Does Wellbutrin cause anger? 

In this brief article, we will answer the question “Does Wellbutrin cause anger? and other topics relevant to the subject.

Does Wellbutrin cause anger? 

Yes, Wellbutrin can cause anger, anxiety, and irritability. These side effects are common in people who are new to Wellbutrin or antidepressants in general (1,2). You may become short on temper and get angry over minor inconveniences. 

This usually happens because Wellbutrin produces dose-related central nervous system (CNS) stimulant effects in your brain, which may initially feel too much and irritate you (1,2). 

What are other possible side effects of Wellbutrin besides anger?

Some other common side effects encountered in patients treated with WELLBUTRIN are (2):

  • agitation
  • dry mouth 
  • insomnia 
  • headache/migraine 
  • nausea/vomiting 
  • constipation
  • tremors

. However, note that these side effects are typically transient and tend to diminish as your body adapts to the medication. In fact, Wellbutrin can actually contribute to improved anger management once it starts working (1,2).

What does research suggest?

Research suggests that bupropion appears to have a number of uses in a variety of conditions, in addition to its FDA indications (3).

There is one study reporting unexpected aggressive behavior due to the interaction of bupropion and alcohol (1). 

On the other hand, bupropion has shown promise as a beneficial treatment choice for adults with attention-deficit/hyperactivity disorder (ADHD). It has also been shown to have positive results in treating anxiety associated with depression compared to other antidepressants (4).

What to do if Wellbutrin causes anger? 

 If you experience intense anger and agitation while taking Wellbutrin, it is important to talk to your healthcare provider. While these side effects often improve over time, individuals may respond differently.

If Wellbutrin is causing negative changes in your personality, it is important to discontinue its use. However, it is crucial that you do not stop taking Wellbutrin without consulting your doctor first. They will provide guidance and ensure a safe transition to an alternative medication if necessary.

What are some ways to manage anger and other side effects of Wellbutrin?

Some ways to manage anger and other side effects of Wellbutrin are (5,6): 

  • Maintain a healthy lifestyle – it is crucial to take good care of your health.
  • Practice stress-reducing techniques – stress can trigger behavioral  side effects and can make your depression worse.
  • Monitor your symptoms – it is important to know what kinds of side effects are common in your case.
  • Consider changing the time of taking your antidepressant – taking Wellbutrin at a different time may help manage some of the side effects.
  • Keep your doctor updated about your side effects – if side effects are severe and the drug is significantly affecting the quality of your life, you should talk to your doctor about changing or discontinuing the medication.


As mentioned earlier, Wellbutrin can lead to symptoms such as irritability, anxiety, and agitation. We have also provided information on how to manage and alleviate these symptoms.

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Chandler P, Herxheimer A. Unexpected aggressive behavior: Interaction of bupropion and alcohol. International Journal of Risk & Safety in Medicine. 2011;23(3):133–7.


‌WELLBUTRIN® (bupropion hydrochloride) Tablets. Prescribing Information [Internet].


Berigan TR. The Many Uses of Bupropion and Bupropion Sustained Release (SR) in Adults. Primary Care Companion to The Journal of Clinical Psychiatry [Internet]. 2002;4(1):30–2.


Verbeeck W, Bekkering GE, Van den Noortgate W, Kramers C. Bupropion for attention deficit hyperactivity disorder (ADHD) in adults. Cochrane Database of Systematic Reviews. 2017 Oct 2.


Fochtmann LJ, Gelenberg AJ. Guideline Watch: Practice Guideline for the Treatment of Patients With Major Depressive Disorder, 2nd Edition. FOCUS. 2005 Jan;3(1):34–42.


Kelly K, Posternak M, Jonathan EA. Toward achieving optimal response: understanding and managing antidepressant side effects. Dialogues in Clinical Neuroscience [Internet]. 2008 Dec 1;10(4):409–18.

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