Does Mirtazapine sedation wear off?

In this article, we will discuss how and when Mirtazapine-induced sedation starts to wear off. We will also discuss the impact of this reduced sedation with time on people who specifically take Mirtazapine as a sleep aid.

Does Mirtazapine sedation wear off?

Yes, Mirtazapine-induced sedation may start to wear off within a few weeks of your treatment with this antidepressant. This diminished sedation can have different effects on people and their treatment goals, as people take Mirtazapine for different reasons. 

Mirtazapine is primarily prescribed for the management and treatment of depression (1,2). However, it is one of the very few antidepressants that can be used for insomnia at low doses – like Trazadone. This makes Mirtazapine popular among people who suffer from depression comorbid with insomnia. 

According to several clinical surveys, Mirtazapine is being used by some people only for its sedative properties at lower doses (3,4). For such people, reduced sedation on this medication as the treatment continues is not ideal. 

However, for people who take Mirtazapine only for depression and they find no trouble sleeping without having the medication in their system, Mirtazapine-induced sedation is just a side effect and they begin to feel better when drowsiness associated with this medication starts to wear off. 

What to do if you take Mirtazapine for sedation and it starts to wear off?

If you’re taking Mirtazapine for its sedative properties and it starts to become ineffective, please reach out to your healthcare provider. It’s not uncommon for the body to adjust to the medication over time, affecting its sedative effects. This situation can affect the treatment goals.

When this happens, it’s essential to talk to your doctor about it. One common approach is to consider increasing the dose, but only up to a safe limit. Going beyond this limit might lead to more side effects without significantly improving the sedative effect, so it’s crucial to find the right balance.

Your doctor will carefully consider the benefits versus the risks and guide you through this process. It’s essential to follow their recommendations and not attempt to adjust the dosage on your own.

In some cases, if increasing the dose doesn’t provide the desired sedation, your doctor might explore alternative medications or strategies to help with sleep. They might suggest combining Mirtazapine with another medication or recommend changes in your sleep routine and habits.

Just make sure you follow your doctor’s advice and do not make any changes to your prescription on your own. 

What to do if Mirtazapine causes sedation as a side effect?

If Mirtazapine causes sedation as a side effect or an undesirable effect, talk to your healthcare provider. It’s common for people to feel sleepy on this antidepressant, but the good news is that it often subsides over time (1). 

It’s essential to be patient during the initial weeks of treatment, as this is when the sedative effect tends to be strongest. To prevent daytime sedation, many people find it helpful to take Mirtazapine at bedtime. 

By doing this, the peak sedative effect occurs during your sleep hours, minimizing its impact on your daytime activities (1). This timing adjustment can make a significant difference in how you feel throughout the day. 

However, it may not always help since Mirtazapine has a half-life of about 20-40 hours, which is the time taken by the drug to reduce its concentration to half (5). 

This is why discussing this with your doctor is important. ne common approach is dose reduction. Lowering the dosage of Mirtazapine can often help lessen the sedative effect while still allowing you to benefit from its antidepressant properties.

It’s crucial not to adjust the dose on your own, as your doctor will carefully guide you through this process to ensure your safety and well-being.

In some cases, if dose reduction doesn’t fully address the issue, your doctor might discuss alternative antidepressant options with fewer sedative effects. Just make sure you trust your doctor with the right choice of antidepressant and do not make any changes in your prescription on your own. 


In this article, we have discussed the decrease in Mirtazapine-induced sedation as the treatment with the antidepressant continues. We have discussed how this reduced sedation can affect some people and their treatment goals, but how it could be a good sign for people who are not looking for this effect. 

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