Can Prozac pills be cut in half? (3+ answers)

In this article, we will discuss if Prozac pills can be split in half for oral administration. We will also focus on the risks and consequences of cutting or splitting medications.

Can Prozac pills be cut in half?

Yes, Prozac (fluoxetine) pills can be cut in half. It does not pose a serious issue if the cut made is not completely equal. Prozac provides a little edge in case of uneven dose distribution. (1)

Therefore, if dose reduction is necessary and the required dose formulation is not available, Prozac pills can be cut in half. It is to be made sure that the dose adjustment is being done by the healthcare professional.

Most of the time the tablets are scored and can be split easily by applying a little force. If not, you can invest in a pill cutter or use a sharp knife available at home. 

Risks associated with cutting Prozac pills in half

The typical dosage for patients under 18 years of age is 10-20 mg per day whereas for adults it is 20-80 mg per day. Any dose above 80 mg would potentially result in an overdose and may lead to serious side effects.

There are no risks associated with cutting Prozac pills because a slightly uneven cut would not result in an overdose and would not lead to side effects that may be detrimental to the patient.

Some other risks and concerns should be kept in mind while storing the other half of the medication. If left open, without proper storage, the other half of the tablet will absorb moisture and make it unpalatable.

It is recommended that the medication be only split when it is time for the person to take it and not before. Also, store the other half of the medicine in an airtight container.

Pros and cons of cutting Prozac tablets

The positive outcome of cutting a Prozac tablet would be to get the desired dose from the already available tablets at home which would also be cost-effective.

The undesirable outcome would be to have to cut the tablet every time before administration which will contribute to extra work.

Storage of the other half of the tablet can be an issue as well. It would require a proper air-tight container for its storage so that the moisture would not seep into the tablet.

Alternatives to cutting Prozac

In case you find cutting Prozac pills in half difficult, you can always ask the pharmacist to make a dose adjustment for your prescription or you can opt for the oral liquid form available for this medication. 

Prozac is available in liquid form with a dosage formulation of 20 mg/5 ml of fluoxetine solution. Oral liquid forms help make the adjustment of dose much more easier and convenient for the patient.

Why is it best to talk to healthcare professionals?

It is very important to involve healthcare professionals when making any decision related to health or medication. Every drug is manufactured differently with external coating for different purposes. So, breaking the tablet without proper knowledge could result in disrupting the function of the medicine.

The healthcare providers will provide alternative and better options which would be more helpful for the situation. 

Common side effects experienced with Prozac

Prozac is very well-known to be used for anxiety and mood disorders such as obsessive-compulsive disorder. It has been reported to have fewer cardiovascular side effects and also is considered to be less harmful in case of an overdose in comparison to tricyclic antidepressants.

Some of the commonly reported adverse effects of Prozac are listed below:

  • Insomnia
  • Headache
  • Nausea
  • Anxiety
  • Nervousness
  • Dry mouth
  • Somnolence
  • Rhinitis
  • Tremor


In my perspective, cutting Prozac tablets is not dangerous but it is not recommended without discussing it with your healthcare provider or pharmacist.

Proper care should be taken in terms of storage for the other half of the table to prevent it from going bad as it can absorb moisture and might result in bitterness.

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Keks N, Hope J, Keogh S. Switching and stopping antidepressants. Aust Prescr. 2016 Jun;39(3):76-83. doi: 10.18773/austprescr.2016.039. Epub 2016 Jun 1. PMID: 27346915; PMCID: PMC4919171.

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