How long after taking Terbinafine can you drink coffee?

This brief article with discuss the concomitant use of Terbinafine and coffee. We will discuss the potential risks of taking the two together and will also talk about the safe ways to consume caffeine while minimising the risk of adverse events. 

How long after taking Terbinafine can you drink coffee?

It is not generally recommended to drink coffee while being treated with oral Terbinafine, an antifungal medication. Terbinafine can affect the liver’s ability to process caffeine – the active ingredient present in coffee (1). 

To ensure the effectiveness and safety of your treatment, it’s best to avoid drinking coffee while you are on Terbinafine. If you have any concerns or questions, it’s always a good idea to talk to your healthcare provider.

What does research suggest?

There is limited research on the effects of Terbinafine on caffeine metabolism. However, some studies do show a link between them. In one research study conducted by Wahllander and Paumgartner, it was observed that Terbinafine led to a 21% reduction in caffeine clearance (2).

In another study, researchers examined how Terbinafine affects the liver’s microsomal system. To do this, they gave a single oral dose of Terbinafine to 8 healthy men and observed how the liver processed caffeine, which works similarly to the drug (3).

The results revealed that Terbinafine had a strong impact on the liver’s ability to break down caffeine. As a result, caffeine stayed in the body for a longer period when Terbinafine was taken (3). 

However, the medication itself remained within the appropriate range in the body, meaning it was still effective at treating infections (3).

This indicates that drinking coffee along with Terbinafine will not affect the potency or efficacy of the antifungal agent, but can prolong the stay time of caffeine in your system, which can increase the risk of caffeine-induced side effects. 

What are the potential side effects of drinking coffee with Terbinafine?

As stated earlier, Terbinafine can prolong caffeine metabolism – which means it remains in your body in an active form for a longer period of time. This can increase the risk of common side effects of caffeine consumption and they may become more pronounced. 

Common side effects associated with caffeine include: (4)

  • Anxiety
  • Restlessness and shakiness
  • Insomnia
  • Headaches
  • Dizziness
  • Fast heart rate
  • Dehydration
  • Frequent urination

These side effects can vary from person to person, and can also depend on the amount of coffee consumed along with Terbinafine. This is why it’s generally recommended by doctors to avoid drinking coffee while taking Terbinafine. 

The drug has a long elimination half-life, which means you will have to wait a long time until the drug has been completely removed from your body (5). However, if you can’t do well without your usual cup of coffee in the morning, please discuss this with your doctor. 

You should also avoid Terbinafine with alcoholic beverages, as this combination can also affect your central nervous system. Alcohol can also slow down your body’s natural ability to heal from an ongoing fungal infection.

What to do if you have accidentally consumed coffee while taking Terbinafine?

Accidental caffeine intake once or twice with Terbinafine is not likely to cause major side effects and you may not need to do anything about it. However, if you feel unusual or if you are experiencing caffeine-induced side effects, please seek medical attention.

Since the antifungal agent slows down the breakdown and removal of caffeine, it may take some time for you to feel better. You can take OTC painkillers, like Tylenol, for headaches. It is also important to drink plenty of water, as caffeine is a mild diuretic and it will keep removing water from your body to some extent (6). 

Again, these side effects will get better as soon as the concentration of caffeine starts to drop down in your body. However, it’s best to seek medical attention if you feel unusually anxious. 

What other drug interactions are common with Terbinafine? 

Terbinafine, as per the FDA guidelines, may also interact with certain medications, including Cimetidine, Fluconazole, Cyclosporine, and Rifampin (1). It’s crucial to be aware of these potential drug interactions to ensure the safe and effective use of Terbinafine.

If you are taking any of these medications or others, it’s essential to discuss them with your healthcare provider before starting Terbinafine treatment.


In this article, we have discussed the potential side effects of drinking coffee with Terbinafine. We have also discussed some options for symptom management and have discussed other medications that should not be taken along with Terbinafine.

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