Does Wellbutrin cause photosensitivity? (3+ strategies)
By
Ivan Kahwa
Author bio
Mr Ivan Kahwa is a chemist and phytopharmaceutical scientist with expertise in chemistry, pharmacology, phytochemistry, and Nanobiotechnology. He writes and reviews content on these topics.
Mr Ivan Kahwa’s Highlights:
Guest Researcher at the University of Leipzig, Senior Research Fellow/Scientist, and Lecturer at the Department of Pharmacy, Faculty of Medicine, Mbarara University of Science and Technology.
Professional Experience:
Mr Ivan joined PHARMBIOTRAC as a research fellow/scientist during his master of science tenure. He contributed to the development of most of the phytopharmaceutical products in the project. Furthermore, he participated in carrying out the pharmacological activities of the developed products in laboratory animals such as mice and rats in order to develop proper doses hence leading to pre-clinical studies.
With the above relevant research experience, Ivan started to work with the University of Leipzig on collaborative projects with Mbarara University to develop the chemistry of Ugandan Medicinal plants and their pharmacological activities. This was coupled with several consultative positions by different German NGOs. Mr. Kahwa is also a supporting in the teaching and learning at the Departments of Pharmacy and Pharmaceutical Sciences, Faculty of Medicine, Mbarara University of Science and Technology.
With the increase in antimicrobial resistance globally, Ivan retooled his thinking towards developing new naturally derived antibiotic regimens from Ugandan propolis with the assistance of nanotechnology to improve their delivery to microbial cells. Kahwa has also published over 28 articles in peer-reviewed journals and he is currently reviewing for many journals.
Education:
2023-2027: PhD in Pharmaceutical Sciences (ongoing) with a focus on Pharmaceutical Microbiology and Nanobiology at Mbarara University of Science and Technology.
2022: 2Msc. in Pharmacognosy and Natural Medicine Science at Mbarara University of Science and Technology.
2018: Bachelor of Science (Chemistry) at Mbarara University of Science and Technology.
Publications:
▪ Iqbal, S., Jabeen, F., Kahwa, I., & Omara, T. 2023. Suberosin Alleviates Thiazolidinedione-Induced Cardiomyopathy in Diabetic Rats by Inhibiting Ferroptosis via Modulation of ACSL4-LPCAT3 and PI3K-AKT Signaling Pathways. Cardiovascular Toxicology. https://doi.org/10.1007/s12012-023-09804-7
▪ Gupta, A. K., Yadav, R., Sharma, S., Sawale, J., & Kahwa, I. 2023. Anti-ageing Activity and Antioxidant Activity of Methanol Extracts of Leaves and Flowers of Salvia officinalis and Rosmarinus officinalis. Journal of Young Pharmacists, 15(3), 448–455. https://doi.org/10.5530/jyp.2023.15.60
▪ Tolo, C.U., Kahwa, I., Nuwagira, U., Weisheit, A. and Ikiriza, H., 2023. Medicinal plants used in treatment of various diseases in the Rwenzori Region, Western Uganda. Ethnobotany Research and Applications, 25, pp.1-16.
https://ethnobotanyjournal.org/index.php/era/article/view/4683
▪ Kahwa, I., Ajayi, C.O., Yadav, R., Chauhan, N.S., Shah, K., Abdelgadir, A.A., Shegena, E.A., Daniel, S., Omara, T., Asiimwe, J.B. and Ikiriza, H., 2023. Pharmacognostic and phytochemical studies as an invaluable approach for correct identification of medicinal plants: The case of Artemisia vulgaris L. substituted for Artemisia annua L. in Western Uganda. TMR Integr Med, 7, p.e23004.
https://doi.org/10.53388/TMRIM202307004
▪ Nalimu, F., Oloro, J., Kahwa, I. and Ogwang, P.E., 2021. Review on the phytochemistry and toxicological profiles of Aloe vera and Aloe ferox. Future Journal of Pharmaceutical Sciences, 7, pp.1-21.
https://doi.org/10.1186/s43094-021-00296-2
▪ Elamin, O.H.S., Ali, M.A., Elgezuli, I.A.A., Bashir, M.A. and Kahwa, I., 2021. Diagnosis of pre-and post-treatment of echinococcus granulosus with counter current immune electrophoresis and bacterial co-agglutination. Journal of Microbiology and Infectious Diseases, 11(02), pp.88-94.
