Does Wellbutrin Cause Breast Enlargement? (3+ Reasons)

By Ivan Kahwa

Page last updated: 07/02/2024 | Next review date: 07/02/2026

Author bio

Mr Ivan Kahwa is a chemist and phytopharmaceutical scientist with expertise in chemistry, pharmacology, phytochemistry, and Nanobiotechnology. He writes and reviews content on these topics.

Mr Ivan Kahwa’s Highlights:

Guest Researcher at the University of Leipzig, Senior Research Fellow/Scientist, and Lecturer at the Department of Pharmacy, Faculty of Medicine, Mbarara University of Science and Technology.

Professional Experience:

Mr Ivan joined PHARMBIOTRAC as a research fellow/scientist during his master of science tenure. He contributed to the development of most of the phytopharmaceutical products in the project. Furthermore, he participated in carrying out the pharmacological activities of the developed products in laboratory animals such as mice and rats in order to develop proper doses hence leading to pre-clinical studies.

With the above relevant research experience, Ivan started to work with the University of Leipzig on collaborative projects with Mbarara University to develop the chemistry of Ugandan Medicinal plants and their pharmacological activities. This was coupled with several consultative positions by different German NGOs. Mr. Kahwa is also a supporting in the teaching and learning at the Departments of Pharmacy and Pharmaceutical Sciences, Faculty of Medicine, Mbarara University of Science and Technology.

With the increase in antimicrobial resistance globally, Ivan retooled his thinking towards developing new naturally derived antibiotic regimens from Ugandan propolis with the assistance of nanotechnology to improve their delivery to microbial cells. Kahwa has also published over 28 articles in peer-reviewed journals and he is currently reviewing for many journals.

Education:

2023-2027: PhD in Pharmaceutical Sciences (ongoing) with a focus on Pharmaceutical Microbiology and Nanobiology at Mbarara University of Science and Technology.

2022: 2Msc. in Pharmacognosy and Natural Medicine Science at Mbarara University of Science and Technology.

2018: Bachelor of Science (Chemistry) at Mbarara University of Science and Technology.

Publications:

▪ Iqbal, S., Jabeen, F., Kahwa, I., & Omara, T. 2023. Suberosin Alleviates Thiazolidinedione-Induced Cardiomyopathy in Diabetic Rats by Inhibiting Ferroptosis via Modulation of ACSL4-LPCAT3 and PI3K-AKT Signaling Pathways. Cardiovascular Toxicology. https://doi.org/10.1007/s12012-023-09804-7

▪ Gupta, A. K., Yadav, R., Sharma, S., Sawale, J., & Kahwa, I. 2023. Anti-ageing Activity and Antioxidant Activity of Methanol Extracts of Leaves and Flowers of Salvia officinalis and Rosmarinus officinalis. Journal of Young Pharmacists, 15(3), 448–455. https://doi.org/10.5530/jyp.2023.15.60

▪ Tolo, C.U., Kahwa, I., Nuwagira, U., Weisheit, A. and Ikiriza, H., 2023. Medicinal plants used in treatment of various diseases in the Rwenzori Region, Western Uganda. Ethnobotany Research and Applications, 25, pp.1-16.

https://ethnobotanyjournal.org/index.php/era/article/view/4683

▪ Kahwa, I., Ajayi, C.O., Yadav, R., Chauhan, N.S., Shah, K., Abdelgadir, A.A., Shegena, E.A., Daniel, S., Omara, T., Asiimwe, J.B. and Ikiriza, H., 2023. Pharmacognostic and phytochemical studies as an invaluable approach for correct identification of medicinal plants: The case of Artemisia vulgaris L. substituted for Artemisia annua L. in Western Uganda. TMR Integr Med, 7, p.e23004.

https://doi.org/10.53388/TMRIM202307004

▪ Nalimu, F., Oloro, J., Kahwa, I. and Ogwang, P.E., 2021. Review on the phytochemistry and toxicological profiles of Aloe vera and Aloe ferox. Future Journal of Pharmaceutical Sciences, 7, pp.1-21.

https://doi.org/10.1186/s43094-021-00296-2

▪ Elamin, O.H.S., Ali, M.A., Elgezuli, I.A.A., Bashir, M.A. and Kahwa, I., 2021. Diagnosis of pre-and post-treatment of echinococcus granulosus with counter current immune electrophoresis and bacterial co-agglutination. Journal of Microbiology and Infectious Diseases, 11(02), pp.88-94.

https://doi.org/10.5799/jmid.951600

Published book Chapter

▪ Kahwa, I., Ayesiga, I., Nakalema, S., Alinaiswe, R., Mbabazi, R. and Iqbal, S., 2023. Natural products in the management of onchocerciasis. In Natural Products in Vector-Borne Disease Management (pp. 63-80). Academic Press. Book Chapter.

https://doi.org/10.1016/B978-0-323-91942-5.00012-4

Submitted manuscripts Under Review:

▪ Comparison of the Wound Healing Activity of the Leaf and Leaf Ash Extracts of Vernonia amygdalina in Rats. Journal name: Clinical Phytoscience

▪ Ethnobotanical Survey of Medicinal plants used in the management of cancer in Uganda. Journal name: Journal of Herbal Medicine

▪ Ethnobotanical survey and phytochemical screening of medicinal plants used in treatment of epilepsy by PROMETRA-Uganda Traditional Health Practitioners in Mpigi District, Uganda. Journal name: Journal of Ethnopharmacology

Submitted book chapters under review

1.Book title: Algae as a Natural Solution for Water-Food-Energy Nexus, Section 4: Microalgae and cyanobacteria for food applications, Chapter 4.6: Safety, toxicological and allergenic aspects of using algae for food. Authors: Christine Kyarimpa, Tom Omute, Caroline K. Nakiguli, Alice V. Khanakwa4, Christopher Angiro, Ivan Kahwa, Fortunate Ahumuza, Timothy Omara*. Publisher: Springer Nature Singapore Pte Ltd. 152 Beach Road, #21-01/04 Gateway East, Singapore 189721, Singapore.

