How long does it take for Pristiq to work? 

How long does it take for Pristiq to work? 

Pristiq can take 4-6 weeks to start working for depression and related symptoms. However, you may find your sleep quality, appetite, and energy levels getting better within a week or two. 

These early positive signs usually indicate that Pristiq is working and it will manage symptoms associated with your depression effectively. Antidepressants alter the level of excitatory neurotransmitters in your brain and this process can take time (1). 

Not only this, but your body takes time to adjust to this change and to actually start responding to it. Some people may begin to feel the beneficial effects of Pristiq earlier than others. 

However, people always respond differently to medications, especially those meds which can alter brain chemistry. Paxil may cause side effects in some people, like nausea, upset stomach, night sweats, nightmares, weight gain or loss, or sexual side effects.

What to do if you don’t begin to feel better on Pristiq? 

If you’re properly taking Pristiq for weeks but you don’t observe any positive change in your symptoms, reach out to your healthcare provider. Pristiq is a good antidepressant generally, but it may not work well for every other person. 

If Pristiq fails to manage your depression or causes side effects that make it extremely difficult for you to continue taking this medication, your doctor will most likely switch you to another antidepressant. 

There are plenty of antidepressants that can easily replace Pristiq. However, it’s best to give your body time to adjust to the med, if it doesn’t cause unbearable side effects. 

Mild early side effects are common with almost every other antidepressant and you shouldn’t let them discourage you. Most of these side effects begin to subside within a few weeks as your body adjusts to the medication. 

It is also important to ensure you’re taking Pristiq as properly as possible, without skipping your doses. Remember, proper use of meds is the key to achieving the best possible therapeutic outcome. 

Final words

To sum up, Pristiq can take a few weeks to work. You may experience some early side effects during the first few weeks, they soon disappear as your body adjusts to the medication. If for some reason, Pristiq fails to benefit your mental health condition, there are other meds you can try.

Determining the best antidepressant is a trial and error process and you may need to try several antidepressants to find the one that suits you and your symptoms best. Just make sure you don’t switch to any other medication on your own or stop taking Pristiq abruptly. 

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National Library of Medicine (US). Desvenlafaxine. Bethesda (MD): U.S. National Library of Medicine; 2021 Mar 15 [updated 2021 Mar 15; cited 2022 Feb 22]. Available from:

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