Does Pristiq cause night sweats? 

Does Pristiq cause night sweats? 

Yes, Pristiq does cause night sweats in 10-15% of the population taking this antidepressant. In fact, a huge number of antidepressants are associated with this side effect, and not just night sweats – but sweating in general. 

If it’s one of the early side effects of Pristiq, it’s most likely to subside within a few weeks of your treatment as your body adjusts to the medication. 

However, Pristiq may cause excessive, unbearable sweating and exhaustion in some people, which can affect the quality of their lives. 

Why does Pristiq cause night sweats or sweating in general? 

Pristiq is an antidepressant that increases the amount of serotonin and norepinephrine in your brain, which are two excitatory monoamine neurotransmitters. 

These chemicals can affect your hypothalamus, the part of your brain that plays an important role in regulating your body temperature and it also controls your ability to sweat. 

This is why Pristiq and some other antidepressants can increase your body temperature and trigger sweating, as your body tries to release excess heat. 

However, antidepressants don’t affect everyone in the same way and some people may not experience sweating on these meds. 

What to do if Pristiq causes night sweats? 

Talk to your healthcare provider if Pristiq causes night sweats. Most people get better with time as their bodies adjust to the antidepressant, but some people may not recover from this side effect while taking the medication. 

In some cases, the doctor may recommend not taking Pristiq at night to reduce the intensity of this side effect. However, most doctors try dose reduction which does work well, especially for new users but some people suffer from severe depression and dose reduction is not really suitable for them. 

In case of excessive sweating, your doctor may prescribe you Terazosin, an alpha-1 adrenergic antagonist which can actively control excessive sweating (1). 

A study published in the Journal of Innovations in Clinical Neuroscience indicated that Benztropine can help reduce the intensity of excessive sweating caused specifically by antidepressants (2). The exact dose was not stated, but it’s recommended to take the medication as needed.

However, make sure you don’t start using any medication with Pristiq without consulting your doctor first. 

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Mago R, Thase ME, Rovner BW. Antidepressant-induced excessive sweating: clinical features and treatment with terazosin. Ann Clin Psychiatry. 2013 Aug;25(3):186-92. Epub 2013 May 1. PMID: 23638448. Available from:


Kolli V, Ramaswamy S. Improvement of antidepressant-induced sweating with as-required benztropine. Innov Clin Neurosci. 2013 Nov;10(11-12):10-1. PMID: 24563813; PMCID: PMC3931183. Available from:

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