Does Lexapro cause migraines? (3+causes)

In this article, we will discuss whether Lexapro can cause migraines. While it is true that Lexapro can trigger headaches in certain individuals, it is important to remember that the response to this medication varies from person to person.

Does Lexapro cause migraines?

Yes, Lexapro can potentially cause migraines in some individuals. However, it is important to note that everyone’s reaction to the medication is different. If you are experiencing migraines while on Lexapro, it is crucial to consult your healthcare provider.

Lexapro, or escitalopram is a selective serotonin reuptake inhibitor (SSRI) used for treating depression and anxiety; however, it can cause side effects, including migraines (1). Migraines are intense headaches that can be triggered by various factors, including medications (1).

Headaches are a more general term that encompasses unpleasant pains in your head that can cause pressure and aching. On the other hand, migraines are a neurological disorder characterised by moderate to severe headaches, usually on one side of the head. 

While headaches are commonly reported as a side effect of Lexapro, anecdotal evidence suggests that some people experience migraines as a side effect of taking Lexapro. However, these reports are subjective and should be taken with caution. 

What is the connection between Lexapro and migraine?

The relationship between Lexapro and migraine is complex and not entirely understood. While Lexapro does not directly cause migraines, some individuals may experience them as a side effect. Some studies suggest a possible connection due to changes in serotonin levels caused by Lexapro (3). However, these findings are not conclusive.

Several factors may contribute to migraines in Lexapro users (4):

  • Initial adjustment: when initiating Lexapro, the brain changes as serotonin levels are modified. These adjustments can sometimes lead to side effects, including mild headaches. Fortunately, these initial headaches typically subside as the body adapts to the medication.
  • Dose-related effect: The likelihood of experiencing headaches may be dose-dependent. Higher doses of Lexapro may increase the risk of side effects, including migraines, compared to lower doses.
  • Individual variability: People react differently to medications, and some individuals may be more susceptible to experiencing migraines as a side effect of Lexapro, while others may not experience them at all.
  • Serotonin syndrome: This is a rare but potentially serious condition that can result from excess serotonin.
  • Drug interactions: certain medications may interact with Lexapro, leading to an increased risk of migraine.

Tips for managing migraines while on Lexapro

To manage migraines while on Lexapro, consider taking your medication with food, staying well hydrated, and maintaining a healthy lifestyle through a balanced diet, adequate rest, and regular exercise.

If you are experiencing migraines while on Lexapro, consult your healthcare provider.  Strategies for managing Lexapro-induced migraines include (5):

  • Adjusting your dose level: Your doctor might consider adjusting your Lexapro dose to minimize side effects, including migraines.
  • Identifying migraine triggers: Recognizing and avoiding migraine triggers such as specific foods, stress, or lack of sleep can help reduce the frequency and severity of migraines.
  • Using over-the-counter painkillers: Over-the-counter pain relievers may help alleviate migraine symptoms. However, it is crucial to consult your healthcare provider before taking any new medication, as they may interact with Lexapro.
  • Monitoring and reporting: Keeping a headache diary to record migraines, their intensity, and potential triggers is valuable. Share this information with your healthcare provider to help tailor your treatment plan.

What are your options if Lexapro migraines are intolerable?

If you are unable to tolerate Lexapro due to migraines , there are other treatment options available. These may include other types of antidepressants, psychotherapy, lifestyle changes, or complementary therapies like acupuncture or meditation.

Always consult your healthcare provider if you have concerns about your medication or if you are experiencing side effects like migraines. They can provide personalised responses based on your specific situation and health history.

Final words

While some people may experience migraines while taking Lexapro, it is important to note that everyone’s reaction to medication is different. If you are concerned about migraines or any other side effects from Lexapro, speak to your healthcare provider. They can help weigh the benefits and risks of continuing with the medication or explore alternative treatment options.

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References

1.-

aWaugh J, Goa KL. Escitalopram : a review of its use in the management of major depressive and anxiety disorders. CNS Drugs. 2003;17(5):343-62. doi: 10.2165/00023210-200317050-00004. PMID: 12665392. https://pubmed.ncbi.nlm.nih.gov/12665392/

2.-

Evans RW. The FDA alert on serotonin syndrome with combined use of SSRIs or SNRIs and Triptans: an analysis of the 29 case reports. MedGenMed. 2007 Sep 5;9(3):48. PMID: 18092054; PMCID: PMC2100123. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2100123/

3.-

Banzi R, Cusi C, Randazzo C, Sterzi R, Tedesco D, Moja L. Selective serotonin reuptake inhibitors (SSRIs) and serotonin-norepinephrine reuptake inhibitors (SNRIs) for the prevention of migraine in adults. Cochrane Database Syst Rev. 2015 Apr 1;4(4):CD002919. doi: 10.1002/14651858.CD002919.pub3. PMID: 25829028; PMCID: PMC6513227. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6513227/

 

4.-

Holroyd KA, O’Donnell FJ, Stensland M, Lipchik GL, Cordingley GE, Carlson BW. Management of chronic tension-type headache with tricyclic antidepressant medication, stress management therapy, and their combination: a randomized controlled trial. JAMA. 2001 May 2;285(17):2208-15. doi: 10.1001/jama.285.17.2208. PMID: 11325322; PMCID: PMC2128735. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2128735/

5.-

D’Amico D, Tepper SJ. Prophylaxis of migraine: general principles and patient acceptance. Neuropsychiatr Dis Treat. 2008 Dec;4(6):1155-67. doi: 10.2147/ndt.s3497. PMID: 19337456; PMCID: PMC2646645. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2646645/

 

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