Is it safe to take Ibuprofen with Lexapro? 

Is it safe to take Ibuprofen with Lexapro?

It’s generally not considered safe to take Ibuprofen with Lexapro. There is a possibility of a mild to moderate interaction between the two and there is a risk of some disturbing side effects. 

Ibuprofen is a Non-steroidal anti-inflammatory drug (NSAID) used to reduce pain, inflammation, and fever. Lexapro is an antidepressant which belongs to the class of selective serotonin reuptake inhibitors (SSRIs). 

This class of antidepressants usually don’t do that well with NSAIDs, especially if taken at the same time. 

What are the dangers associated with the use of Ibuprofen and Lexapro together? 

There are some health risks when it comes to using Ibuprofen and Lexapro together. These include (1,2):

Risk of gastrointestinal bleeding 

The concomitant use of Ibuprofen and Lexapro can increase the risk of bleeding. This is because both Ibuprofen and Lexapro can affect the platelet aggregation that is responsible for blood clotting. 

This leads to an increased risk of gastrointestinal bleeding. However, this risk is more common in people with an underlying GI disease like ulcers – as Lexapro can generally cause acid reflux and pairing it with Ibuprofen can have a more significant effect on gastrointestinal bleeding. 

Possibility of Lexapro malabsorption

A few studies have revealed that Ibuprofen may reduce the absorption of Lexapro, to some extent. Although it is not common in every case, it is an unpredictable possibility. 

Experts believe that some factors could make some people more sensitive to this effect. 

Gastrointestinal side effects 

Another possibility is gastrointestinal side effects. Lexapro, although not associated with severe GI side effects, could affect your stomach and you may experience nausea, diarrhoea, flatulence, abdominal pain, etc. Ibuprofen, on the other hand, can cause a number of GI side effects. 

In fact, the entire class of NSAIDs can put you at risk of ulcers as these meds can damage the protective mucosa lining around your stomach. Taking Lexapro and Ibuprofen together can significantly increase the intensity of such side effects. 

What would be an alternative to Ibuprofen to take with Lexapro? 

If you’re in pain, I would recommend taking Acetaminophen. It is considered the safest painkiller to use with antidepressants. You can take 2 Acetaminophen tablets at one time and can take it 3-4 times a day. 

However, if your pain is comorbid with inflammation and Acetaminophen fails to control it, you can take Ibuprofen, but you need to change the timing. Lexapro and Ibuprofen can interact more prominently if taken at the same time. 

This is why take them at separate times and don’t take too much Ibuprofen. If you’re concerned about the side effects, talk to your doctor or pharmacist. 

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MedlinePlus. Ibuprofen. MedlinePlus drug information [Internet]. Bethesda (MD): National Library of Medicine (US); [updated 2022 Feb 15; cited 2022 Nov 23]. Available from:


MedlinePlus. Escitalopram. MedlinePlus drug information [Internet]. Bethesda (MD): National Library of Medicine (US); [updated 2022 Feb 15; cited 2022 Nov 23]. Available from: