Can Citalopram cause night sweats? (3+ drugs that can help)

In this article, we will discuss Citalopram-induced night sweats and what research studies suggest about it. We will also discuss potential treatments for excessive sweating.

Can Citalopram cause night sweats?

Yes, using Citalopram (Celexa) can cause night sweats or increased sweating. It is one of the most common side effects of using this drug.

It is important to understand that every individual is different, and not everyone will experience these side effects. Some may experience excessive sweating, and some may not experience any increased sweating at all.

Other antidepressants such as Sertraline, Effexor, Wellbutrin, Pristiq, and Lexapro are also known to cause night sweats, increased sweating, or sweaty hands.

What does research suggest?

Several studies have been conducted to examine the link between selective serotonin reuptake inhibitors (SSRIs) and sweating. 7% to 19% of the patients using SSRIs experience increased sweating as a side effect. (1)

In one study, it was reported that only 38 out of 415 participants experienced night sweats. It was also revealed that gender, age, BMI and the total number of medications taken on a regular basis were not related to night sweats. (1)

However, after adjusting for age and gender, it was found that angiotensin receptor blockers (ARBs), thyroid hormone supplements, and SSRIs were the only classes of drugs that were linked with night sweats. (1)

What are the possible treatments for Citalopram-induced night sweats?

Various studies discuss the potential treatments for night sweats or excessive sweating caused by antidepressants.

In five case reports, it was reported that Cyproheptadine, which is an antihistamine and also a serotonin antagonist, decreased night sweats. It was most likely caused by the serotonin antagonist activity of the drug. (2)

It was also found that the use of Cyproheptadine as a treatment for SSRI-induced sweating decreased excessive sweating without any changes in the efficacy of SSRI treatment. (2)

One study reported that the use of Terazosin, a long-acting selective alpha-1 adrenergic receptor blocker, significantly improved the daytime and nighttime severity of sweating. Twenty-two of the twenty-three participants responded well to Terazosin. (3)

However, dizziness and lightheadedness were reported as the most common side effects of the Terazosin therapy. The therapy was generally well tolerated aside from these side effects, and no patients dropped out due to this.

In another study, 140 patients suffering from major depressive disorder were being treated with Sertraline, an SSRI. These patients received Oxybutynin, an anticholinergic drug, to see how it affected the excessive sweating caused by the antidepressant. (4)

It was concluded that the use of Oxybutynin in treating SSRI-induced excessive sweating was successful. It was also found that the female patients reported less sweating compared to the male patients. (4)

Benztropine, another anticholinergic, can be used in the treatment of antidepressant-induced excessive sweating. Patients using Benztropine experienced the benefits of the drug within one hour of administration. (5)

What to do if Citalopram-induced night sweats persist?

If Citalopram-induced night sweats persist, please inform your doctor immediately. Your doctor might reduce your dose to see if your side effects improve. Research suggests that dose reduction might help in reducing antidepressant-induced excessive sweating. (6)

If lowering the antidepressant dose improves this side effect, your doctor may gradually increase the dose later and find the right balance for you.

However, if dose reduction is not effective, your doctor might consider switching to another antidepressant if you still experience night sweats or excessive sweating.

Your doctor might prescribe medications such as Cyproheptadine, Terazosin, Oxybutynin, and Benztropine as additive therapy for treating antidepressant-induced night sweats or excessive sweating.

It is very important to understand that your doctor will determine which drug is appropriate for treating your sweating symptoms based on your health condition, as long as there are no adverse reactions between them. Never start taking any drug without consulting your doctor.


In this article, we have discussed whether Citalopram causes night sweats, what research tells us about it, and what potential treatments for it are. We also discussed what to do if Citalopram-induced night sweats persist.

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Mold JW, Holtzclaw BJ. Selective Serotonin Reuptake Inhibitors and Night Sweats in a Primary Care Population. Drugs Real World Outcomes. 2015 Mar;2(1):29-33. doi: 10.1007/s40801-015-0007-8. PMID: 27747615; PMCID: PMC4883206. Avaiable from:



Ashton AK, Weinstein WL. Cyproheptadine for drug-induced sweating [Internet]. The American Journal of Psychiatry. 2022 1 May. Avalable from:


Mago R, Thase ME, Rovner BW. Antidepressant-induced excessive sweating: clinical features and treatment with terazosin. Ann Clin Psychiatry. 2013 Aug;25(3):186-92. Epub 2013 May 1. PMID: 23638448. Available from:


Ghaleiha A, Jahangard L, Sherafat Z, Ahmadpanah M, Brand S, Holsboer-Trachsler E, Bajoghli H, Haghighi M. Oxybutynin reduces sweating in depressed patients treated with sertraline: a double-blind, placebo-controlled, clinical study. Neuropsychiatr Dis Treat. 2012;8:407-12. doi: 10.2147/NDT.S36329. Epub 2012 Sep 14. PMID: 23028229; PMCID: PMC3446858. Available from:


Kolli V, Ramaswamy S. Improvement of antidepressant-induced sweating with as-required benztropine. Innov Clin Neurosci. 2013 Nov;10(11-12):10-1. PMID: 24563813; PMCID: PMC3931183. Available from:


Marcy TR, Britton ML. Antidepressant-induced sweating. Ann Pharmacother. 2005 Apr;39(4):748-52. doi: 10.1345/aph.1E564. Epub 2005 Feb 22. PMID: 15728327. Available from:

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