Is 3.75 mg of Mirtazapine effective?

In this article, we will discuss the efficacy of 3.75 mg of Mirtazapine. We will also discuss the benefits of a low dose of this antidepressant and what side effects are associated with it. 

Is 3.75 mg of Mirtazapine effective?

3.75 mg of Mirtazapine is effective, but for insomnia – as it is a dose too low for the management of depression. Mirtazapine, although it is primarily approved by the FDA for the management of depression, is used off-label for insomnia because of its sedative properties (1,2).

Generally, 3.75 – 7.5 mg of Mirtazapine can be prescribed to a person for insomnia, especially someone who is new to antidepressants. However, this dose is considered appropriate for depression. 

What are the dosage recommendations for Mirtazapine?

Mirtazapine is available as 7.5, 15, 30, and 45mg tablets. For depression and anxiety, the starting dose of Mirtazapine is 15 mg, as doses lower than that may not help make a proper difference in the symptoms. The dose can be increased to 45 mg in some cases (3). 

For insomnia, 7.5 mg is considered the starting dose. However, some people start from a 3.75 mg dose and then the dose is further increased by the doctor (3). 

Some people may take 15 mg of Mirtazapine for insomnia (3). The dose escalation for insomnia is common as Mirtazapine-induced sedation may start to wear off as the body adjusts to the medication. 

What are the side effects associated with 3.75 mg of Mirtazapine?

3.75 mg is not known to cause any concerning side effects. However, it may cause some common side effects like (4):

These side effects can vary from person to person, as different people can have different factors affecting their health. A small number of people could be allergic to Mirtazapine and may experience allergy symptoms. Such people should immediately seek medical attention.

What to do if 3.75 mg of Mirtazapine does not work for you?

If you find that a low dose like 3.75 mg of Mirtazapine doesn’t seem to be working for you, it’s important to discuss this with your doctor.

Low doses are often used initially to make sure your body doesn’t have any adverse reactions to the medication. Once it’s clear you tolerate the medication well, your doctor may increase the dose to better address your condition.

However, never take more on your own without your doctor’s guidance. Dosage adjustments should always be made under the supervision of your healthcare provider. 

So, have a proper discussion with your doctor about your experience, who can help determine the next steps to manage your condition effectively.

How to ensure the safe and effective use of Mirtazapine?

Follow Your Doctor’s Instructions: Take the medication exactly as prescribed by your healthcare provider. (1,2)

  • Mirtazapine is often taken in the evening before bedtime because it can make you drowsy. Follow your doctor’s guidance on when to take it.
  • Don’t alter your dosage without consulting your doctor. Changes should always be made under medical supervision.
  • It can take a few weeks for Mirtazapine to show its full effects. Keep taking it as directed, even if you don’t notice immediate changes.
  • Limit or avoid alcohol while on Mirtazapine, as it can enhance its side effects.
  • Drink plenty of water to stay hydrated, especially if you experience side effects like dry mouth.
  • If you have concerns or experience side effects, don’t hesitate to discuss them with your healthcare provider. They can adjust your treatment if needed.
  • Keep up with your doctor’s appointments for monitoring and to discuss your progress.

Remember, the safe and effective use of medications is an important key to achieving the best possible therapeutic response.


In this article, we have discussed the safety and efficacy of Mirtazapine. We have also discussed some important tips to ensure the safe and effective use of this antidepressant.


  1. Jilani TN, Gibbons JR, Faizy RM, Saadabadi A. Mirtazapine. 2022 Sep 7. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2023 Jan–. PMID: 30085601. Available from: 
  1. Mirtazapine tablets, USP 7.5 mg, 15 mg, 30 mg and 45 mg. DailyMed [Internet]. Available from: 
  1. The Food and Drug Administration (FDA). HIGHLIGHTS OF PRESCRIBING INFORMATION. Remeron (Mirtazapine) tablets, for oral use. Available from:
  1. National Library of Medicine. Mirtazapine: MedlinePlus Drug Information [Internet]. Bethesda (MD): U.S. National Library of Medicine. Available from: 

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