2.Book title: Nutraceuticals Inspiring the Contemporary Therapy for Lifestyle Diseases. Chapter: Nutraceutical applications of Seaweeds and their Phytocompounds in Nutrition and Treatment of Diseases. Authors: Ivan Kahwa, Timothy Omara , Innocent Ayesiga , Gael Noel Neh Neba Ambe , Zehbanaz Javidbhai Panwala , Rachel Mbabazi , Shabnoor Iqbal , Christine Kyarimpa , Christine Betty Nagawa , Kamal Shah ,Nagendra Singh Chauhan* Publisher: CRC Press

You can view my works on the following professional sites:

Research Gate: https://www.researchgate.net/profile/Ivan-Kahwa

Google Scholar: https://scholar.google.com/citations?user=tOwrvqoAAAAJ&hl=en

ORCID: https://orcid.org/0000-0002-6440-3437

Linkedin: https://de.linkedin.com/in/ivan-kahwa-865450159

Ivan Kahwa

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In this article, we aim to address the question: “Does Wellbutrin cause breast enlargement?” We will also discuss potential reasons for breast enlargement while taking Wellbutrin.

Does Wellbutrin cause breast enlargement?

Wellbutrin (Bupropion) is not typically known to cause breast enlargement as a side effect. Research shows that there is no direct link between Wellbutrin (Bupropion) and breast enlargement or tenderness. (1)

It is natural to be concerned about breast enlargement while taking antidepressants, as certain antidepressants, particularly Selective Serotonin Reuptake Inhibitors (SSRIs), have been linked to breast enlargement and swelling. Fortunately, Wellbutrin does not have such side effects. (2)

Breast enlargement is commonly caused by hormonal changes throughout a woman’s life. Female hormones are not significantly affected by Wellbutrin. Instead, by increasing norepinephrine and dopamine levels, it improves mood and alleviates depression. (1)

What are other causes of breast enlargement while taking Wellbutrin?

Breast enlargement while using Wellbutrin (Bupropion) is not a commonly reported side effect, but various factors can contribute to changes in breast size while taking Wellbutrin.

Weight gain

One of the primary factors to consider when discussing breast enlargement with Wellbutrin is weight gain. While it is not prevalent, some individuals may experience an increase in body weight while using Wellbutrin.

Weight gain while using Wellbutrin can also be linked with bloating and fluid retention. Weight changes are also commonly observed in people dealing with depression. (3)

Weight gain can lead to an accumulation of fat in the breast area, resulting in breast enlargement. Maintaining a healthy lifestyle and dietary choices is essential to manage body weight effectively.

Changes with puberty and age

Breast size changes naturally with age, which is especially important when considering Wellbutrin use in the context of Premenstrual Dysphoric Disorder (PMD) or depression in young people going through puberty. (4)

Age-related growth is common and is usually caused by hormonal fluctuations and changes in body composition. It is critical to understand that this is a natural ageing process that can occur independently of medication use. (5)

Concomitant use of other medications

Interactions with other medications taken alongside Wellbutrin can also play a role in breast enlargement.

For instance, when Wellbutrin is combined with Selective Serotonin Reuptake Inhibitors (SSRIs), such as sertraline, it has been associated with breast soreness, swelling, or other changes in breast size. (2)

It’s important to discuss any concomitant medications or substances with your doctor or pharmacist to identify potential side effects or interactions contributing to breast size changes.

Changes during pregnancy and lactation

When considering individuals who are pregnant or lactating and are prescribed Wellbutrin, it’s important to understand that any alterations in breast size are more likely a natural occurrence rather than a side effect of the medication. (6)

The female body undergoes significant changes in breast tissue during pregnancy and lactation to prepare for breastfeeding. When assessing breast size changes in these circumstances, it’s vital to consider the role of these natural processes alongside any potential medication effects.

What to do if you face breast enlargement while taking Wellbutrin?

If you notice changes in your breast size following Wellbutrin use, contact your doctor. They can evaluate whether it’s a side effect of Wellbutrin or due to other factors. They will also review your medications for potential drug interactions.

Moreover, if you are pregnant, lactating, or planning to do so, please discuss this with your doctor. Your doctor is there to provide guidance and address your concerns.

While Wellbutrin is not widely associated with breast enlargement, it’s essential to recognise that personal reactions may vary. Every patient’s response to medication can be unique. While the majority may not experience any changes in breast size, others may notice subtle variations.

If you observe any unusual side effects, it’s advisable to consult your healthcare provider for personalised guidance and evaluation.

Conclusion

In summary, while Wellbutrin is not a common cause of breast enlargement, several potential causes should be considered, including weight gain, age-related growth, medication interactions, pregnancy and lactation, individual variability, and lifestyle factors.

Consulting with a healthcare provider is vital to distinguish these factors and provide personalised guidance for managing any concerns related to changes in breast size while using Wellbutrin.