Does the combination of Wellbutrin and Buspar have good reviews? 

Does the combination of Wellbutrin and Buspar have good reviews?

Wellbutrin (Bupropion) and Buspar (Buspirone) have good reviews and are often prescribed together. Wellbutrin is an antidepressant that is used to treat major depressive disorder and seasonal affective disorder, and Buspar is an anxiolytic used to treat anxiety disorders.

The addition of Buspar in antidepressant therapy is generally considered beneficial, especially in people who are resistant to antidepressant monotherapy (1). However, individual responses do vary. 

Although this combination can help manage the symptoms of both anxiety and depression, it should not be taken if not prescribed (2). Each individual is unique and what works for one may not work for another. So, make sure you properly follow your doctor’s directions.

What have people experienced so far?

The combination of Wellbutrin and Buspar has worked wonders for some but worked not so well for others. Amanda, a 47-year-old user stated:

‘I have switched a lot of antidepressants and I can’t even remember exactly how many I have used since my depression was diagnosed, but I can tell you which one changed my life. I also struggled with finding the right doctor because I kept complaining about antidepressants and most doctors did not seem to care.’

She continued:

“Finally I came across this great doc who put me on the combination of Wellbutrin and Buspar, and bam! It was amazing. I did not find it heavy on my body and suffered from minimal side effects. They worked so well together that I started feeling like myself again in just a few months. It made me wonder why I didn’t find this combination earlier and wasted so many years with terrible antidepressants.”

Another user of this combination, 39-year-old Mathew shared his story. He stated:

“My doctor put me on Wellbutrin when I failed to respond well to Zoloft and it made me gain a tremendous amount of weight. I had high hopes for Wellbutrin and I also expected to lose some of the extra weight I gained. I kept taking Wellbutrin properly and I did lose weight and my depression did start to get better, but I suffered from a nightmare of a side effect.”

Mathew continued:

“I started biting my tongue and grinding my teeth. It was not so bad at first, but as my treatment continued, this habit got so bad that my tongue started bleeding and my teeth aching. That’s when my doctor put me on Buspar, and I tell you what – this medication saved my life! My teeth grinding started to go away and Buspar worked well with Wellbutrin to help my anxiety and depression.”

This review indicates that Buspar when used in combination with Wellbutrin can prevent some of the side effects this antidepressant causes. However, this combination may not work well for everyone. Another user, 28-year-old Lizzie stated:

“Wellbutrin and Buspar have been my biggest nightmare so far when it comes to antidepressants. I read so many good things about it so I had high hopes when my doc put me on this combination, but it did not work well for me. Nothing about it was worth it, and the side effects were too many to handle. I guess these meds work differently in each one of us, and it just wasn’t the best for me.

Potential side effects of the combination of Wellbutrin and Buspar

Wellbutrin and Buspar are associated with some side effects, that may vary from person to person and can depend on the doses prescribed. Some of the potential side effects include:

  • Nausea
  • Vomiting
  • Indigestion
  • Dizziness- common with Wellbutrin 
  • Lightheadedness
  • Headache
  • Insomnia- common with both Wellbutrin and Buspar
  • Dry mouth
  • Increased anxiety
  • Restlessness
  • Changes in appetite
  • Weight loss or weight gain
  • Tremors and seizures- more common with Wellbutrin
  • Muscle twitches

Final words

Antidepressants affect every individual differently. Determining the best antidepressant or combination of antidepressants is a trial and error process, and some people may take multiple attempts until they find the best-suited antidepressant. 

Make sure you monitor your side effects and report them to your healthcare provider. If this combination is not the best possible option for you, your doctor will safely switch you to another one. Just make sure you don’t make any changes to your prescription on your own. 

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Dimitriou EC, Dimitriou CE. Buspirone augmentation of antidepressant therapy. J Clin Psychopharmacol. 1998 Dec;18(6):465-9. doi: 10.1097/00004714-199812000-00009. PMID: 9864079. Available from:


Fava M. The combination of buspirone and bupropion in the treatment of depression. Psychother Psychosom. 2007;76(5):311-2. doi: 10.1159/000104708. PMID: 17700052. Available from:

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