Does Wellbutrin cause muscle twitching? (3+ factors)

In this article, we will discuss muscle twitching associated with Wellbutrin. We will also talk about what are the causes of muscle twitching and what should you do if this side effect occurs.

Does Wellbutrin cause muscle twitching?

Yes, muscle twitching is a potential side effect of Wellbutrin but it is rare(4). Muscle twitching can be described as sudden, involuntary muscular contractions. These contractions can happen anywhere in the body and usually occur as swift, short motions. Muscle twitching may occur before or after, starting or changing the dosage.

What does research suggest?

According to research and clinical data, the majority of patients do not typically experience the muscle-twitching side effect of Wellbutrin. Few patients have reported involuntary head and neck muscle contractions. It may also be linked with jaw clenching, bruxism and temporomandibular syndrome (TMJ) (2).

The possibility that few patients will experience this side effect varies from person to person. For those who do, though, it could be disturbing and upsetting because it affects their lifestyle.

It may also depend upon several factors, including the patient’s sensitivity to the medicine and the dose they are consuming regularly. Some people may be allergic to Wellbutrin and experience reactions like hives, skin rash, itching, patches or blisters which might be painful too.

If you see any of such reactions, immediately seek medical help. However, there is limited data available on the muscle twitching side effect of Wellbutrin. There are other reported side effects of Wellbutrin as well including(1):

What are the causes of muscle twitching with Wellbutrin?

Alteration of neurotransmitters

Muscle twitching, which might occur after intake of antidepressants, may be associated with Wellbutrin, because it affects the brain neurotransmitters, mainly norepinephrine and dopamine, which may result in the alteration of these chemical substances in the brain.

These modifications may have an impact on muscle control and can be a factor in some individuals for triggering muscle twitching. It also increases alertness by stimulating the central nervous system. Due to this effect, few patients may experience muscle twitching.

Reactions to medicines might differ significantly in different people. Due to their specific physiological responses to Wellbutrin, all patients will not be affected by the same side effects. Certain people may be more prone to some adverse effects after intake of Wellbutrin including muscular twitching.

Drug-dose relationship and other medical illnesses

There might also be a possible drug-dose relationship (3,4) between the likelihood of experiencing muscle twitching as a Wellbutrin adverse effect. Some people may be more susceptible to muscular twitching when given higher doses of Wellbutrin.

The occurrence of symptoms varies in patients depending on the drug-dose relationship. Taking certain drugs or supplements at the same time as Wellbutrin may make you more likely to muscular twitch. To avoid drug interactions, please let your healthcare provider know about all the drugs and supplements you take.

Medical illnesses other than drug interactions might also cause muscle twitching. Your healthcare professional must make sure all other possibilities are eliminated before deciding whether Wellbutrin is the real reason behind your twitching muscles.

Tips to manage Wellbutrin-induced muscle twitching

It’s important to talk to your doctor if you experience muscle twitching while consuming Wellbutrin. They will assess your symptoms, look for the possible contributing factors, and choose the best course of action, which might involve the following:

  • Adjusting the dosage of Wellbutrin as per your need.
  • Shifting to a different antidepressant drug that may not have such an undesirable side effect.
  • Keep yourself well hydrated.
  • Get enough quality sleep.
  • Engage yourself in stress reduction exercises like yoga or meditation.
  • Keep track of your twitching episodes to find patterns and possible triggers.
  • Getting a second opinion from a neurologist, to rule out any underlying neurological disorders.


Even though Wellbutrin’s side effect of muscle twitching is rather uncommon, it is critical to be aware of the risk if you are taking this medicine. Immediately seek professional help if you notice any side effects, including muscle twitching, while taking Wellbutrin.

The common factors causing muscle twitching may be Wellbutrin affecting the brain neurotransmitters, different physiological responses among patients, possible drug interactions or any other underlying medical condition. These conditions should be openly discussed with your doctor so they can examine your condition and adjust the dosage accordingly.

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Huecker MR, Smiley A, Saadabadi A. Bupropion. 2023 Apr 9. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2023 Jan–. PMID: 29262173. Available from: 




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