How to protect your liver while taking Lamisil (Terbinafine)?

In this article, we will discuss the best ways to protect your liver or minimise liver injury while taking Lamisil (Terbinafine), an antifungal medication. We will also discuss the mechanism of liver injury with Lamisil and how it is managed in clinical settings. 

How to protect your liver while taking Lamisil (Terbinafine)?

To ensure the safety of your liver while taking Lamisil (Terbinafine), the following steps are essential:

Talk to your healthcare provider

The first step is to discuss the use of Lamisil with your healthcare provider. Make sure to inform your doctor about any history of liver injury or related conditions before taking Lamisil, especially if you’re at higher risk due to alcohol consumption or pre-existing liver disease (1). 

Your doctor can closely monitor you and adjust the dosage or suggest alternative treatments if necessary, ensuring your safety throughout the course of treatment.

Follow dosage instructions properly

Follow your healthcare provider’s dosage instructions diligently. Avoid self-adjusting the dosage or extending the treatment duration without medical approval, as this can increase the risk of liver-related side effects. 

Sticking to the recommended dose and duration is essential to minimize any potential harm to your liver.

Avoid the use of alcohol

During Lamisil treatment, it’s recommended to avoid alcohol consumption. Alcohol can place extra strain on your liver, making it more susceptible to the medication’s adverse effects. By abstaining from alcohol, you’ll be taking a proactive step to safeguard your liver’s well-being (1).

Closely monitor your side effects

Keep an eye out for any symptoms that might indicate liver problems. If you notice persistent nausea, abdominal pain, jaundice (yellowing of the skin or eyes), or unusual fatigue, contact your doctor immediately (1). 

To monitor your liver’s health during Lamisil treatment, your doctor may recommend regular liver function tests. These tests can detect any potential liver injury at an early stage, allowing for timely intervention if needed. 

Research studies on Lamisil-induced liver injury

Several research studies have indicated that although it is uncommon, the use of Lamisil (Terbinafine) can cause acute liver injury. The risk of liver damage with this antifungal can vary among individuals, as people can have different factors affecting their liver functions (1,2). 

Research indicates that during Terbinafine oral therapy, serum aminotransferase levels may elevate in less than 1% of patients. However, it usually resolves without stopping the treatment. 

Clinically apparent liver injury from Terbinafine is rare (1 in 50,000 to 120,000 prescriptions) and may present within the first 6 weeks of therapy.  Severe hepatocellular injury with acute liver failure has also been reported (1,3). 

Mechanism of liver injury with Lamisil

According to clinical studies, Terbinafine can cause acute liver injury due to a hypersensitivity reaction. Certain genetic factors have been linked to liver injury caused by the drug (1). 

While the exact mechanism is not fully understood, studies have shown these genetic associations in people who experienced liver injury from terbinafine, indicating that the reaction is likely immune-related (1).

How is Lamisil-induced liver injury managed?

If someone experiences liver injury due to Lamisil, it’s important to seek immediate medical attention. Doctors usually advise stopping the use of Lamisil to prevent any further harm to the liver.

The person will be carefully monitored by their healthcare provider, who may conduct liver function tests to assess the severity of the injury and keep track of their recovery progress (4).

Depending on how severe the liver injury is, doctors might suggest additional treatments or interventions to support the liver’s function and help it heal. In more serious cases, hospitalization may be required for close monitoring and specialized care.

During the recovery period, the patient may receive guidance on following a specific diet and lifestyle changes to reduce any extra strain on the liver. This could involve avoiding alcohol and certain medications that could worsen liver function.

In some situations, healthcare providers may prescribe medications or therapies to manage specific symptoms associated with liver injury caused by Lamisil. For instance, if the person experiences nausea, they might be given medications to help alleviate this discomfort.

It’s crucial for individuals to inform their healthcare provider about any pre-existing liver conditions or risk factors before starting Lamisil treatment. 

This information allows the doctor to make informed decisions about whether Lamisil is appropriate for them and to closely monitor those who may be at higher risk for liver injury. 

Remember, open communication with your doctor is vital for your safety and well-being.


In this brief article, we have covered everything about Lamisil-induced liver injury – including its mechanism, symptomatic management, and potential prevention strategies. 

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LiverTox: Clinical and Research Information on Drug-Induced Liver Injury [Internet]. Bethesda (MD): National Institute of Diabetes and Digestive and Kidney Diseases; 2012–. Terbinafine. 2018 Jan 1. PMID: 31643929.


Yan J, Wang X, Chen S. Systematic review of severe acute liver injury caused by terbinafine. Int J Clin Pharm. 2014 Aug;36(4):679-83. doi: 10.1007/s11096-014-9969-y. Epub 2014 Jul 2. PMID: 24986266.


Choudhary NS, Kotecha H, Saraf N, Gautam D, Saigal S. Terbinafine induced liver injury: a case report. J Clin Exp Hepatol. 2014 Sep;4(3):264-5. doi: 10.1016/j.jceh.2014.03.040. Epub 2014 Apr 3. PMID: 25755569; PMCID: PMC4284205.


Lala V, Zubair M, Minter DA. Liver Function Tests. 2023 Apr 7. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2023 Jan–. PMID: 29494096.