Does Fluoxetine liquid need to be refrigerated? (+5 risks)

In this brief article, we will answer the question, “Does Fluoxetine liquid need to be refrigerated?” and other questions, like What is the proper storage guideline for fluoxetine liquid?; What is the shelf life of fluoxetine liquid? and How to know if Fluoxetine liquid has gone bad?

Does Fluoxetine liquid need to be refrigerated?

No, Fluoxetine liquid does not need to be refrigerated. A fluoxetine liquid is an oral solution form of the medication fluoxetine (Prozac). The oral solution is formulated with 20 mg of fluoxetine per 5 ml.

Generally, many liquid medications including some formulations of fluoxetine do not require refrigeration. However, always follow the storage guidelines provided by the medication’s packaging or your healthcare provider to ensure its stability and effectiveness. If refrigeration is necessary, the instructions will be specified. 

Can Fluoxetine liquid be refrigerated during a hot day?

High temperatures, coupled with moisture have the potential to compromise the potency of medications, leading to a decrease in effectiveness, even before the stated expiration date. (1)

Hence, in the presence of excessively elevated temperatures, refrigeration can be considered a precautionary measure.

However, the recommended storage temperature for fluoxetine falls between 20 degrees to 25 degrees Celsius (68 degrees to 77 degrees Fahrenheit). This suggests that the maximum temperature for storing fluoxetine liquid is 25 degrees Celsius or 77 degrees Fahrenheit. (2)

If fluoxetine oral solution is exposed to temperatures higher than the specified range, there is a risk of degradation. 

What is the proper storage guideline for fluoxetine liquid?

Liquid Fluoxetine must be used and stored according to the guidelines provided. Following medication storage requirements ensures potency, safety and accurate dosing, safeguarding against degradation and contamination and promoting positive health outcomes.

The storage requirements for fluoxetine are as follows: 

  • Protect the fluoxetine oral solution from light exposure. (2)


  • Keep the fluoxetine oral solution bottle tightly closed and store it in a cupboard, away from heat and direct sunlight. Refrigeration is unnecessary. (2,3)


  • Ensure that children cannot see or reach the medicine. (3)


  • Store the medicine in its original container. (3)

Improperly storing fluoxetine liquid may lead to reduced efficacy, altered composition, safety issues, inaccurate dosing, contamination, allergic reactions and negative health outcomes. 

What is the shelf life of fluoxetine liquid?

Shelf life refers to the period during which fluoxetine liquid is expected to remain stable, effective and safe for use under proper storage conditions. It is the duration from the manufacturing date until the expiration date, beyond which the manufacturer cannot guarantee the product’s quality. 

The shelf life of fluoxetine liquid is 3 years for a closed bottle and 1 month for an open bottle. After one month of opening the bottle, fluoxetine liquid should not be used. 

How to know if fluoxetine liquid has gone bad?

  • Examine the colour, clarity and consistency of the liquid. Any changes such as discolouration, cloudiness, or the presence of particles may suggest deterioration.


  • If the fluoxetine liquid develops a strange odour, it could be an indication of contamination or chemical changes.


  • Check the expiration date on the packaging.


  • If the liquid separates into distinct layers or forms clumps, it may indicate a loss of homogeneity or degradation.


  • Any significant changes in flavour, increased bitterness or an unusual taste could suggest spoilage. 


In this brief article, we have answered the question, “Does fluoxetine liquid need to be refrigerated?” and other questions, like what is the proper storage guideline for fluoxetine liquid, what is the shelf life of fluoxetine liquid and how to know if fluoxetine liquid has gone bad. 

I suggest not refrigerating the fluoxetine liquid; instead, store it at room temperature. I would advise to follow the given guidelines to ensure the medication’s effectiveness. 


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National Institutes of Health. (n.d.). DailyMed – fluoxetine- fluoxetine hydrochloride liquid. U.S. National Library of Medicine.



Information for parents and carers fluoxetine for depression, obsessive … (n.d.-b).


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