What is the best time of day to take Paxil? 

What is the best time of day to take Paxil? 

The best time of the day to take Paxil (Paroxetine) depends on the side effects this antidepressant causes. The best time to take Paxil according to the side effects is:

  • Insomnia – take it in the morning. 
  • Sleepiness/drowsiness /fatigue – take in at night. 
  • Sexual side effects – take it in the morning. 
  • Loss of appetite – take it at night. 
  • Frequent urination – take it in the morning. 

It’s best to consult your healthcare provider to determine the best possible time for you to take Paxil. Most people take Paxil in the morning and it works well for them. However, if it causes tiredness or affects your mental alertness, it’s not suitable to take this antidepressant in the morning. 

Once you know how Paxil affects you and what kinds of side effects it causes, you can take this medication accordingly. If you wish to change your current timing, talk to your doctor. Make sure you take Paxil properly. 

If you’re a new user, don’t let the minor side effects get the best of you. Most early side effects begin to disappear as your body adjusts. It does take some time, but you will eventually get there. If it causes severe side effects, talk to your healthcare provider. 

Important considerations when taking Paxil

Some important considerations when taking Paxil include: (1,2)

  • Take Paxil exactly as prescribed by your healthcare provider. Do not exceed the recommended dosage or change the dosing schedule without consulting your doctor.
  • It may take a few weeks before you start experiencing the full benefits of Paxil. Continue taking it as directed, even if you don’t notice immediate improvements.
  • If you decide to stop taking Paxil, do not abruptly discontinue the medication.
  • Make sure to inform your healthcare provider about any other medications, supplements, or herbal remedies you are taking to avoid possible interactions.

  • You can cut Paxil in half if you find it difficult to consume it whole due to an underlying swallowing difficulty. However, do not cut the tablets in half to reduce the dose without consulting your doctor first.
  • It’s advisable to limit or avoid alcohol consumption while taking Paxil. Alcohol can intensify the side effects of the medication.
  • Paxil can cause drowsiness, tiredness, or dizziness, which may impair your ability to drive or operate machinery. Paxil can also cause weight loss if combined with another antidepressant or medication that can also lead to weight loss, like Wellbutrin.
  • Your doctor may want to monitor your progress and adjust the dosage if needed. Attend follow-up appointments as scheduled to discuss your response to the medication

Was this helpful?

Thanks for your feedback!



Shrestha P, Fariba KA, Abdijadid S. Paroxetine. 2022 Jul 19. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2023 Jan–. PMID: 30252278. https://www.ncbi.nlm.nih.gov/books/NBK526022


Bourin M, Chue P, Guillon Y. Paroxetine: a review. CNS Drug Rev. 2001 Spring;7(1):25-47. doi: 10.1111/j.1527-3458.2001.tb00189.x. PMID: 11420571; PMCID: PMC6741642. https://pubmed.ncbi.nlm.nih.gov/11420571/

Find a supportive therapist who can help with Depression.

Discover the convenience of BetterHelp, an online therapy platform connecting you with licensed and accredited therapists specialized in addressing issues such as depression, anxiety, relationships, and more. Complete the assessment and find your ideal therapist within just 48 hours.


AskYourPharm is user-supported. We may earn a commission if you sign up for BetterHelp’s services after clicking through from this site