Can you take Lexapro and Eliquis together?

Can you take Lexapro and Eliquis together?

Lexapro and Eliquis can interact with one another when taken together and the two can only be used if prescribed by the healthcare provider. Eliquis is an anticoagulant, which means it increases the clotting time and the bleeding stops slowly. 

This anticoagulant effect is necessary for a lot of health conditions, but Eliquis can cause significant damage if it is paired with another medication that can increase the risk of bleeding as a side effect. Sadly, Lexapro is included in those meds. In fact, all SSRIs are. 

This is why these two meds should not be used concomitantly. If your healthcare provider believes that you can benefit from this combination, he/she will most likely adjust the dose, suggest taking them at different times, and advise close monitoring. 

It is not recommended to take any medication without your doctor’s approval. 

Potential health risks of taking Lexapro and Eliquis together 

As we have just discussed, Eliquis is an anticoagulant and Lexapro prolongs bleeding time as a side effect. When they both are in your body at the same time, the effects could be life-threatening for some individuals (1,2). 

Although this side effect of Lexapro is not common in every individual, it’s still a big risk to take. Any underlying health conditions can make this combination worse, like gastrointestinal diseases – such as ulcers, which can increase the risk of gastrointestinal bleeding.

This is why you shouldn’t pair Eliquis with antidepressants like Lexapro, Zoloft, Prozac, etc – or pair it with any other prescription medication without consulting your doctor first.

Pharmacist’s advice 

It’s best to not take Lexapro and Eliquis together on your own. If your condition demands it, your doctor will guide you accordingly and will monitor your symptoms frequently. 

If you feel unusual after a day or two of taking these two, even after dose reduction and necessary precautions, immediately report to your healthcare provider. This combination is not a good one for every individual and only a few people can benefit from it. 

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MedlinePlus. Escitalopram: MedlinePlus drug information [Internet]. Bethesda (MD): National Library of Medicine (US); [updated 2022 Feb 15; cited 2022 Dec 16]. Available from:


MedlinePlus. Apixaban: MedlinePlus drug information [Internet]. Bethesda (MD): National Library of Medicine (US); [updated 2022 Feb 15; cited 2022 Dec 16]. Available from:

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