Does Wellbutrin-induced sore throat go away? (3+ tips)

This article will discuss the question, “Can Wellbutrin-induced sore throat go away?” What researchers have to say about the side effects of Wellbutrin and how you can reduce the difficulty caused by a sore throat.

Does Wellbutrin-induced sore throat go away?

Yes, a sore throat caused by Wellbutrin subsides within a week or two. Wellbutrin-induced sore throat is not considered a common side effect, but some people may experience it when they start taking this antidepressant.

It generally takes some time for your body to adjust to the antidepressant. Wellbutrin-induced sore throat usually subsides on its own.

You may also experience other common side effects like headache, dry mouth, insomnia, agitation, nausea, vomiting and constipation. These side effects vary from person to person.

If you are experiencing a sore throat or any other side effects for longer, talk to your healthcare professional for proper management.

What does research suggest?

Wellbutrin (Bupropion) is an antidepressant that inhibits dopamine reuptake and increases dopamine levels in the brain. It also has some effect on other receptors like serotonin and nicotine. (1) It is common to experience side effects at the beginning of treatment.

Stopping the medication suddenly can make you experience discontinuation syndrome, which includes flu-like symptoms, dizziness, insomnia, anxiety, nausea and sensory disturbance. (2)

Common side effects improve in the first two weeks of treatment as your body adjusts to the medication. (3) Do not discontinue Wellbutrin on your own because of the side effects you experience. Talk to your healthcare provider about your concerns and get a proper treatment.

What factors can contribute to sore throat while taking Wellbutrin?

The factors contributing to sore throat while taking Wellbutrin include:

Smoking cessation: Wellbutrin is sometimes prescribed to help quit smoking. Smoking cessation may cause throat irritation and coughing, which may contribute to a sore throat.

Allergic reaction: In rare cases, an allergic reaction to Wellbutrin can manifest as a sore throat, along with other symptoms like rash, itching and swelling.

Medical conditions: Pre-existing conditions like Gastroesophageal Reflux Disease (GERD), which increases the risk of acid reflux and infections such as flu and measles, can lead to throat irritation or sore throat.

Dry mouth: Wellbutrin can cause dry mouth as a common side effect. A dry mouth can make the throat feel dry and irritated, leading to a sore throat.

What to do if Wellbutrin causes a sore throat?

If you are experiencing a sore throat while taking Wellbutrin, it is essential to address it properly. Here are some home remedies you can use to deal with sore throat.

Lozenges: Over-the-counter sore throat lozenges can help reduce the discomfort caused by sore throat. Lozenges increase saliva and help decrease dryness and itchiness in your throat. Medicated lozenges also help you get quick relief from pain.

Warm salt water gargle: Gargling with warm salt water can provide relief. Mix half a teaspoon of salt in warm water and gargle 3-4 times daily. The saltwater helps reduce inflammation and soothes your throat.

Humidifier: Use a humidifier in your room; adding moisture to your air will help ease your pain. You can also use steam inhalation to loosen up mucus, soothe your throat and improve hoarseness.

Avoid irritants: Avoid smoking and exposure to smoke, which may irritate your throat. Avoid drinking alcohol and caffeine since they may dehydrate your throat.

Consult your physician: If your sore throat is caused by Wellbutrin, you may need a dose adjustment. Consult your physician for a proper dose adjustment.

How to ensure safe and effective use of Wellbutrin?

Ensuring the safe and effective use of Wellbutrin involves the following measures:

  • Adherence: Taking your medication regularly is very important. Do not miss the dose or discontinue your medicine because you are experiencing a side effect without a physician’s guidance.
  • Be patient: Wellbutrin takes several weeks to show its therapeutic effect; do not discontinue your medication because you don’t see any changes in your symptoms.
  • Seek help: Inform your healthcare professional about your concerns and the side effects you are experiencing. Your physician will help you get the proper treatment.
  • Regular check-ins: Attend regular follow-up appointments with your healthcare provider to discuss your progress, side effects and any adjustments needed in your treatment plan.
  • Right dose, right time: make sure you take your drugs at the right time and the right dose.


In conclusion, sore throat can be an initial side effect of Wellbutrin; it is often temporary and can be effectively managed. This side effect varies from person to person. Monitor your symptoms, and discuss any concerns with your healthcare provider for proper guidance. It is very important to adhere to your medication to avoid withdrawal symptoms.

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Huecker MR, Smiley A, Saadabadi A. Bupropion. [Updated 2023 Apr 9]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2023 Jan-. Available from:


Bhat V, Kennedy SH. Recognition and management of antidepressant discontinuation syndrome. Journal of Psychiatry and Neuroscience. 2017 Jul 1;42(4):E7-8. Available from:

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