Is Tylenol safe to take with Lexapro?

Is Tylenol safe to take with Lexapro?

Yes, Tylenol (Acetaminophen) is absolutely safe to take with Lexapro (Escitalopram). The two medications do not interact with one another. 

Painkillers are usually considered dangerous when used with antidepressants because of how they both work once inside your body at the same time. 

In such a case, Tylenol is always preferred over other painkillers because of its good safety and tolerability profile when used concomitantly with antidepressants like Lexapro. So yes, you can safely take Tylenol 2-3 times a day with Lexapro. 

Other acetaminophen-containing formulations, like NyQuil, can also be taken while taking Lexapro. However, it’s best to space such formulations out to minimise potential interactions, as such formulations do contain other active ingredients as well.

Why is Tylenol preferred over other painkillers to use with antidepressants? 

Tylenol is preferred over other painkillers because it doesn’t pose health risks when combined with antidepressants. It does not interfere with how antidepressants work and since they don’t cause common side effects, you will most likely stay safe on these meds. 

If we look at other painkillers, all of them are heavier than Tylenol. NSAIDs for instance, should not be paired with Lexapro because they can interfere with the absorption of your antidepressant. 

When the drug is not absorbed properly, it does not reach its required bioavailability and hence, you don’t achieve the desired therapeutic response. 

Not only this, but NSAIDs can also cause severe gastrointestinal bleeding when taken along with antidepressants, especially SSRIs. Lexapro can cause some side effects like acid reflux, nausea, upset stomach, etc which may also become more pronounced when the antidepressant is taken with NSAIDs.

If we go higher than that and look at even stronger painkillers, like the ones belonging to the Opioid family, the chances of health risks increase. 

Since Opioids affect your brain, the concomitant use with antidepressants can cause a variety of side effects. This is why it’s best to opt for Acetaminophen when you’re on antidepressants. 

However, if you feel your pain is not subsiding by taking Tylenol, talk to your healthcare provider. Don’t start using a new painkiller without your doctor’s approval. 

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MedlinePlus. Escitalopram. MedlinePlus drug information [Internet]. Bethesda (MD): National Library of Medicine (US); [updated 2022 Feb 15; cited 2022 Dec 7]. Available from:


MedlinePlus. Acetaminophen. MedlinePlus drug information [Internet]. Bethesda (MD): National Library of Medicine (US); [updated 2022 Feb 15; cited 2022 Dec 7]. Available from: