Does Lexapro Affect The Immune System? (3+ Impacts)

By Ivan Kahwa

Page last updated: 05/02/2024 | Next review date: 05/02/2026

Author bio

Mr Ivan Kahwa is a chemist and phytopharmaceutical scientist with expertise in chemistry, pharmacology, phytochemistry, and Nanobiotechnology. He writes and reviews content on these topics.

Mr Ivan Kahwa’s Highlights:

Guest Researcher at the University of Leipzig, Senior Research Fellow/Scientist, and Lecturer at the Department of Pharmacy, Faculty of Medicine, Mbarara University of Science and Technology.

Professional Experience:

Mr Ivan joined PHARMBIOTRAC as a research fellow/scientist during his master of science tenure. He contributed to the development of most of the phytopharmaceutical products in the project. Furthermore, he participated in carrying out the pharmacological activities of the developed products in laboratory animals such as mice and rats in order to develop proper doses hence leading to pre-clinical studies.

With the above relevant research experience, Ivan started to work with the University of Leipzig on collaborative projects with Mbarara University to develop the chemistry of Ugandan Medicinal plants and their pharmacological activities. This was coupled with several consultative positions by different German NGOs. Mr. Kahwa is also a supporting in the teaching and learning at the Departments of Pharmacy and Pharmaceutical Sciences, Faculty of Medicine, Mbarara University of Science and Technology.

With the increase in antimicrobial resistance globally, Ivan retooled his thinking towards developing new naturally derived antibiotic regimens from Ugandan propolis with the assistance of nanotechnology to improve their delivery to microbial cells. Kahwa has also published over 28 articles in peer-reviewed journals and he is currently reviewing for many journals.

Education:

2023-2027: PhD in Pharmaceutical Sciences (ongoing) with a focus on Pharmaceutical Microbiology and Nanobiology at Mbarara University of Science and Technology.

2022: 2Msc. in Pharmacognosy and Natural Medicine Science at Mbarara University of Science and Technology.

2018: Bachelor of Science (Chemistry) at Mbarara University of Science and Technology.

Publications:

▪ Iqbal, S., Jabeen, F., Kahwa, I., & Omara, T. 2023. Suberosin Alleviates Thiazolidinedione-Induced Cardiomyopathy in Diabetic Rats by Inhibiting Ferroptosis via Modulation of ACSL4-LPCAT3 and PI3K-AKT Signaling Pathways. Cardiovascular Toxicology. https://doi.org/10.1007/s12012-023-09804-7

▪ Gupta, A. K., Yadav, R., Sharma, S., Sawale, J., & Kahwa, I. 2023. Anti-ageing Activity and Antioxidant Activity of Methanol Extracts of Leaves and Flowers of Salvia officinalis and Rosmarinus officinalis. Journal of Young Pharmacists, 15(3), 448–455. https://doi.org/10.5530/jyp.2023.15.60

▪ Tolo, C.U., Kahwa, I., Nuwagira, U., Weisheit, A. and Ikiriza, H., 2023. Medicinal plants used in treatment of various diseases in the Rwenzori Region, Western Uganda. Ethnobotany Research and Applications, 25, pp.1-16.

https://ethnobotanyjournal.org/index.php/era/article/view/4683

▪ Kahwa, I., Ajayi, C.O., Yadav, R., Chauhan, N.S., Shah, K., Abdelgadir, A.A., Shegena, E.A., Daniel, S., Omara, T., Asiimwe, J.B. and Ikiriza, H., 2023. Pharmacognostic and phytochemical studies as an invaluable approach for correct identification of medicinal plants: The case of Artemisia vulgaris L. substituted for Artemisia annua L. in Western Uganda. TMR Integr Med, 7, p.e23004.

https://doi.org/10.53388/TMRIM202307004

▪ Nalimu, F., Oloro, J., Kahwa, I. and Ogwang, P.E., 2021. Review on the phytochemistry and toxicological profiles of Aloe vera and Aloe ferox. Future Journal of Pharmaceutical Sciences, 7, pp.1-21.

https://doi.org/10.1186/s43094-021-00296-2

▪ Elamin, O.H.S., Ali, M.A., Elgezuli, I.A.A., Bashir, M.A. and Kahwa, I., 2021. Diagnosis of pre-and post-treatment of echinococcus granulosus with counter current immune electrophoresis and bacterial co-agglutination. Journal of Microbiology and Infectious Diseases, 11(02), pp.88-94.

https://doi.org/10.5799/jmid.951600

Published book Chapter

▪ Kahwa, I., Ayesiga, I., Nakalema, S., Alinaiswe, R., Mbabazi, R. and Iqbal, S., 2023. Natural products in the management of onchocerciasis. In Natural Products in Vector-Borne Disease Management (pp. 63-80). Academic Press. Book Chapter.

https://doi.org/10.1016/B978-0-323-91942-5.00012-4

Submitted manuscripts Under Review:

▪ Comparison of the Wound Healing Activity of the Leaf and Leaf Ash Extracts of Vernonia amygdalina in Rats. Journal name: Clinical Phytoscience

▪ Ethnobotanical Survey of Medicinal plants used in the management of cancer in Uganda. Journal name: Journal of Herbal Medicine

▪ Ethnobotanical survey and phytochemical screening of medicinal plants used in treatment of epilepsy by PROMETRA-Uganda Traditional Health Practitioners in Mpigi District, Uganda. Journal name: Journal of Ethnopharmacology

Submitted book chapters under review

1.Book title: Algae as a Natural Solution for Water-Food-Energy Nexus, Section 4: Microalgae and cyanobacteria for food applications, Chapter 4.6: Safety, toxicological and allergenic aspects of using algae for food. Authors: Christine Kyarimpa, Tom Omute, Caroline K. Nakiguli, Alice V. Khanakwa4, Christopher Angiro, Ivan Kahwa, Fortunate Ahumuza, Timothy Omara*. Publisher: Springer Nature Singapore Pte Ltd. 152 Beach Road, #21-01/04 Gateway East, Singapore 189721, Singapore.

2.Book title: Nutraceuticals Inspiring the Contemporary Therapy for Lifestyle Diseases. Chapter: Nutraceutical applications of Seaweeds and their Phytocompounds in Nutrition and Treatment of Diseases. Authors: Ivan Kahwa, Timothy Omara , Innocent Ayesiga , Gael Noel Neh Neba Ambe , Zehbanaz Javidbhai Panwala , Rachel Mbabazi , Shabnoor Iqbal , Christine Kyarimpa , Christine Betty Nagawa , Kamal Shah ,Nagendra Singh Chauhan* Publisher: CRC Press

You can view my works on the following professional sites:

Research Gate: https://www.researchgate.net/profile/Ivan-Kahwa

Google Scholar: https://scholar.google.com/citations?user=tOwrvqoAAAAJ&hl=en

ORCID: https://orcid.org/0000-0002-6440-3437

Linkedin: https://de.linkedin.com/in/ivan-kahwa-865450159

Ivan Kahwa

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In this article, we will discuss whether Lexapro affects the immune system or not. We will also discuss what research suggests on this, the relationship between mental health and the immune system, the potential impact of Lexapro on the immune system, common side effects of Lexapro and tips for managing the immune system while taking Lexapro.

Does Lexapro affect the immune system?

Yes, Lexapro (escitalopram) may indirectly affect the immune system in some individuals in both positive and negative ways. SSRIs like Lexapro may help modulate inflammation which could have indirect effects on the immune system. However, the specific mechanisms are not fully understood. (1)

Lexapro is an antidepressant which belongs to the class of drugs known as selective serotonin reuptake inhibitors (SSRIs). It is primarily used for the treatment of depression and anxiety by increasing the levels of a neurotransmitter called serotonin in the brain that helps improve mood. (3)

Chronic stress and untreated mental health conditions can negatively impact the immune system. By effectively managing these conditions, Lexapro may indirectly contribute to immune system health. (4)

If you have concerns about how Lexapro may be affecting your immune system or if you’re experiencing any side effects, it’s crucial to discuss these with your healthcare provider.

