Does Zofran show up on a drug test? 

Does Zofran show up on a drug test? 

Zofran (Ondansetron) does not generally show up on a drug test. It is not a controlled substance and standard drug tests do not focus on this medication. 

Zofran is an OTC antiemetic medication and it does not cause any dependence or addiction. So it will not really show up on a standard panel drug test and it is not known to cause a false positive for any other substance of abuse. 

If you are taking Zofran and your drug test is coming up, you don’t need to worry about it. However, I still recommend not taking any medication right before your test because of the unreliability of cheap drug testing procedures – like urine immunoassay. 

They may show false positives for controlled substances. In that case, it’s better to go for more sensitive and accurate testing procedures like Gas Chromatography – Mass spectroscopy (GC-MS) for more promising results. (1)

How is Zofran different from drugs that commonly show up on a drug test?

As stated earlier, Zofran is not a drug of abuse and is not known to produce psychoactive effects or cause dependence. It works by blocking certain receptors in the body that trigger nausea and vomiting. (2)

It is often prescribed to individuals undergoing chemotherapy, radiation therapy, or surgery, as these treatments can induce severe nausea. It can also be used to prevent nausea and vomiting associated with other medical conditions or medications. (3)

Drug tests are usually designed to detect specific substances commonly abused or controlled substances, which have a high potential for addiction and abuse (4). These medications should never be used without a prescription. 

Final words

To sum up, Zofran does not show up on a drug test and it doesn’t affect your body the way controlled substances do. However, it’s important to note that while Zofran is generally considered safe and well-tolerated, it may still have its own side effects and interactions with other medications. 

It is always recommended to consult with a healthcare professional before taking any medication to ensure its appropriateness for your specific situation and to understand any potential risks or interactions – as Zofran may interact with alcohol, antidepressants, and several other medications.

So, make sure you stick to the recommended doses and frequency. Always check for drug expiry before you take any medication, including Zofran. An expired Zofran tablet may not cause you any harm, but it might not work to help your symptoms either.

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Ramoo B, Funke M, Frazee C, Garg U. Comprehensive Urine Drug Screen by Gas Chromatography/Mass Spectrometry (GC/MS). Methods Mol Biol. 2016;1383:125-31. doi: 10.1007/978-1-4939-3252-8_15. PMID: 26660182. Available from:


Griddine A, Bush JS. Ondansetron. 2023 Feb 15. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2023 Jan–. PMID: 29763014.


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McNeil SE, Chen RJ, Cogburn M. Drug Testing. 2023 Jan 16. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2023 Jan–. PMID: 29083751.