How do you know if Wellbutrin is working? 

How do you know if Wellbutrin is working? 

You’ll know your Wellbutrin is working for depression if it causes the following effects:

  • You feel like yourself again
  • Your eating patterns are going back to normal.
  • You’re sleeping well. 
  • You feel high on energy and motivation 
  • You have a more positive mindset 

You feel like yourself again

The biggest impact of depression is detachment from one’s own self. This mental health condition makes you hopeless and worthless, which can affect your entire personality with time. 

If you’re taking Wellbutrin and it’s working on you, you will begin to feel more attached to yourself. You’ll feel that self-love and will surely start to see your worth again. 

You don’t find the activities you love a burden on you anymore. Work will start to seem less problematic, and you will feel confident in yourself and in front of other people. 

Your eating patterns are going back to normal

Depression is well known to affect your eating patterns. Some people lose their appetite as they struggle with depression, whereas some people begin to binge eat. 

These irregular eating patterns can lead to weight loss or gain, which can also affect your mental health. When Wellbutrin starts to work, you begin to observe your eating patterns going back to normal. 

People who used to overeat will start to notice a decrease in their cravings, and people who lost their appetites will begin to find food more desirable. Wellbutrin may cause some appetite-related side effects during the early course of your treatment, but they don’t usually stay. 

You’re sleeping well

Depression can also damage healthy sleep patterns in almost every person it affects. Some people may struggle with insomnia, as their thoughts keep them up all night long. 

Some other people may experience somnolence or hypersomnia, and they fall into a deep sleep – no matter if it’s the middle of the day. Wellbutrin starts to normalize such sleeping patterns when it starts to work. 

Some people may struggle with insomnia during the early course of their treatment, but it gets better as your body adjusts and taking Wellbutrin in the morning can also help. 

However, once your body is fully adjusted and Wellbutrin kicks in, you’ll find your sleep patterns going back to normal. 

You feel high on energy and motivation 

Wellbutrin is known as the best antidepressant for energy and motivation. It may make you tired during the early course of your treatment, but it eventually increases the amount of norepinephrine and dopamine in your brain – which are two excitatory neurotransmitters. 

This elevates your mood, boosts your energy levels and motivation, makes you more productive, and frees you from the nerve-racking fatigue of depression. 

You have a more positive mindset 

When Wellbutrin starts to work, you find your mindset getting more positive by the day. This is because depression makes you suicidal and even a minor inconvenience makes you think that everything is falling apart. 

This mindset and negative perception start to change when Wellbutrin kicks in. You begin to tackle your daily life problems more positively and small things don’t seem to upset you anymore. 

What to do if you feel your Wellbutrin isn’t working? 

Talk to your healthcare provider if you fail to notice a positive change in your depression symptoms after weeks of using Wellbutrin. It’s a known fact that Wellbutrin takes some time to work, more for some people compared to others. 

However, it does start to normalise your sleep quality, eating patterns, and energy levels within 2 weeks. If you don’t feel better within 4-6 weeks, talk to your doctor. Wellbutrin is overall a good antidepressant, but it may not be the best one for every other individual. 

If it’s not working well enough for you, your doctor may escalate your dose or switch you to another antidepressant. Make sure you don’t stop using Wellbutrin without consulting your doctor first. 

Abrupt Wellbutrin withdrawal can lead to disturbing symptoms, such as mood changes, flu-like symptoms, unusual weight changes, brain zaps, increased risk of relapse, etc.

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MedlinePlus. Bupropion [Internet]. Bethesda (MD): National Library of Medicine (US); [updated 2022 Apr 15; cited 2023 Feb 28]. Available from:

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