Does Wellbutrin-induced constipation go away? 

Does Wellbutrin-induced constipation go away? 

Yes, Wellbutrin-induced constipation does start to get better within a few weeks of your treatment, as your body adjusts to the medication. People who are healthy can take some constipation aids to help relieve this problem. 

However, it’s best to consult your doctor if you have haemorrhoids or anal fissures, and Wellbutrin-induced constipation is making these conditions even more painful than they already are. 

Meds affect people differently, and generally, constipation is not something people worry much about. 

What does research suggest? 

Research studies indicate that constipation is a commonly reported side effect of Wellbutrin. The extended-release or sustained-release dosage forms are more commonly associated with it and can trigger severe constipation in some cases (1,2).

Other studies suggest that Wellbutrin is a dehydrating antidepressant which can cause your bowel to be harder – as lack of enough hydration in your body can dry out your intestines and affect their motility. 

This also causes your stools to remain in your large intestine for a longer period of time. When your body is dehydrated, your intestines keep absorbing water from your stools, which start to get harder and harder. 

This affects your bowel movement significantly and even healthy individuals suffer to get the hard faeces out of their bodies. 

Prolonged hard stools or chronic constipation can cause piles and a tear in your anal muscles – known as anal fissures. These conditions can be quite painful and can affect the quality of your life (3,4). 

How to get rid of Wellbutrin-induced constipation? 

There are a few things you can do to get rid of Wellbutrin-induced constipation fast. These are (5). 

  • Drink plenty of water. 
  • Take an OTC laxative 
  • Increase your fibre intake or take a supplement if you can’t get enough fibre through your diet. 
  • Take Wellbutrin with meals. 
  • Make exercise a part of your routine. 
  • Take a tablespoon of extra virgin olive oil to relieve constipation. 
  • Eat lots of fruits and vegetables. 
  • Apply mustard oil on your anal opening if you’re about to pass a hard stool. This will help prevent the stool from causing a tear in your muscles, and it will slip out causing less pain. 

It’s always best to discuss your side effects with your healthcare provider to determine the future safety and efficacy of an antidepressant. 

Wellbutrin is generally well tolerated, but it may not be the best antidepressant for every other individual or may not work well for everyone. Make sure you don’t stop taking Wellbutrin without your doctor’s approval. 

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Lounsbery JL, Medow MA, Green CG. Severe constipation is associated with extended-release bupropion therapy. Am J Health Syst Pharm. 2008 Aug 15;65(16):1530-2. doi: 10.2146/ajhp070486. PMID: 18693207.


Fava M, Rush AJ, Thase ME, Clayton A, Stahl SM, Pradko JF, Johnston JA. 15 years of clinical experience with bupropion HCl: from bupropion to bupropion SR to bupropion XL. Prim Care Companion J Clin Psychiatry. 2005;7(3):106-13. doi: 10.4088/pcc.v07n0305. PMID: 16027765; PMCID: PMC1163271.


Camilleri M, Ford AC, Mawe GM, Dinning PG, Rao SS, Chey WD, Simrén M, Lembo A, Young-Fadok TM, Chang L. Chronic constipation. Nat Rev Dis Primers. 2017 Dec 14;3:17095. doi: 10.1038/nrdp.2017.95. PMID: 29239347.


Forootan M, Bagheri N, Darvishi M. Chronic constipation: A review of literature. Medicine (Baltimore). 2018 May;97(20):e10631. doi: 10.1097/MD.0000000000010631. PMID: 29768326; PMCID: PMC5976340.


Jani B, Marsicano E. Constipation: Evaluation and Management. Mo Med. 2018 May-Jun;115(3):236-240. PMID: 30228729; PMCID: PMC6140151.

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