Does citalopram cause hives? (5 factors)
By
Ivan Kahwa
Author bio
Mr Ivan Kahwa is a chemist and phytopharmaceutical scientist with expertise in chemistry, pharmacology, phytochemistry, and Nanobiotechnology. He writes and reviews content on these topics.
Mr Ivan Kahwa’s Highlights:
Guest Researcher at the University of Leipzig, Senior Research Fellow/Scientist, and Lecturer at the Department of Pharmacy, Faculty of Medicine, Mbarara University of Science and Technology.
Professional Experience:
Mr Ivan joined PHARMBIOTRAC as a research fellow/scientist during his master of science tenure. He contributed to the development of most of the phytopharmaceutical products in the project. Furthermore, he participated in carrying out the pharmacological activities of the developed products in laboratory animals such as mice and rats in order to develop proper doses hence leading to pre-clinical studies.
With the above relevant research experience, Ivan started to work with the University of Leipzig on collaborative projects with Mbarara University to develop the chemistry of Ugandan Medicinal plants and their pharmacological activities. This was coupled with several consultative positions by different German NGOs. Mr. Kahwa is also a supporting in the teaching and learning at the Departments of Pharmacy and Pharmaceutical Sciences, Faculty of Medicine, Mbarara University of Science and Technology.
With the increase in antimicrobial resistance globally, Ivan retooled his thinking towards developing new naturally derived antibiotic regimens from Ugandan propolis with the assistance of nanotechnology to improve their delivery to microbial cells. Kahwa has also published over 28 articles in peer-reviewed journals and he is currently reviewing for many journals.
Education:
2023-2027: PhD in Pharmaceutical Sciences (ongoing) with a focus on Pharmaceutical Microbiology and Nanobiology at Mbarara University of Science and Technology.
2022: 2Msc. in Pharmacognosy and Natural Medicine Science at Mbarara University of Science and Technology.
2018: Bachelor of Science (Chemistry) at Mbarara University of Science and Technology.
Publications:
▪ Iqbal, S., Jabeen, F., Kahwa, I., & Omara, T. 2023. Suberosin Alleviates Thiazolidinedione-Induced Cardiomyopathy in Diabetic Rats by Inhibiting Ferroptosis via Modulation of ACSL4-LPCAT3 and PI3K-AKT Signaling Pathways. Cardiovascular Toxicology. https://doi.org/10.1007/s12012-023-09804-7
▪ Gupta, A. K., Yadav, R., Sharma, S., Sawale, J., & Kahwa, I. 2023. Anti-ageing Activity and Antioxidant Activity of Methanol Extracts of Leaves and Flowers of Salvia officinalis and Rosmarinus officinalis. Journal of Young Pharmacists, 15(3), 448–455. https://doi.org/10.5530/jyp.2023.15.60
▪ Tolo, C.U., Kahwa, I., Nuwagira, U., Weisheit, A. and Ikiriza, H., 2023. Medicinal plants used in treatment of various diseases in the Rwenzori Region, Western Uganda. Ethnobotany Research and Applications, 25, pp.1-16.
https://ethnobotanyjournal.org/index.php/era/article/view/4683
▪ Kahwa, I., Ajayi, C.O., Yadav, R., Chauhan, N.S., Shah, K., Abdelgadir, A.A., Shegena, E.A., Daniel, S., Omara, T., Asiimwe, J.B. and Ikiriza, H., 2023. Pharmacognostic and phytochemical studies as an invaluable approach for correct identification of medicinal plants: The case of Artemisia vulgaris L. substituted for Artemisia annua L. in Western Uganda. TMR Integr Med, 7, p.e23004.
https://doi.org/10.53388/TMRIM202307004
▪ Nalimu, F., Oloro, J., Kahwa, I. and Ogwang, P.E., 2021. Review on the phytochemistry and toxicological profiles of Aloe vera and Aloe ferox. Future Journal of Pharmaceutical Sciences, 7, pp.1-21.
https://doi.org/10.1186/s43094-021-00296-2
▪ Elamin, O.H.S., Ali, M.A., Elgezuli, I.A.A., Bashir, M.A. and Kahwa, I., 2021. Diagnosis of pre-and post-treatment of echinococcus granulosus with counter current immune electrophoresis and bacterial co-agglutination. Journal of Microbiology and Infectious Diseases, 11(02), pp.88-94.
