Does Wellbutrin age you? (3+ tips)

In this article, we will explore whether Wellbutrin affects the ageing process. We will also discuss the possible link between Wellbutrin and ageing, the contributing factors that may influence ageing, and strategies to manage drug-induced ageing.

Does Wellbutrin age you?

No, Wellbutrin does not cause ageing. Wellbutrin, as an NDRI (norepinephrine and dopamine reuptake inhibitor) antidepressant, does not directly influence the ageing process. However, some individual factors may contribute to premature ageing while using Wellbutrin.

Bupropion, the active ingredient in Wellbutrin, affects certain neurotransmitters in the brain, such as norepinephrine and dopamine. Bupropion mainly regulates dopamine, which is involved in pleasure and motivation.

When the drug acts on dopamine and norepinephrine, it can have a stimulating effect, which is beneficial when you have depressive symptoms such as a lack of energy and motivation. The chemical dopamine is strongly associated with pleasure and reward. 

Is there a direct connection between Wellbutrin and the ageing process?

Wellbutrin is not directly linked with the ageing process. Wellbutrin is used to treat depression, and depression itself may impact the ageing process. Depression is associated with various age-related health problems, including cardiovascular disorders, delayed metabolism, and memory issues.

This occurs because depression can alter certain chemicals in the brain. If left untreated, it can damage cells and lead to accelerated ageing (1). According to research studies, patients with major depressive disorder have more health problems as they get older.

This study suggests that the biological changes in major depression are similar to the changes that happen in our bodies as we age and patients with depression are at a higher risk of age-related health issues (2).

Additionally, another clinical study suggests that long-term stress and depression can make you age faster and result in symptoms such as loss of appetite and reduced physical activity. Stress increases the production of harmful substances, which can affect body cells. Prolonged stress may increase the risk of depression and accelerate the ageing process (3).

Wellbutrin is beneficial for elderly people dealing with depression and serious medical conditions. Research indicates that Wellbutrin helps reduce depressive symptoms, even in the initial phase of treatment. Patients taking Wellbutrin also experience fewer depression symptoms such as insomnia and anxiety.

Wellbutrin is generally well-tolerated, with most patients not experiencing serious side effects. Researchers suggest that lower doses of Wellbutrin may be effective for older adults with medical conditions (4). 

Which factors can accelerate ageing while taking Wellbutrin?

The factors which can accelerate ageing while taking Wellbutrin may include:

Biological factors 

Your genetic makeup may determine the rate at which you age. Some people have genetic factors that make them prone to age-related health problems.

Increased exposure to UV radiation, stress, and harmful substances, can lead to cellular damage, contributing to the ageing process. Reduced metabolism and energy levels, stress, depression, and anxiety, contribute significantly to the ageing process (5). 

Lifestyle factors

Smoking, alcohol use, and lack of physical activity may accelerate the ageing process. Additionally, inadequate nutrition, insufficient water intake, excessive sun exposure, and poor lifestyle choices can also contribute to premature ageing (4).

How to manage drug-induced ageing?

The following strategies might help in reducing the drug-induced ageing process:

  • Consult your doctor to minimize the number of medications taken simultaneously, as concomitant drug use can contribute to ageing.
  • Maintain regular checkups and inform your doctor if you experience any side effects from prescribed medications. 
  • Stay hydrated and lead an active lifestyle, including regular exercise. 
  • Avoid smoking and excessive alcohol consumption, as these factors can play a significant role in ageing when combined with medication. 


Wellbutrin, an antidepressant, does not directly cause ageing, as it does not have such properties that speed up the natural ageing process. However, some individual factors, including the presence of depression, can indirectly contribute to signs of ageing.

While Wellbutrin’s pharmacology has no direct link to ageing, it is important to consider individual responses and potential side effects when using this medication.  

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Lorenzo EC, Kuchel GA, Kuo CL, Moffitt TE, Diniz BS. Major depression and the biological hallmarks of aging. Ageing Res Rev. 2023 Jan;83:101805. doi: 10.1016/j.arr.2022.101805. Epub 2022 Nov 21. PMID: 36410621; PMCID: PMC9772222. Available from: 


Xie X, Shen Q, Cao L, Chen Y, Ma L, Xiao Q, Yu C, Fu Z. Depression caused by long-term stress regulates premature aging and is possibly associated with disruption of circadian rhythms in mice. Physiol Behav. 2019 Feb 1;199:100-110. doi: 10.1016/j.physbeh.2018.11.011. Epub 2018 Nov 12. PMID: 30439372. Available from: 


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