What does research suggest?

According to research, a clinical trial was conducted on 15 people with major depression, 11 women and 4 men. The researchers measured different types of white blood cells before and after these people took escitalopram for 8 weeks. (2)

Results showed that there was a significant decrease in the number of one white blood cell (40-60%), called lymphocytes after 8 weeks of taking escitalopram. Other types of WBCs did not change much. (2)

White blood cells are also called leukocytes, they attack and destroy germs and other invaders like virus and bacteria that enters into your body to make you sick. They are involved in the defence mechanism of your body.

In simple terms, the study suggests that taking escitalopram for depression might lower lymphocytes. This means that if someone has immune system issues, using escitalopram for depression might need careful consideration. (2)

What is the relationship between Lexapro and immune function?

The relationship between Lexapro and immune function is complex and multifaceted. Lexapro is commonly prescribed as SSRIs to treat depression and anxiety by affecting neurotransmitters in the brain. (5)

The immune system and mental health are interconnected, and conditions like depression and chronic stress may impact a person’s immune system. In some cases, SSRIs like Lexapro have been associated with anti-inflammatory effects and they may modulate certain aspects of the immune response. (5)

However, the specific mechanisms and implications of these side effects are still under investigation. It’s important to note that an individual’s responses to medications can vary and the relationship between Lexapro and the immune system is likely to be complex.

What is the impact of Lexapro on the immune system?

The potential impact of Lexapro (escitalopram) on the immune system involves several factors, including: (4,5)

Anti-inflammatory effects:

Some studies suggest that SSRIs, including Lexapro, may have anti-inflammatory properties. Chronic inflammation is associated with various health conditions, so a potential anti-inflammatory effect could indirectly contribute to overall health, including immune function.

Indirect effects through mental health improvement:

Lexapro is primarily prescribed for the treatment of depression and anxiety. Mental health and immune function are interconnected, and treating these conditions may positively influence immune system health indirectly.

Individual variations:

Responses to medications can vary among individuals and the impact on the immune system may differ from person to person.

If you have any concerns about the potential impact of Lexapro on your immune system, it’s recommended to discuss them with your doctor. They can provide the most up-to-date information and personalized guidance based on your specific health profile.

What are the common side effects of Lexapro?

The common side effects of Lexapro may include: (3)

Nausea
Insomnia or sleep disturbances
Fatigue
Drowsiness
Dizziness
Headache
Dry mouth
Sweating
Changes in weight (weight gain and weight loss)
Sexual side effects (changes in libido)
Gastrointestinal issues (upset stomach, diarrhoea, constipation)

It’s important to note that not everyone will experience these side effects and everyone responds differently to medications.

How to manage the immune system while taking Lexapro?

While taking Lexapro (escitalopram), it’s essential to focus on your overall health and well-being which can indirectly support a healthy immune system. Here are some general tips for managing your immune system while taking Lexapro: (1,4,5)

Follow the prescribed dosage: Take Lexapro as prescribed by your doctor. Do not adjust the dosage or stop taking it without consulting your doctor.
Regular medical checkups: Attend regular check-ups with your healthcare provider to monitor your overall health, including any potential side effects or changes in your condition.
Maintain a healthy lifestyle: Eat a balanced diet rich in nutrients like fruits, vegetables, whole grains and proteins. Engage yourself in regular physical activity as exercise can improve immune function.
Manage stress: Practice deep breathing, meditation, yoga or mindfulness to reduce stress.
Stay hydrated: Drink plenty of water to maintain proper hydration which is essential for overall health.
Practice good hygiene: Wash your hands regularly to prevent the spread of infections. Practice good respiratory hygiene, especially during flu season.
Limit alcohol consumption: Avoid alcohol and the use of illicit substances, as they can weaken your immune system.
Communicate with your healthcare provider: Tell them about any new or unusual symptoms that you may experience and discuss concerns about medication side effects or interactions.

In my opinion, always consult with your healthcare provider for guidance tailored to your specific health needs and any potential interactions between Lexapro and your overall health.