What are the side effects of overdosing on Hydroxyzine? 

By Dr Drielli Vital-Fujii (PhD)
Page last updated: 23/01/2024 | Next review date: 23/01/2026
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Author bio

Dr Drielli Vital-Fujii, PhD, is a Pharmacist with expertise in Drug Design and Development, Enzymes, Molecular Modelling, and Photodynamic Therapy. She writes and reviews content on these topics. 

 

Dr Drielli Vital-Fujii’s Highlights:

 

  • Postdoctoral fellow at the Department of Biochemistry at the University of São Paulo, emphasizing therapy of neglected diseases using light.

 

  • PhD in Pharmaceutical Sciences focusing on drug design and development at the Faculty of Pharmaceutical Sciences of the University of São Paulo.

 

  • Six months as an international researcher at the Center for Discovery and Innovation in Parasitic Diseases (University of California San Diego)

 

  • Master’s degree in Pharmaceutical Sciences focusing on drug design and development at the Faculty of Pharmaceutical Sciences of the University of São Paulo.

 

  • Bachelor of Pharmacy at the University of Mogi das Cruzes – São Paulo / Brazil

 

Professional Experience:

 

2012 – 2018 Project manager at University of São Paulo – Pharmacy Department

Dr Drielli Vital-Fujii has worked with computational studies, synthesis, biological evaluation, design, and development of new inhibitor candidates for Chagas Disease and Leishmaniasis.

 

2017 – 2017 International research fellow at University of California San Diego Skaggs School of Pharmacy and Pharmaceutical Sciences – Center for Discovery and Innovation in Parasitic Diseases.

 

She used Virtual Screening (VS) and High-Throughput Screening (HTS) Integration in the Discovery of new drugs against neglected tropical diseases (NTDs).

 

2018 – 2019 Faculdades Oswaldo Cruz

Dr Drielli Vital-Fujii was a professor in the Faculty of Pharmacy, teaching the subjects of Pharmaceutical Chemistry and Drug Development.

 

2019 – 2021 Researcher in Biochemistry University of São Paulo – Biochemistry Department

 

She applied Photodynamic Therapy in Leishmaniasis Treatment, mentored undergraduate students in scientific activities, and wrote, executed, translated, and reported scientific projects with funding agencies.

 

2023-2023 UniPiaget – University Center.

 

Dr Drielli Vital-Fujii was a Biology, Nutrition, Physiotherapy, and Pharmacy professor.

 

Education:

 

2018 -2021 Postdoctoral at the Department of Biochemistry at the University of São Paulo

 

2013 -2018 PhD of Science: Drugs and Medicines at Department of Pharmacy at University of São Paulo

 

2012 -2013 M.Sc. of Sciences: Drugs and Medicines at the Department of Pharmacy at the University of São Paulo

 

2005-2008 Bachelor of Pharmacy at the University of Mogi das Cruzes

 

The leading publications of Dr Drielli Vital-Fujii are:

 

Vital-Fujii, D.G, Baptista, M.S. (2021). Progress in the photodynamic therapy treatment of Leishmaniasis. Brazilian Journal of Medical and Biological Research, 54, 1-11.

Gatti, F. M., Gomes, R.A., da Fonseca, A.L., Lima, E.J.C., Vital-Fujii, D.G., Taranto, A.G., Varotti, F.P., Trossini, G.H.G. (2020). Antiplasmodial activity of sulfonylhydrazones: in vitro and in silico approaches. Future medicinal chemistry, 13, 233-250.

Silva, E.J., Bezerra-Souza, A., Passero, L.F., Laurenti, M.D., Ferreira, G.M., Fujii, D.G.V., et al. (2018). Synthesis, leishmanicidal activity, structural descriptors and structure-activity relationship of quinoline derivatives. Future medicinal chemistry, 10, 2069-2085.

Leite, F.H.A., Froes, T.Q., da Silva, S.G., de Souza, E.I.M., Vital-Fuji,i D.G., Trossini, G.H.G., et al. (2017). An integrated approach towards the discovery of novel non-nucleoside Leishmania major pteridine reductase 1 inhibitors. European Journal of Medicinal Chemistry, 132, 322-332.

