Does Celexa cause bleeding? (3+ factors)
By
Ivan Kahwa
Author bio
Mr Ivan Kahwa is a chemist and phytopharmaceutical scientist with expertise in chemistry, pharmacology, phytochemistry, and Nanobiotechnology. He writes and reviews content on these topics.
Mr Ivan Kahwa’s Highlights:
Guest Researcher at the University of Leipzig, Senior Research Fellow/Scientist, and Lecturer at the Department of Pharmacy, Faculty of Medicine, Mbarara University of Science and Technology.
Professional Experience:
Mr Ivan joined PHARMBIOTRAC as a research fellow/scientist during his master of science tenure. He contributed to the development of most of the phytopharmaceutical products in the project. Furthermore, he participated in carrying out the pharmacological activities of the developed products in laboratory animals such as mice and rats in order to develop proper doses hence leading to pre-clinical studies.
With the above relevant research experience, Ivan started to work with the University of Leipzig on collaborative projects with Mbarara University to develop the chemistry of Ugandan Medicinal plants and their pharmacological activities. This was coupled with several consultative positions by different German NGOs. Mr. Kahwa is also a supporting in the teaching and learning at the Departments of Pharmacy and Pharmaceutical Sciences, Faculty of Medicine, Mbarara University of Science and Technology.
With the increase in antimicrobial resistance globally, Ivan retooled his thinking towards developing new naturally derived antibiotic regimens from Ugandan propolis with the assistance of nanotechnology to improve their delivery to microbial cells. Kahwa has also published over 28 articles in peer-reviewed journals and he is currently reviewing for many journals.
Education:
2023-2027: PhD in Pharmaceutical Sciences (ongoing) with a focus on Pharmaceutical Microbiology and Nanobiology at Mbarara University of Science and Technology.
2022: 2Msc. in Pharmacognosy and Natural Medicine Science at Mbarara University of Science and Technology.
2018: Bachelor of Science (Chemistry) at Mbarara University of Science and Technology.
Publications:
▪ Iqbal, S., Jabeen, F., Kahwa, I., & Omara, T. 2023. Suberosin Alleviates Thiazolidinedione-Induced Cardiomyopathy in Diabetic Rats by Inhibiting Ferroptosis via Modulation of ACSL4-LPCAT3 and PI3K-AKT Signaling Pathways. Cardiovascular Toxicology. https://doi.org/10.1007/s12012-023-09804-7
▪ Gupta, A. K., Yadav, R., Sharma, S., Sawale, J., & Kahwa, I. 2023. Anti-ageing Activity and Antioxidant Activity of Methanol Extracts of Leaves and Flowers of Salvia officinalis and Rosmarinus officinalis. Journal of Young Pharmacists, 15(3), 448–455. https://doi.org/10.5530/jyp.2023.15.60
▪ Tolo, C.U., Kahwa, I., Nuwagira, U., Weisheit, A. and Ikiriza, H., 2023. Medicinal plants used in treatment of various diseases in the Rwenzori Region, Western Uganda. Ethnobotany Research and Applications, 25, pp.1-16.
https://ethnobotanyjournal.org/index.php/era/article/view/4683
▪ Kahwa, I., Ajayi, C.O., Yadav, R., Chauhan, N.S., Shah, K., Abdelgadir, A.A., Shegena, E.A., Daniel, S., Omara, T., Asiimwe, J.B. and Ikiriza, H., 2023. Pharmacognostic and phytochemical studies as an invaluable approach for correct identification of medicinal plants: The case of Artemisia vulgaris L. substituted for Artemisia annua L. in Western Uganda. TMR Integr Med, 7, p.e23004.
https://doi.org/10.53388/TMRIM202307004
▪ Nalimu, F., Oloro, J., Kahwa, I. and Ogwang, P.E., 2021. Review on the phytochemistry and toxicological profiles of Aloe vera and Aloe ferox. Future Journal of Pharmaceutical Sciences, 7, pp.1-21.
https://doi.org/10.1186/s43094-021-00296-2
▪ Elamin, O.H.S., Ali, M.A., Elgezuli, I.A.A., Bashir, M.A. and Kahwa, I., 2021. Diagnosis of pre-and post-treatment of echinococcus granulosus with counter current immune electrophoresis and bacterial co-agglutination. Journal of Microbiology and Infectious Diseases, 11(02), pp.88-94.
https://doi.org/10.5799/jmid.951600
Published book Chapter
▪ Kahwa, I., Ayesiga, I., Nakalema, S., Alinaiswe, R., Mbabazi, R. and Iqbal, S., 2023. Natural products in the management of onchocerciasis. In Natural Products in Vector-Borne Disease Management (pp. 63-80). Academic Press. Book Chapter.
https://doi.org/10.1016/B978-0-323-91942-5.00012-4
Submitted manuscripts Under Review:
▪ Comparison of the Wound Healing Activity of the Leaf and Leaf Ash Extracts of Vernonia amygdalina in Rats. Journal name: Clinical Phytoscience
▪ Ethnobotanical Survey of Medicinal plants used in the management of cancer in Uganda. Journal name: Journal of Herbal Medicine
▪ Ethnobotanical survey and phytochemical screening of medicinal plants used in treatment of epilepsy by PROMETRA-Uganda Traditional Health Practitioners in Mpigi District, Uganda. Journal name: Journal of Ethnopharmacology
Submitted book chapters under review
1.Book title: Algae as a Natural Solution for Water-Food-Energy Nexus, Section 4: Microalgae and cyanobacteria for food applications, Chapter 4.6: Safety, toxicological and allergenic aspects of using algae for food. Authors: Christine Kyarimpa, Tom Omute, Caroline K. Nakiguli, Alice V. Khanakwa4, Christopher Angiro, Ivan Kahwa, Fortunate Ahumuza, Timothy Omara*. Publisher: Springer Nature Singapore Pte Ltd. 152 Beach Road, #21-01/04 Gateway East, Singapore 189721, Singapore.
