Can you take Zoloft and Eliquis together? 

In the article Can you take Zoloft and Eliquis together?, some critical aspects of the drug interaction between Zoloft and Eliquis will be presented.

Some serious health problems can occur from this interaction, so the text warns of possible effects and what should be done if you have any symptoms. 

Can you take Zoloft and Eliquis together? 

No, you can not take Zoloft and Eliquis together unless prescribed by your healthcare provider. . 

Zoloft and Eliquis don’t generally make a good pair because of potential health risks. Make sure you talk to your doctor before you pair these two or any medications together. 

What are the dangers associated with taking Zoloft and Eliquis together? 

The danger of taking Zoloft and Eliquis is the increased risk of bleeding. So, Zoloft and Eliquis should not be used unless absolutely necessary (1).

These drugs are well tolerated when used alone, but they both are associated with some side effects that may hit you severely if you use the two together (1). 

Eliquis is a blood thinner intended to be used for its anticoagulation effects (2). Zoloft is a selective serotonin reuptake inhibitor – which is an antidepressant (3). Although Zoloft’s primary effect is antidepressant, it can still cause blood thinning (3-5).

In fact, Zoloft is contraindicated in people with a bleeding disorder and is not generally paired with any other medication that may prolong bleeding time or increase the risk of GI bleeding, bleeding gums, etc (5). 

This is the reason why the concomitant use of Zoloft and Eliquis is a tricky one – as it can put you at a high risk of excessive bleeding, which could lead to life-threatening complications in some people (1). 

Zoloft and Eliquis are not generally recommended and should only be done if your doctor thinks it has more benefits than risks in your case. Eliquis is contraindicated with other antidepressants as well, like Lexapro, Prozac, Effexor, etc (2). 

Furthermore, Sertraline and other antidepressants should not be taken with other blood thinners, like Xarelto, Warfarin, non-steroidal anti-inflammatory drugs (Aspirin, Meloxicam, etc), etc.

What to do if you are bleeding while using Zoloft and Eliquis?

If you experience bleeding while using Zoloft and Eliquis, you should speak to your doctor. The doctor will likely adjust the dose of medication or, depending on the severity may switch medications (6).

What to do if you have accidentally taken Zoloft and Eliquis together? 

If you have accidentally taken the standard doses of Zoloft and Eliquis once, you should contact your doctor. 

All individuals are different, and they respond differently to medications. Two incompatible meds do much more harm when they’re consistently used together than one-time accidental use. 

However, the use of Zoloft and Eliquis can trigger internal bleeding. Make sure you should call your local emergency helpline.

What are the safer alternatives to Eliquis when taking Zoloft?

The safe option for taking Eliquis and Zoloft is to monitor the patient for bleeding risk.

Several studies have shown that no antidepressant is entirely safe when interacting with an anticoagulant. Therefore, the best option is to assess the risk-benefit and monitor the patient (7-10).


The text Can you take Zoloft and Eliquis together? describes health problems from the interaction between Zoloft and Eliquis medications.

This interaction can lead to bleeding requiring interruption of medications. The text addresses questions such as: What are the dangers of taking Zoloft and Eliquis together? and What should I do if I have a bleed while using Zoloft and Eliquis? to guide the patient on how to proceed in case of experiencing this adverse effect.

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