Does Celexa cause bleeding? (3+ factors)

In this article, we will discuss whether Celexa causes bleeding. We will also discuss some research studies and factors influencing bleeding while taking Celexa.

Does Celexa cause bleeding?

Celexa (Citalopram) may cause bleeding as a rare side effect. Like many medications, it can have various side effects and some individuals may experience unusual bleeding or bruising while taking Celexa.

Celexa, a selective serotonin reuptake inhibitor, is an antidepressant used to treat mental health conditions like depression and anxiety (1).

Celexa causes bleeding rarely by affecting platelet function or interacting with other medications. 

If you notice any unexpected bleeding, bruising or other unusual bleeding-related symptoms while taking Celexa, inform your healthcare provider promptly.

What does research suggest?

In a research study, selective serotonin reuptake inhibitors (SSRIs), like Celexa, have been linked to an increased risk of bleeding. This might happen because these drugs can affect how platelets work in the blood (2).

The study shared a case of a 32-year-old woman who experienced severe bleeding due to a condition called drug-induced immune thrombocytopenia while taking Celexa. After stopping the medication and receiving treatment with platelet transfusions and Prednisolone, the patient fully recovered (2).

This case suggests that drug-induced immune thrombocytopenia could be another reason for bleeding in people taking SSRIs.

Another research study suggested that antidepressants that affect the serotonin reuptake mechanism can raise the likelihood of upper gastrointestinal tract bleeding. This risk becomes more significant when these medications are used alongside non-steroidal anti-inflammatory drugs. This study also indicated that acid-suppressing medications can help reduce this elevated risk (3)

Factors increasing the risk of bleeding while taking Celexa

Several factors can increase the risk of bleeding while taking Celexa. It is important to be aware of these factors and discuss them with your healthcare provider if you are prescribed this medication. Factors contributing to an increased risk of bleeding include:

Dosage: Higher doses of Celexa may increase the risk of bleeding. Your healthcare provider will usually prescribe the lowest effective dose.

Age: Elderly people are more prone to bleeding, so caution is often exercised when prescribing Celexa to this population.

Other medications: Concurrent use of medications that also affect blood clotting, such as non-steroidal anti-inflammatory drugs (NSAIDs), can increase the risk of bleeding (4).

A combination of  SSRIs like Citalopram and Sertraline with blood-thinning medications such as Eliquis and Xarelto increases the risk of bleeding by inhibiting the blood’s ability to clot easily, thereby preventing the formation of blood clots.

Medical conditions: Certain medical conditions such as bleeding disorders, liver disease, kidney disease or a history of stomach ulcers, can increase susceptibility to bleeding while taking Celexa.

Alcohol use: Excessive alcohol consumption increases the risk of bleeding when combined with Celexa.

Bleeding history: It is important to inform about your bleeding history or bruising issues to your healthcare provider, as you may be more susceptible to bleeding while on Celexa.

What to do if Celexa causes bleeding? 

If someone experiences this side effect or any unusual symptoms while taking Celexa, it is essential to consult your healthcare provider.

They can assess the situation and determine if bleeding is related to the medication or any other underlying medical condition. They can make appropriate recommendations including dose adjustment or considering alternative treatments if necessary.

Celexa and bleeding is a complex issue and the appropriate course of action may vary depending on the individual circumstances. Remember that while the risk of bleeding with Celexa is relatively low, taking proactive steps can help further minimise that risk.


In conclusion, Celexa does not cause bleeding as a common side effect, individual responses to medications vary. It is crucial to be aware of unusual bleeding or bruising while taking Celexa and promptly communicate such symptoms to a healthcare provider. By discussing these concerns with a healthcare provider, individuals can ensure their safety and well-being while using Celexa or any other medication.





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