What cold medications are safe to take with Lexapro? 

What cold medications are safe to take with Lexapro? 

There are some cold medications that are considered safe to be taken with Lexapro. These include:

  • Anti-allergy medications (Antihistamines) 
  • Guaifenesin (Mucinex) 
  • Vitamin C or zinc supplements 
  • Acetaminophen 

Lexapro is an antidepressant belonging to the class of selective serotonin reuptake inhibitors (SSRIs). Although Lexapro is considered the safest antidepressant, it might still react with some medications. Let’s get into the details of cold meds that you can use with Lexapro. 

Anti-allergy medications (Antihistamines) 

Usual antihistamines like Cetirizine, Loratadine, etc can be used with Lexapro. These meds can control a huge range of allergy symptoms and can be used for seasonal allergies as well. 

Although the use of Lexapro with such antihistamines is pretty common, excessive use or misuse can lead to some side effects, like sedation, dry mouth, etc. Make sure you take as much as needed and don’t take any more than that. 

Guaifenesin (Mucinex)

Mucinex is also safe to be taken with Lexapro. Guaifenesin, the active ingredient, unclogs your airways by removing the thick mucus. This helps relieve chest congestion, which is a very common symptom of a cold. 

These two meds are used together quite often and there is no drug-drug interaction reported. However, I would recommend using the original Mucinex and not any of its other variants as they may contain ingredients which could interact with your Lexapro. 

Vitamin C or zinc supplements 

Vitamin C or zinc supplements can be safely taken with Lexapro. They are not medications and are found in the body normally. Vitamin C and Zinc are excellent to boost your immunity against the common cold and flu. 


Acetaminophen (Tylenol) can also be taken safely along with Lexapro. In fact, Acetaminophen is considered the only safe painkiller to be taken with antidepressants because there are known interactions between antidepressants and pain reducers. 

With Acetaminophen, there is no such interaction reported and you can safely take Tylenol 3 to 4 times a day, as per your need. 

What cold medications should not be taken with Lexapro? 

There are some cold medications that should not be taken with Lexapro. These include Pseudoephedrine and Dextromethorphan. 

These two meds can interact with Lexapro and can cause cardiovascular side effects like arrhythmia, high blood pressure, palpitations, QT elongation, etc. 

These side effects can vary in intensity, depending on your age and how much of these meds are taken. Make sure you steer clear of these cold meds while you’re on Lexapro. This antidepressant should also be avoided with non-steroidal anti-inflammatory drugs like Ibuprofen, Naproxen, etc unless recommended by a doctor. 

You can always rely on conventional methods to relieve cold and flu, like ginger-honey tea, lemon-honey tea, liquorice tea, salt-water gargling, applying vaporub, etc. These meds are often found effective and they don’t interfere with your antidepressant. 

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MedlinePlus. Escitalopram. MedlinePlus drug information [Internet]. Bethesda (MD): National Library of Medicine (US); [updated 2022 Feb 15; cited 2022 Oct 4]. Available from: https://medlineplus.gov/druginfo/meds/a603005.html

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