2.Book title: Nutraceuticals Inspiring the Contemporary Therapy for Lifestyle Diseases. Chapter: Nutraceutical applications of Seaweeds and their Phytocompounds in Nutrition and Treatment of Diseases. Authors: Ivan Kahwa, Timothy Omara , Innocent Ayesiga , Gael Noel Neh Neba Ambe , Zehbanaz Javidbhai Panwala , Rachel Mbabazi , Shabnoor Iqbal , Christine Kyarimpa , Christine Betty Nagawa , Kamal Shah ,Nagendra Singh Chauhan* Publisher: CRC Press
You can view my works on the following professional sites:
Research Gate: https://www.researchgate.net/profile/Ivan-Kahwa
Google Scholar: https://scholar.google.com/citations?user=tOwrvqoAAAAJ&hl=en
ORCID: https://orcid.org/0000-0002-6440-3437
Linkedin: https://de.linkedin.com/in/ivan-kahwa-865450159
In this article, we will discuss whether Celexa causes bleeding. We will also discuss some research studies and factors influencing bleeding while taking Celexa.
Does Celexa cause bleeding?
Celexa (Citalopram) may cause bleeding as a rare side effect. Like many medications, it can have various side effects and some individuals may experience unusual bleeding or bruising while taking Celexa.
Celexa, a selective serotonin reuptake inhibitor, is an antidepressant used to treat mental health conditions like depression and anxiety (1).
Celexa causes bleeding rarely by affecting platelet function or interacting with other medications.
If you notice any unexpected bleeding, bruising or other unusual bleeding-related symptoms while taking Celexa, inform your healthcare provider promptly.
What does research suggest?
In a research study, selective serotonin reuptake inhibitors (SSRIs), like Celexa, have been linked to an increased risk of bleeding. This might happen because these drugs can affect how platelets work in the blood (2).
The study shared a case of a 32-year-old woman who experienced severe bleeding due to a condition called drug-induced immune thrombocytopenia while taking Celexa. After stopping the medication and receiving treatment with platelet transfusions and Prednisolone, the patient fully recovered (2).
This case suggests that drug-induced immune thrombocytopenia could be another reason for bleeding in people taking SSRIs.
Another research study suggested that antidepressants that affect the serotonin reuptake mechanism can raise the likelihood of upper gastrointestinal tract bleeding. This risk becomes more significant when these medications are used alongside non-steroidal anti-inflammatory drugs. This study also indicated that acid-suppressing medications can help reduce this elevated risk (3)
Factors increasing the risk of bleeding while taking Celexa
Several factors can increase the risk of bleeding while taking Celexa. It is important to be aware of these factors and discuss them with your healthcare provider if you are prescribed this medication. Factors contributing to an increased risk of bleeding include:
Dosage: Higher doses of Celexa may increase the risk of bleeding. Your healthcare provider will usually prescribe the lowest effective dose.
Age: Elderly people are more prone to bleeding, so caution is often exercised when prescribing Celexa to this population.
Other medications: Concurrent use of medications that also affect blood clotting, such as non-steroidal anti-inflammatory drugs (NSAIDs), can increase the risk of bleeding (4).
A combination of SSRIs like Citalopram and Sertraline with blood-thinning medications such as Eliquis and Xarelto increases the risk of bleeding by inhibiting the blood’s ability to clot easily, thereby preventing the formation of blood clots.
Medical conditions: Certain medical conditions such as bleeding disorders, liver disease, kidney disease or a history of stomach ulcers, can increase susceptibility to bleeding while taking Celexa.
Alcohol use: Excessive alcohol consumption increases the risk of bleeding when combined with Celexa.
Bleeding history: It is important to inform about your bleeding history or bruising issues to your healthcare provider, as you may be more susceptible to bleeding while on Celexa.
What to do if Celexa causes bleeding?
If someone experiences this side effect or any unusual symptoms while taking Celexa, it is essential to consult your healthcare provider.
They can assess the situation and determine if bleeding is related to the medication or any other underlying medical condition. They can make appropriate recommendations including dose adjustment or considering alternative treatments if necessary.
Celexa and bleeding is a complex issue and the appropriate course of action may vary depending on the individual circumstances. Remember that while the risk of bleeding with Celexa is relatively low, taking proactive steps can help further minimise that risk.
Conclusion
In conclusion, Celexa does not cause bleeding as a common side effect, individual responses to medications vary. It is crucial to be aware of unusual bleeding or bruising while taking Celexa and promptly communicate such symptoms to a healthcare provider. By discussing these concerns with a healthcare provider, individuals can ensure their safety and well-being while using Celexa or any other medication.
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References
2.-
Andersohn F, Konzen C, Bronder E, Klimpel A, Garbe E. Citalopram-induced bleeding due to severe thrombocytopenia. Psychosomatics. 2009 May-Jun;50(3):297-8. doi: 10.1176/appi.psy.50.3.297. PMID: 19567773.https://pubmed.ncbi.nlm.nih.gov/19567773/
3.-
de Abajo FJ, García-Rodríguez LA. Risk of upper gastrointestinal tract bleeding associated with selective serotonin reuptake inhibitors and venlafaxine therapy: interaction with nonsteroidal anti-inflammatory drugs and effect of acid-suppressing agents. Arch Gen Psychiatry. 2008 Jul;65(7):795-803. doi: 10.1001/archpsyc.65.7.795. PMID: 18606952.https://pubmed.ncbi.nlm.nih.gov/18606952/
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