Vital, D.G., Damasceno, F.S., Rapado, L.N., Silber, A.M., Vilella, F.S., Ferreira, R.S., et al. (2017). Application of bioisosterism in design of the semicarbazone derivatives as cruzain inhibitors: a theoretical and experimental study. Journal of Biomolecular Structure and Dynamics, 35, 1244–1259.

Mello, J. F.R., Gomes, R.A., Vital-Fujii, D.G., Ferreira, G.M., Trossini, G.H.G. (2017). Fragment-based drug discovery as alternative strategy to the drug development for neglected diseases. Chemical Biology & Drug Design, 90, 1067-1078.

Pantaleao, S.Q., Fujii, D.G.V., Maltarollo, V.G., da C. Silva, D., Trossini, G.H.G., Weber, K.C., et al. (2017). The Role of QSAR and Virtual Screening Studies in Type 2 Diabetes Drug Discovery. Medicinal Chemistry, 13, 706-720.

Vital, D., Arribas, M., Trossini, G. (2014). Molecular Modeling and Docking Application to Evaluate Cruzain Inhibitory Activity by Chalcones and Hydrazides. Letters in Drug Design and Discovery, 11, 249-255.

Blau, L., Menegon, R.F., Trossini, G.H.G., Molino, J.V.D., Vital, D.G., Cicarelli, R.M.B., et al. (2013). Design, synthesis and biological evaluation of new aryl thiosemicarbazone as antichagasic candidates. European Journal of Medicinal Chemistry, 67, 142-151.

​​You can view some of Dr Drielli’s work below and links to her professional profile.

Orcid: https://orcid.org/0000-0001-9270-0466 

Research Gate: https://www.researchgate.net/profile/Drielli-Gomes-Vital-Fujii 

 

Scopus: https://www.scopus.com/authid/detail.uri?authorId=55829534000

 

Google Scholar: https://scholar.google.com/citations?user=F9U50AEAAAAJ&hl=pt-BR 

 

Linkedin: linkedin.com/in/driellivital

Escavador: https://www.escavador.com/sobre/6101380/drielli-gomes-vital

CDIPD: https://cdipd.org/index.php/about-us/visiting-scientists


Dr Drielli Vital-Fujii (PhD)
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What are the side effects of overdosing on Hydroxyzine? 

The side effects of overdosing on Hydroxyzine are:

Mild side effects

Severe side effects:

  • Mania
  • Psychosis 
  • Agitation 
  • Hallucinations 
  • Convulsions 
  • Arrhythmia 
  • Bradycardia 
  • Rhabdomyolysis 
  • Kidney failure 
  • Coma

These side effects can vary from person to person and depend on how much of the medication is taken. 

Taking a dose or two extra of Hydroxyzine is not likely to cause any significant or life-threatening complications, and the most commonly expected side effect is sedation (1). 

However, if a dangerously high amount of Hydroxyzine is taken, it could lead to complications. The symptoms associated with Hydroxyzine overdose depend on a lot of other factors, like age, genes, underlying disease, basic tolerance, etc. 

Some people who are sensitive to meds or people with renal or hepatic insufficiency are more susceptible to these side effects. 

What to do if you have overdosed on Hydroxyzine? 

If you have overdosed on Hydroxyzine and you feel unusual, immediately call your local emergency helpline. 

Although a slight overdose will not make you feel unusual enough to seek a medical emergency, some people may get severely affected. It’s best to reach out to the hospital as soon as possible. People are different and they can respond differently to this situation. 

This is why you need to make sure that you don’t take more than the recommended dose. It is also important to make sure that you are not consuming expired Hydroxyzine.

Some people may take twice the typical dose thinking that expired medications may become less effective and that double-dosing is important for the desired therapeutic outcome. This is an unsafe practice which can also lead to overdosing.

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References

1.-

MedlinePlus. Hydroxyzine. MedlinePlus drug information [Internet]. Bethesda (MD): National Library of Medicine (US); [updated 2022 Feb 15; cited 2022 Dec 01]. Available from: https://medlineplus.gov/druginfo/meds/a682866.html