Can Hydroxyzine cause high blood pressure? 

Can Hydroxyzine cause high blood pressure? 

Hydroxyzine may cause high blood pressure if high doses of this antihistamine are consumed. Typically, Hydroxyzine is associated with low blood pressure as a side effect. This is because Hydroxyzine has anti-anxiety effects and it relaxes your nerves and slows down some of the basic physiological functions in your body (1,2). 

This can result in a low heartbeat and blood pressure. Although high blood pressure is not a concern, Hydroxyzine can increase your heartbeat or may cause arrhythmia. 

Some people who are allergic to the medication may suffer from a sudden rise in blood pressure, but such cases are rare and people allergic to Hydroxyzine don’t continue to use this medication. 

If you’re on Hydroxyzine and you’re concerned about your blood pressure, talk to your healthcare provider. If the drug does increase your BP, your doctor may either try to reduce your dose or switch you to another medication. 

What side effects are common with Hydroxyzine?

Hydroxyzine may not increase blood pressure, but it is associated with some side effects. These include (3): 

Common side effects include:

  • Drowsiness or sedation
  • Dry mouth
  • Dizziness
  • Blurred vision
  • Headache
  • Nausea or upset stomach
  • Constipation
  • Confusion or disorientation (especially in older adults)

Rare but serious side effects (contact your healthcare provider if experienced):

  • Irregular or rapid heartbeat
  • Difficulty urinating or urinary retention
  • Tremors or involuntary muscle movements
  • Seizures
  • Severe allergic reactions (e.g., rash, itching, swelling, severe dizziness, difficulty breathing)

It is important to note that misusing or overdosing on Hydroxyzine can affect your heart rate or blood pressure. If you haven’t overdosed on the medication and you still feel your heart racing, you could be allergic to the medication. 

In such cases, you should look for other signs of an allergic reaction and should immediately seek medical attention.

Final words

To sum up, Hydroxyzine does not commonly cause an increase in blood pressure and this side effect was not reported in the clinical trials. However, people are different and can respond differently to medications.

It is also important to note that there could be other factors contributing to high blood pressure and Hydroxyzine might not be the real culprit. Just make sure you discuss your symptoms with your doctor and follow their directions closely. 

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Guaiana G, Barbui C, Cipriani A. Hydroxyzine for generalised anxiety disorder. Cochrane Database Syst Rev. 2010 Dec 8;(12):CD006815. doi: 10.1002/14651858.CD006815.pub2. PMID: 21154375.


Ferreri M, Hantouche EG, Billardon M. Intérêt de l’hydroxyzine dans le trouble anxiété généralisée: étude contrôlée en double aveugle versus placebo [Value of hydroxyzine in generalized anxiety disorder: controlled double-blind study versus placebo]. Encephale. 1994 Nov-Dec;20(6):785-91. French. PMID: 7875114.


LiverTox: Clinical and Research Information on Drug-Induced Liver Injury [Internet]. Bethesda (MD): National Institute of Diabetes and Digestive and Kidney Diseases; 2012–. Hydroxyzine. 2017 Jan 16. PMID: 31643458.