Does citalopram deplete magnesium? (+5 factors)

In this article, we will discuss whether citalopram affects magnesium levels in the body. We will also discuss the research studies linking the use of citalopram to the depletion of magnesium. Additionally, we will discuss the factors that may increase the risk of citalopram-induced hypomagnesemia. We will also discuss the management of hypomagnesemia if it occurs while taking citalopram. 

Does citalopram deplete magnesium?

Yes, citalopram can deplete magnesium. Electrolyte imbalance is the common side effect of various antidepressant medications including citalopram. Various research studies have demonstrated the occurrence of hypomagnesemia while taking this medication.

However, it is important to note that individual responses to medication may vary and some individuals may not experience this side effect of citalopram.

Citalopram, in general, is an antidepressant medication that is commonly employed in the management of various mental health conditions such as depression, anxiety, and obsessive-compulsive disorder. While it is considered a safe medication, it may cause side effects in susceptible patients (1). 

What does research suggest?

Research shows that citalopram use can lead to a depletion of magnesium and potassium levels in patients. It is important to monitor these electrolyte levels before starting citalopram treatment to prevent serious complications (1). 

The Food and Drug Administration (FDA) warns that citalopram can cause hypomagnesemia, which increases the risk of cardiovascular issues like arrhythmias or QT prolongation. To prevent these side effects, the FDA recommends monitoring electrolyte levels both before and during citalopram treatment (2).

What factors may influence citalopram-induced hypomagnesemia?

Various factors may increase the risk of depletion of magnesium and other electrolytes while using citalopram. Some of these factors may include the following: 

What to do if citalopram causes hypomagnesemia?

If you experience symptoms of hypomagnesemia such as fatigue, muscle cramps, numbness, palpitations, or nausea after using citalopram, you should immediately consult your healthcare provider. 

Your healthcare provider will assess your symptoms and test your magnesium levels. If your symptoms are associated with hypomagnesemia caused by citalopram, your healthcare provider may recommend some magnesium-containing supplements or dietary changes.

However, in cases of severe hypomagnesemia, your healthcare provider may make changes in your treatment plan by adjusting the dosage or discontinuation of citalopram.

It is important to note that the decision to discontinue citalopram should be based on the overall risks and benefits of the therapy. 

How to manage citalopram-induced hypomagnesemia?

To overcome the magnesium deficiency, your healthcare provider may recommend you consider the following management tips:

• Increase magnesium-rich foods in your diet, such as leafy green vegetables, seeds, and legumes. 
• Excessive alcohol consumption can contribute to magnesium loss. Moderate your alcohol intake. 
• Maintain proper hydration levels, as dehydration can exacerbate magnesium imbalance.
• If recommended by a healthcare professional, take magnesium supplements as prescribed.
• Consider magnesium glycinate as it has high absorption and may be gentler on the stomach.
• A healthy digestive system aids in magnesium absorption. Consider probiotics or prebiotics. 

In my experience

In my experience, patients do report the symptoms of electrolyte imbalances after using antidepressants including citalopram. In such cases, healthcare providers usually recommend dietary changes or they may prescribe magnesium-containing supplements for maintaining the optimum magnesium levels of the patients. 

References