Does Wellbutrin-induced irritability go away?(+5 tips)

In this brief article, we will discuss one of Wellbutrin’s common side effects, which is irritability. We will also indicate what to do if you experience irritability and tips to manage it while using Wellbutrin.

Does Wellbutrin-induced irritability go away?

Yes, Wellbutrin-induced irritability goes away. Irritability can last for the first few weeks of the treatment. Irritability mostly goes away on its own as the body adjusts to the medication. Individuals may experience restlessness and irritability shortly after starting Wellbutrin.

Wellbutrin is an antidepressant that alters certain neurotransmitter levels in the brain. Wellbutrin enhances mood, energy levels and motivation. However, it can cause side effects such as irritability, aggression, insomnia, nervousness and tremors. (1)

Individual responses vary, and it’s crucial to report any persisting irritability or other side effects to your healthcare providers. They can assess whether to adjust the dosage or to consider alternative treatments to manage irritability effectively.

It’s important to note that you should never make changes to your medication dosages or regimens without consulting your healthcare providers.

What does the research suggest?

Research indicates that irritability is one of the common symptoms of depressed individuals. Wellbutrin and other antidepressants such as selective serotonin reuptake inhibitors (SSRIs) are used to treat irritability and similar depressive symptoms. 

Wellbutrin works by increasing the levels of dopamine and norepinephrine in the brain. These neurotransmitters play a role in mood regulation, motivation and energy levels. Alteration in these neurotransmitters can cause irritability and other potential side effects of Wellbutrin. (2,4)

In a 12-week clinical trial, Wellbutrin was given to 127 patients to treat major depression disorder, dysthymia and other mood disorders. Results showed that irritability was the most common side effect. 9.4% of the patients experienced irritability as an adverse event.(5)

When the medication builds up in your body and the body adjusts to its effects, irritability and other common side effects will most likely go away. 

What to do if Wellbutrin causes irritability?

If you experience irritability as a side effect of Wellbutrin, it’s important to communicate this to your healthcare providers. They can guide you on how to manage this side effect. This may include the following steps:

• Healthcare provider’s assessment: Your healthcare provider will likely assess the severity of irritability and your overall situation.

• Dosage adjustment: Adjusting the dosage of Wellbutrin may help alleviate irritability. This should be done under the guidance of your healthcare provider.

• Change the timing of medication: Your healthcare provider may suggest changing the timing of when you take Wellbutrin, as this can alleviate side effects sometimes.

• Consideration of alternatives: In case irritability persists, your doctor might explore alternative medications or treatment options for managing irritability. 

• Lifestyle changes: A healthy lifestyle including regular exercise, getting enough sleep and a balanced diet can enhance your mood and reduce irritability. (3)

What are the alternative antidepressant options available if Wellbutrin causes irritability? 

Your healthcare provider might consider an alternative antidepressant in case Wellbutrin causes irritability. Alternatives may include changing the formulation of Wellbutrin or switching to a different class of antidepressants. Alternative options may include: 

• Wellbutrin extended-release formulation: If irritability is primarily associated with immediate-release Wellbutrin, your healthcare provider might offer the extended-release (XR) formulation, which may have a different impact on side effects.(5)
• Selective serotonin reuptake inhibitors (SSRIs): Prozac, Zoloft and Celexa are known for their impact on serotonin levels. They can have different side effect profiles compared to Wellbutrin.
• Serotonin-norepinephrine reuptake inhibitors (SNRIs): Consider alternatives such as Effexor which affect both serotonin and norepinephrine.
• Tricyclic antidepressants: Older antidepressants like amitriptyline and nortriptyline have different mechanisms of action compared to Welbutrin 

What are other approaches for managing irritability?

Treatment options for managing irritability depend on the underlying cause. Your healthcare provider would recommend the most appropriate intervention based on your specific circumstances. Treatment options may include the following: 

• Cognitive-Behavioral Therapy: It can help individuals identify and address the cause of irritability and teach coping strategies.

• Stress management techniques: Learning and practicing stress-reduction techniques can be effective in managing irritability.

• Parent management training: This therapeutic approach helps parents develop effective strategies for managing their child’s behavior.

• Support groups: Joining support groups to talk about your experience and challenges can provide you with support and a sense of understanding. (2)

In summary, Wellbutrin-induced irritability goes away usually within the first weeks of starting the medication. Irritability is one of the common side effects of Wellbutrin and other antidepressants. However, not everyone experiences the same side effects and responses to the medication vary from one person to another.

In my experience as a pharmacist, it’s important to note that you should never make changes to your medication regimen without consulting your healthcare provider. Communicate with your healthcare provider about all the issues you’re having to find the most appropriate approach to your condition.

References