https://doi.org/10.5799/jmid.951600
Published book Chapter
▪ Kahwa, I., Ayesiga, I., Nakalema, S., Alinaiswe, R., Mbabazi, R. and Iqbal, S., 2023. Natural products in the management of onchocerciasis. In Natural Products in Vector-Borne Disease Management (pp. 63-80). Academic Press. Book Chapter.
https://doi.org/10.1016/B978-0-323-91942-5.00012-4
Submitted manuscripts Under Review:
▪ Comparison of the Wound Healing Activity of the Leaf and Leaf Ash Extracts of Vernonia amygdalina in Rats. Journal name: Clinical Phytoscience
▪ Ethnobotanical Survey of Medicinal plants used in the management of cancer in Uganda. Journal name: Journal of Herbal Medicine
▪ Ethnobotanical survey and phytochemical screening of medicinal plants used in treatment of epilepsy by PROMETRA-Uganda Traditional Health Practitioners in Mpigi District, Uganda. Journal name: Journal of Ethnopharmacology
Submitted book chapters under review
1.Book title: Algae as a Natural Solution for Water-Food-Energy Nexus, Section 4: Microalgae and cyanobacteria for food applications, Chapter 4.6: Safety, toxicological and allergenic aspects of using algae for food. Authors: Christine Kyarimpa, Tom Omute, Caroline K. Nakiguli, Alice V. Khanakwa4, Christopher Angiro, Ivan Kahwa, Fortunate Ahumuza, Timothy Omara*. Publisher: Springer Nature Singapore Pte Ltd. 152 Beach Road, #21-01/04 Gateway East, Singapore 189721, Singapore.
2.Book title: Nutraceuticals Inspiring the Contemporary Therapy for Lifestyle Diseases. Chapter: Nutraceutical applications of Seaweeds and their Phytocompounds in Nutrition and Treatment of Diseases. Authors: Ivan Kahwa, Timothy Omara , Innocent Ayesiga , Gael Noel Neh Neba Ambe , Zehbanaz Javidbhai Panwala , Rachel Mbabazi , Shabnoor Iqbal , Christine Kyarimpa , Christine Betty Nagawa , Kamal Shah ,Nagendra Singh Chauhan* Publisher: CRC Press
You can view my works on the following professional sites:
Research Gate: https://www.researchgate.net/profile/Ivan-Kahwa
Google Scholar: https://scholar.google.com/citations?user=tOwrvqoAAAAJ&hl=en
ORCID: https://orcid.org/0000-0002-6440-3437
Linkedin: https://de.linkedin.com/in/ivan-kahwa-865450159
In this article, we will explore whether citalopram causes hives. We will also talk about the contributing factors, the management strategies for citalopram-induced hives, and what should be done if hives persist.
Does citalopram cause hives?
Citalopram can cause hives, but it is not a common side effect. Individuals who are sensitive to citalopram or related antidepressants may experience allergic reactions such as hives, rashes, blisters, or other skin-related issues.
Citalopram belongs to the selective serotonin reuptake inhibitor (SSRI) class of drugs. Citalopram, also known as Celexa, works by blocking the reuptake of serotonin in the synaptic regions of the brain. Serotonin, a neurotransmitter regulates sleep, mood, emotions, appetite, memory, and the body’s response to stressful situations (1).
Hives, also known as urticaria, is a skin condition in which you may observe symptoms such as redness, and itchy bumps on the skin. You may experience hives which can be triggered by some food groups to which you are allergic, some insect bite, or a reaction to medicine. There are two kinds of hives; acute hives may take a few days to subside; however, chronic hives may remain for longer periods (2).
What factors contribute to citalopram-induced hives?
The contributing factors to citalopram-induced hives may include:
- If you have a history of allergy to antidepressants, especially selective serotonin reuptake inhibitors, you may be more prone to experience hives with citalopram.
- If you have ever experienced hives due to an unknown trigger, being allergic to some foods, or may be an insect bite, there are more chances that you may experience hives again.
- Some drugs when used in combination with citalopram, may have a drug interaction and cause reactions such as blisters, redness, or swelling.
- Some patients are sensitive to citalopram due to their specific genetic makeup and physiological responses, therefore they may respond differently to citalopram and develop skin-related issues.
- Use of citalopram at higher doses for extended periods may increase the risk of developing hives in some individuals (3).
It is important to note that not everyone taking citalopram may experience hives. However, if you suspect any allergic reaction while taking citalopram or any other medicine, you should immediately seek medical attention.
What are the management strategies for citalopram-induced hives?
The management strategies for citalopram-induced hives are discussed below:
Pharmacological treatment for hives
Your doctor may prescribe antihistamines which are the first line of treatment for citalopram-induced hives. You may get the most benefit from antihistamines when you are experiencing hives for a short duration.
If your condition and symptoms of citalopram-induced hives do not get better with antihistamines, your doctor may prescribe corticosteroids such as prednisone for hives. However, corticosteroids should only be used for short-term treatment (4,5).
Antihistamines and corticosteroids are prescription drugs and should only be taken if prescribed by your healthcare provider. Your doctor will determine which treatment is best for you to treat citalopram-induced hives depending on the severity of your symptoms.
Non-pharmacological treatment for hives
The non-pharmacological ways of managing citalopram-induced hives may include:
- You should avoid going out in the sun when you are experiencing hives.
- You should wear loose clothes to avoid itching, tight clothes may make you feel more uncomfortable.
- Citalopram may also cause dry skin, therefore take a shower with normal water to prevent the worsening of hives.
- You should use a rich moisturiser to avoid dryness.
- Avoid scrubbing with harsh soaps as it may worsen your condition.
- Be vigilant for triggers and avoid them such as certain food groups, insect bites, or stress.
- Try to reduce your stress levels by practising yoga, breathing exercises, or meditation, it may also help you to feel better and stay relaxed (6).
What to do if citalopram-induced hives persist?
If citalopram-induced hives persist, your healthcare provider may suggest gradually discontinuing citalopram and switching you to an alternative antidepressant which might be suitable for you.
Antidepressant treatment mainly involves a trial and error phase as one medication effective for one individual might not be suitable for another. Therefore, if you observe any side effects or skin-related issues while using citalopram, inform your healthcare provider immediately.
As per my analysis, citalopram can cause hives in susceptible individuals. Hives can be experienced by individuals who have a history of skin-related issues, allergic reactions to selective serotonin reuptake inhibitors, or allergic to certain foods.
If you notice any allergic reaction, please immediately reach out to your healthcare provider. They will evaluate your current symptoms, family or medical history, and take appropriate actions necessary to manage your condition. These management strategies may include pharmacological and non-pharmacological approaches depending on the severity of your symptoms.
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References
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Sharbaf Shoar N, Fariba KA, Padhy RK. Citalopram. 2023 Nov 7. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2023 Jan–. PMID: 29489221. Available from: https://pubmed.ncbi.nlm.nih.gov/29489221/
2.-
Kolkhir P, Giménez-Arnau AM, Kulthanan K, Peter J, Metz M, Maurer M. Urticaria. Nat Rev Dis Primers. 2022 Sep 15;8(1):61. doi: 10.1038/s41572-022-00389-z. PMID: 36109590. Available from: https://pubmed.ncbi.nlm.nih.gov/36109590/
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Kayiran MA, Akdeniz N. Diagnosis and treatment of urticaria in primary care. North Clin Istanb. 2019 Feb 14;6(1):93-99. doi: 10.14744/nci.2018.75010. PMID: 31180381; PMCID: PMC6526977. Available from: https://pubmed.ncbi.nlm.nih.gov/31180381/
4.-
Ring J, Brockow K, Ollert M, Engst R. Antihistamines in urticaria. Clin Exp Allergy. 1999 Mar;29 Suppl 1:31-7. doi: 10.1046/j.1365-2222.1999.00006.x. PMID: 10209703. Available from: https://pubmed.ncbi.nlm.nih.gov/10209703/
5.-
Asero R, Tedeschi A. Usefulness of a short course of oral prednisone in antihistamine-resistant chronic urticaria: a retrospective analysis. J Investig Allergol Clin Immunol. 2010;20(5):386-90. PMID: 20945604. Available from: https://pubmed.ncbi.nlm.nih.gov/20945604/
6.-
Kulthanan K, Tuchinda P, Chularojanamontri L, Chanyachailert P, Korkij W, Chunharas A, Wananukul S, Limpongsanurak W, Benjaponpitak S, Wisuthsarewong W, Aunhachoke K, Wessagowit V, Chatchatee P, Wattanakrai P, Jirapongsananuruk O, Klaewsongkram J, Noppakun N, Vichyanond P, Suthipinittharm P, Ruxrungtham K, Singalavanija S, Ngamphaiboon J. Clinical practice guideline for diagnosis and management of urticaria. Asian Pac J Allergy Immunol. 2016 Sep;34(3):190-200. PMID: 27690471. Available from: https://pubmed.ncbi.nlm.nih.gov/27690471/
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