Does Wellbutrin cause breast enlargement? (3+ reasons)

In this article, we aim to address the question: “Does Wellbutrin cause breast enlargement?” We will also discuss potential reasons for breast enlargement while taking Wellbutrin.

Does Wellbutrin cause breast enlargement?

Wellbutrin (Bupropion) is not typically known to cause breast enlargement as a side effect. Research shows that there is no direct link between Wellbutrin (Bupropion) and breast enlargement or tenderness. (1)

It is natural to be concerned about breast enlargement while taking antidepressants, as certain antidepressants, particularly Selective Serotonin Reuptake Inhibitors (SSRIs), have been linked to breast enlargement and swelling. Fortunately, Wellbutrin does not have such side effects. (2)

Breast enlargement is commonly caused by hormonal changes throughout a woman’s life. Female hormones are not significantly affected by Wellbutrin. Instead, by increasing norepinephrine and dopamine levels, it improves mood and alleviates depression. (1)

What are other causes of breast enlargement while taking Wellbutrin?

Breast enlargement while using Wellbutrin (Bupropion) is not a commonly reported side effect, but various factors can contribute to changes in breast size while taking Wellbutrin.

Weight gain

One of the primary factors to consider when discussing breast enlargement with Wellbutrin is weight gain. While it is not prevalent, some individuals may experience an increase in body weight while using Wellbutrin.

Weight gain while using Wellbutrin can also be linked with bloating and fluid retention. Weight changes are also commonly observed in people dealing with depression. (3)

Weight gain can lead to an accumulation of fat in the breast area, resulting in breast enlargement. Maintaining a healthy lifestyle and dietary choices is essential to manage body weight effectively. 

Changes with puberty and age

Breast size changes naturally with age, which is especially important when considering Wellbutrin use in the context of Premenstrual Dysphoric Disorder (PMD) or depression in young people going through puberty. (4)

Age-related growth is common and is usually caused by hormonal fluctuations and changes in body composition. It is critical to understand that this is a natural ageing process that can occur independently of medication use. (5)

Concomitant use of other medications

Interactions with other medications taken alongside Wellbutrin can also play a role in breast enlargement. 

For instance, when Wellbutrin is combined with Selective Serotonin Reuptake Inhibitors (SSRIs), such as sertraline, it has been associated with breast soreness, swelling, or other changes in breast size. (2)

It’s important to discuss any concomitant medications or substances with your doctor or pharmacist to identify potential side effects or interactions contributing to breast size changes.

Changes during pregnancy and lactation

When considering individuals who are pregnant or lactating and are prescribed Wellbutrin, it’s important to understand that any alterations in breast size are more likely a natural occurrence rather than a side effect of the medication. (6)

The female body undergoes significant changes in breast tissue during pregnancy and lactation to prepare for breastfeeding. When assessing breast size changes in these circumstances, it’s vital to consider the role of these natural processes alongside any potential medication effects.

What to do if you face breast enlargement while taking Wellbutrin?

If you notice changes in your breast size following Wellbutrin use, contact your doctor. They can evaluate whether it’s a side effect of Wellbutrin or due to other factors. They will also review your medications for potential drug interactions. 

Moreover, if you are pregnant, lactating, or planning to do so, please discuss this with your doctor. Your doctor is there to provide guidance and address your concerns.

While Wellbutrin is not widely associated with breast enlargement, it’s essential to recognise that personal reactions may vary. Every patient’s response to medication can be unique. While the majority may not experience any changes in breast size, others may notice subtle variations.

If you observe any unusual side effects, it’s advisable to consult your healthcare provider for personalised guidance and evaluation.


In summary, while Wellbutrin is not a common cause of breast enlargement, several potential causes should be considered, including weight gain, age-related growth, medication interactions, pregnancy and lactation, individual variability, and lifestyle factors. 

Consulting with a healthcare provider is vital to distinguish these factors and provide personalised guidance for managing any concerns related to changes in breast size while using Wellbutrin.

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