Is Seroxat good for you? (+3 uses)

This article will discuss if taking Seroxat at the prescribed dose is good for you. It will also discuss some of the side effects you might experience while taking Seroxat.

Is Seroxat good for you?

Yes, Seroxat is good for you if you suffer from anxiety disorder. However, the effectiveness varies from one person to another. Various factors can affect the treatment outcome, including your medical condition, and use of other prescribed medicine.

Seroxat is a brand name for the popular antidepressant paroxetine. The medicine is prescribed for all types of anxiety disorders. Overdosing or combining Seroxat with other medications can result in serotonin syndrome.

Too much serotonin in the brain can cause agitation, irregular heartbeat, increased anxiety, seizures, and unconsciousness. Hence, Seroxat should always be taken at a dose that is prescribed by your doctor.

What is the success rate of Seroxat?

A research study suggests that depression and anxiety symptoms were reduced in the first week of Seroxat therapy in 211 patients. Response and remission rates after six weeks of therapy were 52.8% and 29.6% for Seroxat IR, 58.9% and 34.4% for Seroxat CR, and 41.5% and 20.5% for placebo, respectively.

Response and remission rates after twelve weeks were 72.9% and 52.5% for Seroxat IR, 73.7% and 56.2% for Seroxat CR, and 61.2% and 44.0% for placebo, respectively (1).

Another report concluded that significantly more patients in the Seroxat group discontinued their therapy due to side effects or suicidal thoughts as compared to the placebo group (2).

What are the benefits of Seroxat?

Seroxat can be used for the following conditions (3):

  • Obsessive-compulsive disorder: repetitive, and uncontrollable behaviour,
  • Social anxiety disorder: fear or avoidance of social gatherings,
  • Post-traumatic stress disorder: depression caused by a traumatic event,
  • Generalized anxiety disorder: feeling anxious and nervous all the time.

What are the other therapeutic effects of Seroxat?

Seroxat also has some off-label use, including:

  • Premenstrual syndrome,
  • Irritable bowel syndrome,
  • Neuropathic pain,
  • Premature ejaculation, and
  • Bipolar depression.

What is the recommended dose of Seroxat?

Disease Initial dose Maximum dose
Obsessive-compulsive disorder 20 mg/day 60 mg/day
Social anxiety disorder 20 mg/day 60 mg/day
Post-traumatic disorder 20 mg/day 50 mg/day
Generalized anxiety disorder 20 mg/day 50 mg/day

What are the problems with Seroxat?

  • Suicidal thoughts: When patients under the age of 18 take Seroxat, they are more likely to experience side effects such as suicide attempts, hostility, and suicidal ideation.
  • Worsening of depression and anxiety: The patient might feel more depressed while taking Seroxat for the first few weeks.
  • Side effects: Some Seroxat users experience akathisia, which causes them to feel restless and unable to sit or stand. Other patients develop serotonin syndrome or neuroleptic malignant syndrome.

What does Seroxat do to the brain?

The major target of Seroxat is the SERT (serotonin transporter), which is a type of monoamine transporter that controls the transportation of serotonin from the synaptic cleft back to the presynaptic neuron (4).

In larger doses (40 mg/day or more), it has been reported that Seroxat functions as a dual serotonin-norepinephrine uptake inhibitor. There is additional evidence that Seroxat can act as an allosteric modulator of SERT (5).

Seroxat is considered to be a strong and selective inhibitor of serotonin uptake while having minimal effect on the other neurotransmitters. Seroxat is most likely to elicit withdrawal symptoms upon discontinuation due to its powerful blockage of serotonin reuptake.

How fast does Seroxat work?

The patient may initially believe that Seroxat is not working for them and making them more tired. However, it may take a week or two after beginning treatment for the effect to become apparent. It might take four to six weeks before the patient feels the full benefit.

The drug should not be discontinued if the patient believes the treatment is not working. Stopping Seroxat abruptly can cause complications, the doctor will most likely advise to gradually reduce the dose.

Why was Seroxat banned?

In 2003, Seroxat was banned in several countries due to the increased risk of suicide in children. The UK Medicines and Healthcare Products Regulatory Agency urged doctors not to give the medication to patients under the age of 18 (6).

In the United States, the active ingredient of Seroxat includes a black box warning due to the possibility of increased suicidal thinking among children.

What are the precautions while taking Seroxat?

  • Do not take Seroxat while pregnant or breastfeeding.
  • Do not drink alcohol when using Seroxat.
  • Do not take Seroxat with antipsychotics, monoamine oxidase inhibitors or St. John’s wort.
  • Long-term use of Seroxat can aggravate diabetes.


I would recommend you to follow the guidelines of your healthcare professional to get the most out your treatment with Seroxat. You should do regular follow-up to keep a close check on the possible side effects or dose adjustments.

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Golden RN, Nemeroff CB, McSorley P, Pitts CD, Dubé EM. Efficacy and tolerability of controlled-release and immediate-release paroxetine in the treatment of depression. Journal of Clinical Psychiatry. 2002 Jul 7;63(7):577-84.


Barbui C, Furukawa TA, Cipriani A. Effectiveness of paroxetine in the treatment of acute major depression in adults: a systematic re-examination of published and unpublished data from randomized trials. Cmaj. 2008 Jan 29;178(3):296-305.


Coleman JA, Gouaux E. Structural basis for recognition of diverse antidepressants by the human serotonin transporter. Nature structural & molecular biology. 2018 Feb;25(2):170-5.


Kowalska M, Nowaczyk J, Fijałkowski Ł, Nowaczyk A. Paroxetine—overview of the molecular mechanisms of action. International Journal of Molecular Sciences. 2021 Feb 7;22(4):1662.


Spurgeon D. GlaxoSmithKline staff told not to publicise ineffectiveness of its drug.,perceived%20increased%20risk%20of%20suicide.

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