Does Wellbutrin 150 work? (+3 Factors)

In this article, we will discuss the working effectiveness of Wellbutrin 150mg, the factors affecting its performance, the common side effects and compare it with other antidepressants like SSRIs.

Does Wellbutrin 150 work? 

Yes, Wellbutrin 150 mg may work for some individuals in treating depression and may also help with smoking cessation. However, its effectiveness varies from person to person, and it may not work for everyone. It’s essential to consult with a healthcare professional for personalized guidance and treatment recommendations.   

What is the intended Purpose of Wellbutrin 150 mg?

Wellbutrin 150 mg is a medication primarily prescribed to treat major depressive disorder (MDD). It is also utilized to aid in smoking cessation by reducing nicotine cravings. The active ingredient in Wellbutrin 150 mg is Burropion which belongs to a class of atypical antidepressants.

The Wellbutrin 150mg dosage is a common starting point for many patients, and healthcare providers may adjust it based on an individual’s response and tolerance. 

What influences Wellbutrin 150 mg’s working? (+3 factors)

The working of Wellbutrin 150mg can be influenced by several factors:


The prescribed dosage can impact its effectiveness. It is generally prescribed at a standard dosage of 150mg per day. Healthcare professionals often start from this dose to assess the response of the patient (1). 

People may respond differently to the same dose due to factors like their body weight, metabolism, and the severity of their condition. Some patients experience significant improvements with a standard 150mg dose, while others may require adjustments.

If the initial dosage proves insufficient in alleviating the symptoms,  the doctors prefer to increase the dose. This can involve taking 300mg per day (2 tablets of 150mg). 

Treatment Duration

Wellbutrin 150mg, like many antidepressant medications, may not provide immediate relief. It typically takes several weeks of consistent use before patients experience the complete benefit of the medication (2).

The duration of treatment can vary depending on individual response and the nature of their condition. In cases of depression, doctors often recommend continuing the medication for several months and sometimes longer to maintain symptom relief and reduce the risk of relapse. 

Co-existing Medical Conditions

Some co-existing medical conditions like seizures, eating disorders, and liver or kidney disease may interact with Wellbutrin 150mg, influencing its effectiveness. 

What are Wellbutrin 150mg common side effects? 

Common side effects of Wellbutrin 150mg may include (3): 

  • Insomnia
  • Heartburn 
  • Dry Mouth
  • Headache
  • Nausea or Vomiting
  • Weight loss
  • Agitation or Restlessness

It is important to know that these symptoms may vary from person to person. Always consult a doctor on managing the side effects of any medicine. 

Who should not take Wellbutrin 150mg?

You shouldn’t use Wellbutrin 150 mg if you have:

How well does Wellbutrin work as compared to other antidepressants?

Wellbutrin 150mg works differently compared to many other antidepressants. It is not an SSRI (Selective Serotonin reuptake inhibitor) like drugs Prozac or Zoloft. Instead wellbutrin 150mg is a norepinephrine-dopamine reuptake inhibitor (NDRI).

The choice between Wellbutrin 150mg and other antidepressants depends upon the patient’s specific needs and the nature of the depression. Wellbutrin 150mg is known for having a unique profile with potential benefits such as reduced risk of weight or sexual side effects, while SSRIs can lead to a range of prolonged side effects like weight gain, sleeplessness, and sexual dysfunctions. 


In this article we have discussed does wellbutrin 150mg works, and the factors affecting its effectiveness. We have also discussed its common side effects and compared it with other antidepressants like SSRIs. Upon discussion, it becomes evident that Wellbutrin 150mg may be more suitable for patients with major symptoms of depression. 



Was this helpful?

Thanks for your feedback!



Acheson A, de Wit H. Bupropion improves attention but does not affect impulsive behavior in healthy young adults. Experimental and clinical psychopharmacology. 2008 Apr;16(2):113. Available from:


Dhillon S, Yang LP, Curran MP. Bupropion: a review of its use in the management of major depressive disorder. Drugs. 2008 Apr;68:653-89. Available from:


Predictable SE, Laurencic G, Malone D. Side effects of antidepressants: an overview. Cleveland Clin J Med. 2006 Apr;73(4):351.Available from:

Find a supportive therapist who can help with Depression.

Discover the convenience of BetterHelp, an online therapy platform connecting you with licensed and accredited therapists specialized in addressing issues such as depression, anxiety, relationships, and more. Complete the assessment and find your ideal therapist within just 48 hours.


AskYourPharm is user-supported. We may earn a commission if you sign up for BetterHelp’s services after clicking through from this site