How long does Prednisone stay in your system?

How long does Prednisone stay in your system?

Prednisone stays in your system for about 12 to 20 hours, depending on some factors. Prednisone has a short half-life of about 2-4 hours. After this time period, the concentration of the drug reduces to half in your body (1). 

The remaining concentration of the drug further reduces to half after the next 2-4 hours. The process continues until the drug is completely excreted out of your body. So, it would roughly take 12-20 hours for Prednisone to leave your system completely. 

Prednisolone is a common Corticosteroid which can be used to manage the symptoms associated with a number of health conditions. However, this medication may not suit every other individual. If you fail to notice a good change in your symptoms or experience side effects, please reach out to your doctor.

Factors that can affect the stay time of Prednisone 

There are some factors that may delay the stay time of Prednisone in your body. These are

  • Age
  • Underlying health condition 
  • Concomitant use of other medications


Age is the biggest factor affecting the drug metabolism in your body, be it Prednisone or any other medication. 

Elderly populations usually have compromised organ functions as your organs grow old with you. Such people may take longer to metabolise and remove Prednisone completely. 

Underlying health condition 

Some underlying health conditions can affect the metabolism and excretion of Prednisone. Since the liver is the organ primarily involved in the metabolism of Prednisone and other medications, liver diseases can significantly slow down that process. 

People with hepatic insufficiency can’t metabolise the drug effectively into its inactive metabolites and the active drug remains in their system for a longer period of time. 

Concomitant use of other medications

The concomitant use of other medications can affect the absorption and metabolism of Prednisone. Drug interactions can make your drug more or less absorbed. 

This is why you should always rule out any possible drug-drug interactions before taking two or more medications at the same time. 

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MedlinePlus. Prednisone. MedlinePlus drug information [Internet]. Bethesda (MD): National Library of Medicine (US); [updated 2022 Feb 15; cited 2022 Dec 07]. Available from: