Does citalopram cause a sore throat? (+5 factors)

 In this article, we will discuss whether citalopram causes a sore throat. Additionally, we will explore relevant studies that investigate the potential link between the use of citalopram and the occurrence of a sore throat. Furthermore, we will delve into the risk factors that may increase the likelihood of developing a sore throat while on citalopram. Finally, we will discuss the management strategies for sore throat if it occurs during citalopram treatment.

Does citalopram cause a sore throat?

Citalopram may cause a sore throat. However, this is not a common side effect of this medication. The primary mechanism of citalopram is to increase the levels of serotonin, which is thought to help alleviate symptoms of depression and anxiety. However, changes in serotonin levels may affect various bodily functions, and individual reactions can be diverse (1). 

It’s important to note that serotonin is also involved in various physiological processes, and alterations in its levels can have different effects on different people. If you are experiencing a sore throat while taking citalopram or have concerns about potential side effects, it’s crucial to consult with your healthcare provider.

What does research suggest?

There is limited research on sore throat as a side effect of citalopram. Individual responses to medications are diverse, and some people may indirectly experience side effects like a sore throat from citalopram that are not typically listed in the documentation.

 A research study explored the use of citalopram in the management of agitative and impulsive behavior in patients with underlying Alzheimer’s disease. The results indicated that, over a treatment period of 2 months, patients reported various side effects related to this medication. While the overall incidence of sore throat was low, approximately 7% of participants reported experiencing this side effect after using citalopram (2).

What factors may increase the risk of citalopram-induced sore throat?

Several factors may contribute to an increased risk of experiencing a sore throat while on citalopram (or any selective serotonin reuptake inhibitor, SSRI), including:

Individual sensitivity  People react differently to medications, and individual sensitivity can vary. Some individuals may be more prone to developing side effects, including throat irritation when taking citalopram. 
Concurrent medications Interactions between citalopram and other medications may influence the likelihood of side effects. For example, certain medications, such as nonsteroidal anti-inflammatory drugs (NSAIDs) or other antidepressants like bupropion, could potentially contribute to throat irritation when taken concurrently with citalopram. 
Underlying medical conditions Pre-existing medical conditions may increase the risk of side effects. Individuals with conditions affecting the throat or respiratory system, such as allergies, asthma, or chronic respiratory infections, may be more susceptible to experiencing a sore throat.

What to do if citalopram causes a sore throat?

If you develop a sore throat after taking citalopram, it’s crucial to consult your healthcare provider promptly. They will assess your condition to determine if citalopram is causing your symptoms and identify any contributing risk factors.

If citalopram is responsible for your sore throat, your healthcare provider may suggest adjusting the dosage, especially if a higher dose is linked to these side effects. Alternatively, they might consider switching you to a different antidepressant based on your individual needs.

It’s important to emphasize that stopping citalopram without consulting your healthcare provider is not recommended if you experience any side effects. Instead, have a conversation with your healthcare provider to discuss the issues you’re facing.

They can provide guidance, recommend medications, or suggest interventions to address the side effects and ensure your well-being. 

What are the management tips for citalopram-induced sore throat?

While a sore throat rarely occurs with citalopram, here are some management tips if you experience such side effects after using citalopram:

  • Stay hydrated by drinking plenty of fluids.
  • Gargle with warm saltwater.
  • Use throat lozenges or hard candies to soothe the throat.
  • Avoid irritants like tobacco smoke.
  • Rest your voice and avoid shouting or whispering.
  • Maintain good oral hygiene.
  • Try steam inhalation to ease throat discomfort.
  • Rinse your sinuses with a saline solution.
  • Consider honey and ginger tea for its soothing properties.
  • Stay well-hydrated with water, herbal teas, and broths.
  • Maintain a comfortable room temperature. void acidic beverages like citrus juices.
  • Avoid excessive throat clearing, which can irritate.
  • Follow your healthcare provider’s recommendations for any prescribed treatments.

In my experience

In my experience, patients rarely report sore throats after using citalopram in the clinical setting. However, individual responses to medications may vary and if you experience such side effects with citalopram, consult your healthcare provider for a proper diagnosis and management of your symptoms. 

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References

1.-

Sharbaf Shoar N, Fariba KA, Padhy RK. Citalopram. [Updated 2023 Nov 7]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2023 Jan-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK482222/

2.-

Porsteinsson AP, Drye LT, Pollock BG, Devanand DP, Frangakis C, Ismail Z, Marano C, Meinert CL, Mintzer JE, Munro CA, Pelton G, Rabins PV, Rosenberg PB, Schneider LS, Shade DM, Weintraub D, Yesavage J, Lyketsos CG; CitAD Research Group. Effect of citalopram on agitation in Alzheimer disease: the CitAD randomized clinical trial. JAMA. 2014 Feb 19;311(7):682-91. doi: 10.1001/jama.2014.93. PMID: 24549548; PMCID: PMC4086818. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4086818/

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