regular exercise and maintaining a healthy lifestyle can contribute to overall physical and mental well-being, which may indirectly help manage some side effects of Wellbutrin, including tremors. 

Exercise, particularly activities that promote relaxation and stress reduction such as yoga or meditation, may help alleviate general anxiety and promote a sense of calmness (9).

Remember, lifestyle changes and exercise should always be discussed with your healthcare provider as part of a comprehensive treatment plan, and they should not replace medical advice or adjustments to medication dosage.

Conclusions

This concise article addressed the question “Are Wellbutrin-induced tremors permanent?” and provided an explanation of factors that may influence the duration of tremors, as well as how they can subside. Additionally, a brief guide was provided on potential indirect methods to reduce Wellbutrin-induced tremors.

References