https://doi.org/10.5799/jmid.951600
Published book Chapter
▪ Kahwa, I., Ayesiga, I., Nakalema, S., Alinaiswe, R., Mbabazi, R. and Iqbal, S., 2023. Natural products in the management of onchocerciasis. In Natural Products in Vector-Borne Disease Management (pp. 63-80). Academic Press. Book Chapter.
https://doi.org/10.1016/B978-0-323-91942-5.00012-4
Submitted manuscripts Under Review:
▪ Comparison of the Wound Healing Activity of the Leaf and Leaf Ash Extracts of Vernonia amygdalina in Rats. Journal name: Clinical Phytoscience
▪ Ethnobotanical Survey of Medicinal plants used in the management of cancer in Uganda. Journal name: Journal of Herbal Medicine
▪ Ethnobotanical survey and phytochemical screening of medicinal plants used in treatment of epilepsy by PROMETRA-Uganda Traditional Health Practitioners in Mpigi District, Uganda. Journal name: Journal of Ethnopharmacology
Submitted book chapters under review
1.Book title: Algae as a Natural Solution for Water-Food-Energy Nexus, Section 4: Microalgae and cyanobacteria for food applications, Chapter 4.6: Safety, toxicological and allergenic aspects of using algae for food. Authors: Christine Kyarimpa, Tom Omute, Caroline K. Nakiguli, Alice V. Khanakwa4, Christopher Angiro, Ivan Kahwa, Fortunate Ahumuza, Timothy Omara*. Publisher: Springer Nature Singapore Pte Ltd. 152 Beach Road, #21-01/04 Gateway East, Singapore 189721, Singapore.
2.Book title: Nutraceuticals Inspiring the Contemporary Therapy for Lifestyle Diseases. Chapter: Nutraceutical applications of Seaweeds and their Phytocompounds in Nutrition and Treatment of Diseases. Authors: Ivan Kahwa, Timothy Omara , Innocent Ayesiga , Gael Noel Neh Neba Ambe , Zehbanaz Javidbhai Panwala , Rachel Mbabazi , Shabnoor Iqbal , Christine Kyarimpa , Christine Betty Nagawa , Kamal Shah ,Nagendra Singh Chauhan* Publisher: CRC Press
You can view my works on the following professional sites:
Research Gate: https://www.researchgate.net/profile/Ivan-Kahwa
Google Scholar: https://scholar.google.com/citations?user=tOwrvqoAAAAJ&hl=en
ORCID: https://orcid.org/0000-0002-6440-3437
Linkedin: https://de.linkedin.com/in/ivan-kahwa-865450159
In this article, we will discuss light sensitivity induced by Wellbutrin. We will also explore the mechanisms of photosensitivity associated with Wellbutrin and how to manage this side effect.
Does Wellbutrin cause photosensitivity?
Wellbutrin ( Bupropion) can cause photosensitivity. However, this is not a common side effect and the incidence is low.
Wellbutrin, a brand for Bupropion, is an antidepressant medication used to treat depression and help with smoking cessation. It works by affecting neurotransmitters in the brain, primarily norepinephrine and dopamine (1).
Wellbutrin is associated with several common and rare side effects including dry mouth, tremors, heartburn, dizziness and tiredness. These side effects are mostly common in individuals who are new to this medication or antidepressants in general.
Photosensitivity, also known as photosensitivity, is not commonly seen in individuals taking Wellbutrin. However, some may rarely develop this side effect during the early course of their treatment with Wellbutrin.
The early side effects of the medication usually subside on their own as your body gets used to the medication.
What does research suggest?
There are a limited number of cases that report Wellbutrin-induced photosensitivity reactions. However, antidepressants in general can cause photosensitivity, which is relatively more common in people who are new to Wellbutrin or antidepressants in general.
Drug-induced photosensitivity refers to the development of skin disease due to chemical agents or sunlight exposure.
One research study includes a 44-year-old woman who had been prescribed Wellbutrin to manage depression. The woman developed a rash on her skin after starting the antidepressant. The rash was red, itchy and sensitive to light. The woman was diagnosed with subacute cutaneous lupus erythematosus (SCLE) (2).
Her doctors told her to stop taking Bupropion, use sunscreen and apply a medication called Tacrolimus. The rash disappeared within a month (2).
