Does Lexapro cause anger? 

Does Lexapro cause anger? 

Lexapro (Escitalopram) may make you angry and cause other mood-related side effects. This is more common in people who are new to Lexapro or antidepressants in general. 

These medications work by increasing the number of excitatory neurotransmitters in your brain, which can make you feel different at first. The excitatory activity in the brain can make one angry, anxious, and agitated. 

However, these side effects begin to subside when Lexapro kicks in within 4-6 weeks. When your antidepressant finally starts to work, it elevates your mood, increases your energy levels, and makes you feel good overall. However, it can make you feel worse before making you feel better

What does research suggest?

Research suggests that Lexapro may have an impact on mood and emotions. While Lexapro is primarily prescribed to treat depression and anxiety, some individuals may experience mood disturbances, including increased irritability or anger. (1,2)

It’s important to note that these mood changes are not experienced by everyone and may vary from person to person. The exact reasons behind these mood disturbances are not fully understood and may depend on individual factors and the specific interaction between the medication and brain chemistry. 

If you are taking Lexapro and notice any changes in your mood, including increased anger or irritability, it is important to discuss this with your healthcare provider. They can evaluate your symptoms, assess the potential underlying causes, and make any necessary adjustments to your treatment plan.

Additionally, it’s important to follow the prescribed dosage and inform your doctor about any other medications or supplements you are taking. Some drug interactions may contribute to mood changes or intensify side effects.

Overall, Lexapro is generally well-tolerated and effective in managing depressive symptoms (3). It’s important to stay in close communication with your healthcare provider to monitor any changes in your mood or emotional well-being.

What to do if Lexapro makes you angry? 

Reach out to your healthcare provider if your antidepressant makes you angry beyond your control. A little anger every now and then is a part of our lives, but if your anger overpowers your sanity and emotions, that’s not a good sign. 

Lexapro is generally a well-tolerated antidepressant, but it may cause personality-related side effects in some individuals which can not always be tolerated. This is why it’s best to talk to your doctor and make sure that the use of Lexapro is not making negative changes in your personality. 

If it is, your doctor may make you stop using this medication. Make sure you don’t make any changes to your prescription without consulting your doctor first. 

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Garnock-Jones KP, McCormack PL. Escitalopram: a review of its use in the management of major depressive disorder in adults. CNS Drugs. 2010 Sep;24(9):769-96. doi: 10.2165/11204760-000000000-00000. PMID: 20806989.


Savaskan E, Müller SE, Böhringer A, Schulz A, Schächinger H. Antidepressive therapy with escitalopram improves mood, cognitive symptoms, and identity memory for angry faces in elderly depressed patients. Int J Neuropsychopharmacol. 2008 May;11(3):381-8. doi: 10.1017/S1461145707007997. Epub 2007 Aug 13. PMID: 17697395.


Landy K, Rosani A, Estevez R. Escitalopram. 2022 Oct 24. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2023 Jan–. PMID: 32491666.

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