Does Lexapro cause itchy skin? (+5 risk factors)

In this article, we will discuss whether Lexapro causes itchy skin or not, what the research studies have to say about it, and the link between Lexapro and itchy skin. In addition to this, the factors affecting the condition will also be discussed.

Does Lexapro cause itchy skin?

Yes, Lexapro can cause itchy skin as a potential side effect. Itchy skin may also indicate an allergic reaction to Lexapro and must be promptly reported to the healthcare provider.

Not everyone may experience this allergic reaction after taking Lexapro. Itchy skin most commonly known as pruritus is a potential but uncommon side effect of this antidepressant.

It is important to note that not everyone will develop itchy skin while taking Lexapro. It is important to consult your healthcare provider if you encounter such problems while taking Lexapro.

What does research suggest?

A research study conducted in 2022, suggested that while this side effect is relatively rare, it can still occur in patients more susceptible to it.

It may be dose-dependent with higher doses causing a relatively higher risk (1). In 2019, escitalopram was found to be the cause of a drug-induced rash in a patient who was taking Lexapro for anxiety and depression (2).

Research in 2015, suggested serotonin to be an important mediator of interaction between the neuroendocrine system and the skin. The mechanism may be immunological or non-immunological (3).

The major sources of serotonin in the skin are the platelets, which release serotonin upon activation. The released serotonin interacts with the membrane-bound serotonin and serotonin transporter receptors that are present in the skin cells.

Hence, this can be the reason for skin rash or itchy skin caused by increased serotonin levels due to Lexapro (4).

Mast cells are the immune cells that play a role in allergic reactions on the skin. When these cells are triggered, they release various substances including histamine and other inflammatory mediators (3).

Studies have suggested that serotonin may influence itching through specific receptor pathways such as the 5-Hydroxytryptamine (5-HT) receptor 7 and transient receptor potential ankyrin 1 (TRPA-1) ion channel (5).

What are the factors contributing to Lexapro-induced itchy skin?

Several factors can influence the occurrence of itchy skin while taking Lexapro. It is important to consider these factors to understand and manage the condition. The following are the factors:

Individual Variation

Each person’s body responds differently to medications, including antidepressants like Lexapro. Some individuals may be more prone to developing itchy skin as a side effect due to their unique psychological responses. These are greatly affected by genetic factors.

Dosage

The dose of Lexapro can influence the likelihood and severity of side effects including pruritus. Higher doses may be associated with a higher risk of side effects, but this can vary among individuals (6).

The normal dose of Lexapro is 10mg/day. It is recommended for both anxiety and depression as Lexapro is mainly used for anxiety treatments.

Duration of Use

Itchy skin may occur shortly after starting Lexapro or after taking Lexapro for an extended period. Some individuals may develop this side effect only after a few weeks or months of use. Lexapro takes about 1-4 weeks to start showing its effects.

Some of the side effects appear within this time when the body is trying to adjust to the effects of Lexapro.

Previous medication history

If you have previously taken other medications within the same drug class (SSRIs) such as Sertraline and fluoxetine or some other drugs that affect serotonin levels, your body’s levels of serotonin may get higher and then body’s response to Lexapro may result in itchy skin or pruritus.

Concurrent medication

The use of concurrent medications alongside Lexapro can interact with its effects and potentially contribute to side effects like itchy skin. The medications that may interact with Lexapro are:

• Other SSRIs as sertraline and fluoxetine
• Antipsychotics as olanzapine
• Benzodiazepines as alprazolam, lorazepam
• Antihistamines as loratidine, citrizine
• NSAIDs or opioid analgesics such as tramadol and ibuprofen
• OTC medications for cold remedies as dextromethorphan
• Dietary supplements as St. John’s Worts
• Some contraceptives as well.

Underlying condition

Certain medical conditions may make individuals more susceptible to skin-related effects. The medical conditions that may lead to itchy skin after administering Lexapro include:

• Liver dysfunctioning
• Kidney diseases
• Allergies
• Skin conditions such as eczema, psoriasis
• Autoimmune disorders such as lupus erythematosus and systemic sclerosis.
• Endocrine disorders
• Weak immune system

How to treat itchy skin experienced while taking Lexapro?

While taking Lexapro, if a patient experiences itchy skin then the following steps should be taken.

Consulting healthcare provider

Inform your healthcare provider about your conditions and the observed side effects. They can assess the severity evaluate the potential cause of itching and recommend appropriate intervention. Your doctor may suggest the following:

• Your healthcare provider may consider adjusting the dose of Lexapro or switching to an alternative antidepressant such as sertraline or fluoxetine.

• Over-the-counter anti-itch creams or ointments containing ingredients like hydrocortisone may be prescribed. They can provide temporary relief.

• Your doctor may suggest you keep a close eye on the allergens that trigger the skin itch. These may include laundry detergents, skin care products, fabrics etc.

• In severe cases, your healthcare provider may prescribe prescription-strength medications such as corticosteroids or oral antihistamines.

 Tips to manage itchy skin

The following tips can help manage the itchy skin:

• Applying a cool damp cloth or a cold compress can help soothe the skin and help with the itch.
• Moisturise the skin regularly with the fragrance-free hypoallergenic moisturiser to keep the skin healthy
• Choose loose-fitting, breathable clothing made of natural fabric like cotton to maintain itchy skin.
• Although it may be tempting, scratching can worsen the itch and potentially break the skin. Try to resist the itch.
• Hot water can exacerbate itching. Opt for lukewarm water during baths and showers and keep them brief.
• Keep a diary to record when the symptoms appear, their severity and potential triggers.

Conclusion

In my opinion, Lexapro can cause itchy skin although it is not a commonly observed side effect of taking Lexapro. Remember that itchy skin can result from various factors and managing it may require a combination of strategies but consulting the healthcare provider is first and foremost.

References