Does Wellbutrin cause heartburn? 

Does Wellbutrin cause heartburn?

Wellbutrin may cause heartburn in some individuals. Although it is not that common with Wellbutrin, people do report heartburn every now and then. 

This side effect is more common in people who are new to Wellbutrin or antidepressants in general, and it does begin to subside as your body adjusts to it. 

If your heartburn with Wellbutrin gets severe, or you already have ulcers in your stomach or you suffer from gastroesophageal reflux disease (GERD), reach out to your healthcare provider as soon as you can. 

The incidence of heartburn with Wellbutrin 

The incidence of heartburn with Wellbutrin varies among individuals, and research on this specific side effect is limited. The exact mechanism by which Wellbutrin may contribute to heartburn is not fully understood (1,2).

It is believed that Wellbutrin can affect the gastrointestinal tract, including the lower esophageal sphincter (LES), which is a muscle that helps prevent stomach acid from flowing back into the esophagus. Disruption of the LES function can lead to acid reflux and heartburn symptoms.

It’s important to note that many factors can contribute to heartburn, including lifestyle choices, diet, and underlying medical conditions. It’s possible that some individuals may experience heartburn coincidentally while taking Wellbutrin, but the medication may not be the direct cause.

What to do if Wellbutrin causes heartburn? 

Wellbutrin-induced heartburn is usually not a concerning side effect and it starts to go away as your body adjusts to this antidepressant. However, you can try some things to reduce the symptoms and find some relief. Let’s look at a few important tips. 

  • Take an OTC acid reducer, like Omeprazole early in the morning on an empty stomach for a few days until your body adjusts to Wellbutrin. 
  • Do not take Wellbutrin on an empty stomach. If yours is a morning dose, take it in between your breakfast.
  • Avoid trigger foods, like heavy foods in general or overly spicy foods.
  • Do not drink coffee excessively while taking Wellbutrin
  • Drink plenty of water. 
  • Take Probiotics to improve your stomach health. 

If your heartburn on Wellbutrin is severe or is paired with other unbearable side effects, reach out to your healthcare provider. Wellbutrin is overall a well-tolerated antidepressant, but it may not suit everyone. 

If Wellbutrin is not the right choice of antidepressant for you, your doctor may switch you to another one. Make sure you don’t stop using Wellbutrin without your doctor’s approval. 

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Huecker MR, Smiley A, Saadabadi A. Bupropion. 2023 Apr 9. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2023 Jan–. PMID: 29262173.


Oliva V, Lippi M, Paci R, Del Fabro L, Delvecchio G, Brambilla P, De Ronchi D, Fanelli G, Serretti A. Gastrointestinal side effects associated with antidepressant treatments in patients with major depressive disorder: A systematic review and meta-analysis. Prog Neuropsychopharmacol Biol Psychiatry. 2021 Jul 13;109:110266. doi: 10.1016/j.pnpbp.2021.110266. Epub 2021 Feb 5. PMID: 33549697.

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