Is Synthroid a steroid? (3+ differences)
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Ask Your Pharm
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In this article, we will answer the question, “Is Synthroid a steroid?”. We will discuss whether Synthroid has a steroid in its chemical structure, or if Synthroid is related to steroids in any way and some basic differences between the two.
Is Synthroid a steroid?
No, Synthroid is not a steroid. It does not have the steroid nucleus in its structure and does not relate to steroids. Steroids are different from Synthroid and have steroid in their chemical structure. Both medications are used for separate indications but may also be used as a combination if the concurrent use of both drugs benefits the situation.
Synthroid (also known as Levothyroxine), belongs to a class of medications called hormones and is approved by the FDA for the treatment of hypothyroidism and pituitary thyrotropin suppression (1,2).
Synthroid contains Levothyroxine which is the synthetic version of the body’s natural thyroid hormone. So, Synthroid mimics the effects of natural thyroxine (2).
Steroids are also called corticosteroids and are used in many medical conditions. Steroids have wide usage and endocrine and nonendocrine indications (3).
Steroids work through many different pathways to exert a wide range of effects. Some of the effects caused by steroids include anti-inflammatory, immunosuppressive, metabolic, electrolyte, blood cell and central nervous system effects (3).
What are the key differences between Synthroid and steroids?
There are some major differences between Synthroid and steroids. Some of them are as follows:
| Differentiating characteristics | Synthroid | Steroids |
| Chemical structure | Synthetic form of thyroxine (T4), containing two benzene rings. | Medications containing the steroid nucleus. |
| Mechanism of action | Bind to thyroid receptor proteins and mimic the effects of natural thyroxine. | Multiple pathways with genomic and non-genomic mechanisms of action. Steroids use the glucocorticoid receptor and interactions between the intracellular or a membrane-bound glucocorticoid receptor |
| Medical uses |
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| Side effects |
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| Safety profiles | Generally safe to use, rarely toxicity reported. | Safe to use but long-term use has been associated with toxicity. |
| Legal status | Requires prescription | Also requires a prescription for some types of steroids, while some creams or sprays are available over-the-counter (OTC). |
| Types | There is no type. Synthroid contains one medication i.e. levothyroxine. |
Steroids have types:
|
Why is there a misconception that Synthroid is a steroid?
Some individuals may confuse Synthroid with steroids. The confusion among individuals, regarding the nature of Synthroid is due to the similarity in their names.
Synthroid may have a similar-sounding name to steroids, but it is a different medication with many differences. Synthroid should not be confused with any type of steroid. It should be used on prescription and should not be crushed.
What steps should be followed while taking Synthroid or steroids?
The following things should be kept in mind while taking Synthroid or any steroidal formulation:
Consistency: Be consistent in taking your medications. Do not switch the times of taking the medications.
Dose: Take the medications in the prescribed dosage and do not try to overdose or take a double dose of Synthroid or any steroid.
Record symptoms: Record any uncomfortable side effects that you experience, to help your doctor diagnose the causative agent.
Follow-ups: Do not miss any follow-up appointments. Also, communicate any problems that you might be experiencing while taking the medications, to your healthcare provider.
Interactions: When you are prescribed Synthroid or any steroids, you should inform your doctor about any medications you are taking to avoid drug interactions. Limiting alcohol and caffeine can also help reduce interactions.
Storage: Storage of Synthroid and steroids is important. You should discard expired medications to avoid potential side effects.
Consultations: If you have any concerns regarding your medications, you should consult your healthcare provider.
Synthroid and steroids: Not the same
To the best of my knowledge and according to research, Synthroid is not a steroid and should not be confused as one. Keep in mind that Synthroid and steroids are two different medications, which are prescribed for different indications and have different structures and mechanisms of action.
You may be prescribed both Synthroid and steroids in combination for the treatment of hypothyroidism if your condition benefits from the combination. However, both medications are advised to be taken only on the recommendation of a healthcare professional.
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References
1.-
The Food and Drug Administration (FDA). HIGHLIGHTS OF PRESCRIBING INFORMATION. SYNTHROID® (levothyroxine sodium) tablets, for oral use. Available from: https://www.accessdata.fda.gov/drugsatfda_docs/label/2017/021402s024s028lbl.pdf
2.-
Eghtedari B, Correa R. Levothyroxine. [Updated 2023 Aug 28]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2023 Jan-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK539808/
3.-
Hodgens A, Sharman T. Corticosteroids. [Updated 2023 May 1]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2023 Jan-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK554612/