Based on laboratory findings, it was suggested that SCLE was associated with using Bupropion. Therefore, this antidepressant was discontinued and the symptoms improved (2).
This case suggested that some medications, like Bupropion, can trigger a specific type of lupus skin condition, and doctors need to know about a patient’s medications when they suspect this condition.
Mechanism of Wellbutrin-induced photosensitivity
The exact mechanism of Wellbutrin-induced photosensitivity is not well understood, and it is considered a rare side effect. Photosensitivity reactions can be complex and are not limited to a single mechanism.
However, Wellbutrin is thought to alter the way the skin responds to sunlight, possibly by affecting the skin’s sensitivity to ultraviolet (UV) radiation. This altered sensitivity to UV radiation can lead to skin reactions when exposed to sunlight, such as rashes or other skin issues (2).
It is essential to consult a healthcare professional if you suspect you are experiencing photosensitivity or any unusual side effects while taking Bupropion. They can provide guidance and recommend appropriate management.
Symptoms of Wellbutrin-induced photosensitivity
Erythema is one of the most common symptoms of drug-induced photosensitivity. However, other symptoms of Wellbutrin-induced photosensitivity include the following (3):
- Pigmentation
- Pustules
- Eczema
- Itching
During the physical examination of patients with photosensitivity, it is observed that body areas that are most exposed to the sun, such as the face, hands, neck and forearm show more damage. While the areas least exposed or not exposed to the sun like breasts and genitalia remain unaffected (3).
How to manage wellbutrin-induced photosensitivity?
If you experience photosensitivity while using Wellbutrin, your healthcare provider will take the following measures to manage it.
Medication adjustment: Depending on the severity of photosensitivity and the patient’s medical condition, the healthcare provider may consider discontinuing Wellbutrin or adjusting the dosage. In some cases switching to an alternative antidepressant with a lower risk of photosensitivity may be recommended.
Sun protection: To reduce the risk of sun reactions, your healthcare provider may recommend using sunscreen and wearing protective clothing.
Topical treatments: In some cases, topical treatments, such as corticosteroid creams or non-steroidal anti-inflammatory drugs, may be recommended to manage skin problems like rashes or irritation.
Stay hydrated: Proper hydration can help maintain healthy skin. Drink enough water to stay hydrated.
Always remember, do not discontinue antidepressants on your own as it can cause discontinuation syndrome characterized by symptoms such as hallucinations, agitation, dizziness, high blood pressure etc (4).
Conclusion
In conclusion, photosensitivity is not a common or well-documented side effect of Wellbutrin. While individual responses to medications can vary, and some people may experience unusual side effects.
If you experience photosensitivity while taking Wellbutrin, it is essential to consult a healthcare provider to determine the cause of the symptoms and explore appropriate management and treatment options.
Was this helpful?
References
2.-
Cassis TB, Callen JP. Bupropion-induced subacute cutaneous lupus erythematosus. Australas J Dermatol. 2005 Nov;46(4):266-9. doi: 10.1111/j.1440-0960.2005.00199.x. PMID: 16197429.https://pubmed.ncbi.nlm.nih.gov/16197429/
3.-
Kowalska J, Rok J, Rzepka Z, Wrześniok D. Drug-Induced Photosensitivity-From Light and Chemistry to Biological Reactions and Clinical Symptoms. Pharmaceuticals (Basel). 2021 Jul 26;14(8):723. doi: 10.3390/ph14080723. PMID: 34451820; PMCID: PMC8401619.https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8401619/#:~:text=These%20effects%20contribute%20to%20the,basis%20of%20drug%2Dinduced%20photosensitivity.
4.-
Gabriel M, Sharma V. Antidepressant discontinuation syndrome. CMAJ. 2017 May 29;189(21):E747. doi: 10.1503/cmaj.160991. PMID: 28554948; PMCID: PMC5449237.https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5449237/#:~:text=The%20mnemonic%20FINISH%20summarizes%20the,disturbances%20(%E2%80%9Cburning%2C%E2%80%9D%20%E2%80%9C
Find a supportive therapist who can help with Depression.
Discover the convenience of BetterHelp, an online therapy platform connecting you with licensed and accredited therapists specialized in addressing issues such as depression, anxiety, relationships, and more. Complete the assessment and find your ideal therapist within just 48 hours.
AskYourPharm is user-supported. We may earn a commission if you sign up for BetterHelp’s services after clicking through from this site
