Does Wellbutrin cause skin rash? 

Does Wellbutrin cause skin rash? 

No, Wellbutrin does not generally cause a skin rash or any other skin-related side effects. If you begin to notice a rash on your skin right after taking Wellbutrin, immediately reach out to your healthcare provider. 

A small number of people are allergic to Wellbutrin, and skin rash could be the first sign of an allergic reaction to this antidepressant. This is why you should immediately seek medical attention if you develop a rash or other symptoms of an allergic reaction – some of which include:

  • Painful blisters on the skin, urticaria or hives, burning sensation, blue-purple patches, etc. (1)
  • Tightness of chest, difficulty in breathing, hoarseness, etc. 
  • Swelling of tongue, lips, face, eyes, or throat.

Can skin rash just be a side effect of Wellbutrin and not an allergic reaction? 

Although skin rash is not reported as a common side effect of Wellbutrin, it could be a possibility in a small number of people. Wellbutrin may also cause photosensitivity in rare cases.

If you have been taking Wellbutrin for quite a while now, and you suddenly start to notice a rash on your skin, it could be related to other things and not the antidepressant. 

You should look out for any recent lifestyle change that you’ve had, or any food you have tried recently that you could be allergic to. Some people may develop side effects during the course of their antidepressant treatment, especially when their doses are escalated. (2)

If your Wellbutrin dose has recently increased and you notice a rash, it doesn’t indicate an allergy to the medication. It’s best to discuss your side effects with your healthcare provider and rule out other factors that may be silently causing a skin rash. 

It’s not recommended to stop Wellbutrin or any other antidepressant abruptly. Just head out to your healthcare provider and discuss the future safety and efficacy of Wellbutrin use. 

What to do if you are allergic to Wellbutrin? 

If you are allergic to Wellbutrin or any medication, it is important to seek medical attention right away. Allergic reactions can vary in severity, and it’s crucial to address them promptly. 

If you experience symptoms such as difficulty breathing, swelling of the face, lips, tongue, or throat, or a severe skin rash, it may indicate an allergic reaction. 

In such cases, you should immediately stop taking Wellbutrin and contact your healthcare provider or go to the nearest emergency room. They will evaluate your symptoms and provide appropriate treatment, which may include medication to manage the allergic reaction. 

It’s important to inform your healthcare provider about your allergy to Wellbutrin or any other medications to ensure your safety and determine suitable alternative treatments if necessary.

Alternatives to Wellbutrin if you are allergic to it

If Wellbutrin is not suitable for you due to allergies, there are alternative medications that your healthcare provider may consider. 

It’s important to discuss your specific needs and concerns with your doctor to determine the most appropriate alternative. Some possible alternatives to Wellbutrin include:

  • Selective serotonin reuptake inhibitors (SSRIs): These are a commonly prescribed class of antidepressant medications, such as Prozac (fluoxetine), Zoloft (sertraline), and Lexapro (escitalopram). They work by increasing the levels of serotonin in the brain to improve mood. (3)
  • Serotonin-norepinephrine reuptake inhibitors (SNRIs): Medications like Cymbalta (duloxetine) and Effexor (venlafaxine) are SNRIs that help regulate the levels of serotonin and norepinephrine in the brain, which can help alleviate symptoms of depression. (4)
  • Tricyclic antidepressants (TCAs): TCAs, such as Elavil (amitriptyline) and Pamelor (nortriptyline), are older antidepressants that can be effective for certain individuals. They work by balancing the levels of neurotransmitters in the brain. (5)
  • Atypical antidepressants: There are several other antidepressant medications that don’t fit into the traditional categories mentioned above. Examples include Remeron (mirtazapine) and Wellbutrin (bupropion) XL or SR, which is an extended-release form of bupropion. (6)

Remember, each medication has its own benefits and potential side effects. Your healthcare provider will consider various factors, such as your medical history, current symptoms, and any other medications you may be taking, to determine the most suitable alternative to Wellbutrin for your specific situation.

Was this helpful?

Thanks for your feedback!



Gutierrez N, Malik S, Cohen PR, Winn AE. Bupropion-Associated Delayed Onset Urticaria. Cureus. 2021 Sep 26;13(9):e18297. doi: 10.7759/cureus.18297. PMID: 34722072; PMCID: PMC8547370.


Huecker MR, Smiley A, Saadabadi A. Bupropion. 2023 Apr 9. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2023 Jan–. PMID: 29262173.


Chu A, Wadhwa R. Selective Serotonin Reuptake Inhibitors. 2023 May 1. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2023 Jan–. PMID: 32119293.


Sansone RA, Sansone LA. Serotonin-norepinephrine reuptake inhibitors: a pharmacological comparison. Innov Clin Neurosci. 2014 Mar;11(3-4):37-42. PMID: 24800132; PMCID: PMC4008300.


Moraczewski J, Aedma KK. Tricyclic Antidepressants. 2022 Nov 21. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2023 Jan–. PMID: 32491723.


Maj J. Atypical antidepressant drugs – psychopharmacological profile and mechanism of action. Pharmacopsychiatria. 1982 Jan;15(1):26-30. doi: 10.1055/s-2007-1019505. PMID: 7199735.

Find a supportive therapist who can help with Depression.

Discover the convenience of BetterHelp, an online therapy platform connecting you with licensed and accredited therapists specialized in addressing issues such as depression, anxiety, relationships, and more. Complete the assessment and find your ideal therapist within just 48 hours.


AskYourPharm is user-supported. We may earn a commission if you sign up for BetterHelp’s services after clicking through from this site