How long does Terbinafine stay in your system?

In this brief article, we will discuss the approximate time taken by Terbinafine, an antifungal agent, to leave your system. We will also discuss various factors affecting the stay time or the duration of action of Terbinafine in the body.

How long does Terbinafine stay in your system?

Terbinafine can stay in your system for quite a while, with different parts of your body affecting how long it takes to completely eliminate the drug. The plasma half-life of Terbinafine is around 36 hours, meaning half of the drug is eliminated in that time (1,2). 

The remaining drug further reduces to half of its concentration within the next 36 hours. Typically it takes five half-lives for a drug to completely wash out of your system, which indicates that Terbinafine should be removed within a week from your body. 

However, Terbinafine has a tendency to stay in skin, nails, and adipose (fat) tissues for a longer period of time, making its terminal half-life much longer – up to 200 days. (2)

This is why even after you stop taking Terbinafine, it can still be detected in certain parts of your body for an extended period. It’s important to be aware of this when considering potential interactions with other medications and to follow your doctor’s advice for the safest use of the drug.

What factors can affect the time taken by Terbinafine to leave your body? 

Several factors can influence how long Terbinafine stays in your body before it is completely eliminated. Some of these factors include (1,3):

  • Dosage: The higher the dose of Terbinafine you take, the longer it may take for your body to clear the drug.
  • Duration of use: If you have been taking Terbinafine for a prolonged period, it can take more time for the drug to leave your system completely.
  • Age: Younger individuals may eliminate Terbinafine faster than older adults.
  • Liver function: The liver plays a crucial role in breaking down and eliminating drugs from the body. If you have liver problems, it can slow down the clearance of Terbinafine.
  • Kidney function: Similarly, impaired kidney function may affect how quickly your body can eliminate Terbinafine.
  • Overall health: Your general health condition can impact how your body processes and eliminates the drug.
  • Other medications: Certain medications can interact with Terbinafine, affecting its metabolism and elimination.

It’s important to talk to your healthcare provider about any concerns you may have regarding Terbinafine’s presence in your body and any potential interactions with other medications you might be taking.

It is also important to make sure that you’re Terbinafine in the best possible way while avoiding other medications and excessive consumption of alcohol – that may affect your antifungal treatment or your body’s natural ability to heal. 

When does Terbinafine clearance hold clinical significance?

When it comes to Terbinafine clearance, two critical aspects that hold clinical significance are drug interactions and the duration of treatment.

Some drugs can affect Terbinafine metabolism, leading to altered clearance rates, which may necessitate dosage adjustments or close monitoring.

Additionally, the duration of treatment is essential in fungal infections treated with Terbinafine. Monitoring Terbinafine clearance helps healthcare providers determine the appropriate length of treatment needed for complete recovery (3). 

If the drug stays in the body for an extended period, it can lead to drug accumulation, which may increase the risk of side effects and compromise the overall effectiveness of the treatment. 

On the other hand, if the drug is cleared too quickly, it may not have sufficient time to combat the infection effectively.


In this article, we have discussed Terbinafine clearance and the factors that may affect it. We have also discussed the clinical significance of the time taken by Terbinafine to leave the body and when it can make a difference. 

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