Does Vyvanse cause nausea? 

Does Vyvanse cause nausea? 

Vyvanse may cause nausea in some individuals, especially those who are new to this medication. Vyvanse is an Amphetamine, which is a CNS stimulant. 

Such medications are known to cause gastrointestinal side effects, tiredness, and an overall feeling of sickness. However, these side effects are expected to subside on their own within a few weeks as your body adjusts to the medication. 

Make sure you report these side effects to your healthcare provider if they are severe or if they affect the quality of your life. Vyvanse can be taken along with other medications, like SSRI antidepressants, painkillers, some OTC medications, etc.

Taking it concomitantly with meds that can also cause nausea may increase the intensity of this side effect.

What does research suggest?

There is limited research on Vyvanse-induced nausea, but it is listed as one of the early side effects of this medication. Nausea with Vyvanse is not considered a dangerous side effect and researchers have indicated that new users are more susceptible to this effect (1). 

However, it is important to note that people are different and meds affect them differently, especially those which can alter brain chemistry, such as Vyvanse. 

Other factors like the patient’s age, dosage strength, severity of disease, any other underlying medical condition, and overall health can also contribute to the side effects.

What to do if Vyvanse causes nausea? 

The first thing to do if Vyvanse causes nausea is to make sure you don’t take this medication on an empty stomach. Taking your nausea-causing medication with meals is a common practice and it does help prevent some other gastrointestinal side effects as well, like acid reflux. 

Taking meds on an empty stomach causes rapid absorption and more significant effects, which can make you feel nauseous or sick overall. If taking Vyvanse with meals doesn’t help your nausea, reach out to your doctor. 

Make sure you don’t skip using Vyvanse because of the side effects. Meds that can affect your brain should never be used improperly. You can also try some natural ingredients, like peppermint, lemon, and ginger to help your nausea. 

If your nausea is persistent, your doctor may prescribe an antiemetic to take concomitantly with Vyvanse. Make sure you don’t start using any medication with Vyvanse on your own. 

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Goodman DW. Lisdexamfetamine dimesylate (vyvanse), a prodrug stimulant for attention-deficit/hyperactivity disorder. P T. 2010 May;35(5):273-87. PMID: 20514273; PMCID: PMC2873712. Available from: