Does Wellbutrin cause itching all over your body? 

Does Wellbutrin cause itching all over your body?

No, Wellbutrin does not generally cause itching all over your body. Skin-related side effects are extremely rare with Wellbutrin. However, if you start feeling itchy all over after taking Wellbutrin, it’s best to reach out to your healthcare provider.

According to the prescribing information for Wellbutrin, itching is reported in less than 1% of patients who take the medication. However, it is important to note that the actual incidence of itching may be higher, as some cases may go unreported or unrecognized. 

Could itching be a sign of an allergic reaction?

A small number of people are allergic to this antidepressant, and itching all over your body could be the first sign of such an allergic reaction. This is why you should seek immediate medical attention if you are struggling with itching after your very first Wellbutrin dose. 

An allergic reaction to Wellbutrin is commonly associated with the following signs and symptoms:

  • Skin rash, hives, itching, burning sensation, blue-purple patches, painful blisters, etc. 
  • Tightness of chest, difficulty in breathing, hoarseness, etc. 
  • Swelling of tongue, lips, face, eyes, or throat. 
  • Rapid or irregular heartbeat
  • Fever or chills
  • Nausea, vomiting, or diarrhoea

Wellbutrin may cause delayed onset urticaria

According to researchers, there are some cases in which patients have experienced itching and rash after weeks of using Wellbutrin (1). The experts indicate that some people may be allergic to Wellbutrin but the antidepressant may not trigger an allergic reaction right away.

Such people may develop hypersensitivity symptoms after 2-3 weeks of starting the antidepressant. This type of urticaria can be easily managed with safe drug discontinuation and antihistamines.

What to do if Wellbutrin causes itching all over your body? 

You should reach out to your healthcare provider if Wellbutrin causes itching all over your body. As I discussed in the previous section, Wellbutrin does not commonly cause skin-related side effects, and itching right after taking Wellbutrin could be a sign of an allergic reaction. 

In such cases, symptomatic treatment helps overcome your allergy and the use of Wellbutrin is discontinued. There are plenty of other antidepressants which are just as good as Wellbutrin, and your doctor will most likely switch you to such an antidepressant once you recover from the allergy symptoms. 

Your healthcare provider may recommend an antihistamine to control the itch, which usually goes away within a few days.

Final words

It is best to talk to your doctor if Wellbutrin causes itching all over your body. This is not a commonly expected side effect and an allergic reaction should be ruled out right away. If you experience itching after using Wellbutrin for a while, there could be something else responsible for it.

Your doctor can help you determine the exact cause and the best treatment strategy to help you with itching.

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Gutierrez N, Malik S, Cohen PR, Winn AE. Bupropion-Associated Delayed Onset Urticaria. Cureus. 2021 Sep 26;13(9):e18297. doi: 10.7759/cureus.18297. PMID: 34722072; PMCID: PMC8547370. Available from:

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