Does Prozac cause joint aches? (3+ tips)

In this article, we will answer the question “Does Prozac cause joint aches?”. We will discuss the factors contributing to joint aches while on Prozac and also some tips and strategies to help minimize joint aches while taking this medication.

Does Prozac cause joint aches?

Yes, Prozac tends to cause joint aches in some individuals. Although it is not a commonly reported side effect of this medication, various cases have been reported.

Prozac (also known as Fluoxetine) is an antidepressant medication belonging to the class of selective serotonin reuptake inhibitors (SSRIs) and is approved by the FDA for the treatment of depressive illnesses (1).

Prozac is used to treat illnesses like major depressive disorder (MDD), obsessive-compulsive disorder (OCD), bulimia nervosa and panic disorder. It is used in combination with olanzapine for the management of treatment-resistant depression and depressive disorders related to bipolar I disorder (1).

How does Prozac cause joint aches?

Although, the exact mechanism of Prozac in causing joint aches has not yet been understood some experts link it to the effects of depression, which may cause chronic inflammation and hence the occurrence of joint aches and pains.

More research studies are required to assess the exact mechanism behind the occurrence of joint aches and pain while taking Prozac. However, if you do feel any joint or muscle aches while taking Prozac, make sure to tell your healthcare provider about your symptoms.

What does research suggest?

As Prozac-induced joint pain is a rare and most often self-limiting side effect, only a few case studies of individuals reporting joint pain while using Fluoxetine have been reported. Some studies are as follows:

A review was published, which reported the occurrence of a potentially serious rash associated with joint pain in 14 individuals taking Fluoxetine. The discontinuation of Fluoxetine treatment resolved the problem in most cases (4).

A case of a 15-year-old girl was reported who was given Fluoxetine 20mg for the treatment of her condition. She also developed a rash and joint pain which resolved almost one week after discontinuation of treatment (5). 

What factors contribute to joint aches while on Prozac?

Factors that may contribute to joint aches while on Prozac include the following:


Some individuals may have a comorbidity of arthritis while undergoing treatment for depression. There have been many cases where depression and arthritis are both interlinked and may exacerbate one another.


Elderly individuals tend to have weaker bones and joints, which may cause an increased risk of joint aches.

Low bone density

Individuals who have low bone density can also experience joint aches while using Prozac or any other medication.

Nutritional deficiencies

Unhealthy eating habits can cause nutritional deficiencies of essential nutrients. If such deficiencies are not corrected they can lead to muscle and joint aches.

Individual susceptibility

Each individual has unique characteristics that may determine their response to Prozac. Some individuals may tolerate the medication quite well, while others may experience side effects like joint and muscle pain.

How to manage joint aches while on Prozac?

Some tips and strategies can be used to alleviate or minimize joint aches while taking Prozac. These are as follows:

  • Apply a hot or cold compress: Applying a hot or cold compress to the affected area or joint can help in immediate relief of the pain.
  • Get a massage: Sometimes massage therapies can help relax muscles and provide relief to the irritated joint.
  • Get enough rest: Getting enough rest is crucial for the body. Joint aches can also arise due to overworked joint muscles.
  • Acupuncture therapy: Acupuncture techniques if done properly, can help relieve joint and muscle pain.
  • Meditation: Yoga and meditation are not only good for the mind, but the body as well. A relaxed mind has a more positive approach towards healing.
  • Exercise: An adequate amount of daily exercise is important for the well-being of the body. Exercise and different stretching techniques can help with various aches and pains.
  • Dietary factors: A healthy and nutritious diet can help provide your body with essential nutrients that are needed for healthy bones and joints.
  • Add turmeric: Adding turmeric to your diet can be beneficial as it has anti-inflammatory properties that can help with joint aches.
  • Manage weight: If you are overweight you should try to manage your weight within an acceptable range. Excess weight can cause unnecessary pressure on your joints, causing them to ache.

What to do if Prozac causes joint aches?

If Prozac causes joint aches and they become discomforting or too painful for you, make sure to communicate this to your healthcare provider. They will assess your situation and find out the cause of your symptoms.

If the joint aches persist you can also request your healthcare provider for alternative antidepressant medications for your depressive illness. Your doctor will suggest the option best suited for your condition.

Keep in mind that you should not start or stop any medication without the guidance of your healthcare provider.

What are some other side effects of Prozac?

Prozac is also associated with many other side effects. Some commonly reported adverse events are nausea, rash, fatigue, headache, drowsiness, insomnia, nightmares, anorexia, anxiety, dry mouth, flu-like symptoms, diarrhoea, decreased libido, sweating, pharyngitis, nervousness, somnolence, sinusitis, tremors and excessive yawning (1,2).

Some less common or rare side effects associated with the use of Prozac are abnormal bleeding, suicidal ideation and behaviours, serotonin syndrome, activation of mania, seizures, changes in urination, decreased appetite, weight loss, vision changes, cognitive and motor impairment, joint aches and pain, change in taste, hair loss, hyperactivity, heart palpitations and increased heartbeat (1,2).

It is important to inform your healthcare provider and keep a record of any side effect that you  experience while taking Prozac

To the best of my knowledge, Prozac can cause joint aches and pain as a side effect. Although this is a rarely reported and mostly self-limiting side effect but can also become severe. As each individual is different, the response to Prozac may also vary from one person to the other.

If you feel that Prozac is causing joint aches or discomfort you should immediately seek medical advice regarding your condition. Do not abruptly stop taking Prozac or start any painkillers to help you with the pain. Always consult your healthcare provider and follow his recommendations.

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The Food and Drug Administration (FDA). HIGHLIGHTS OF PRESCRIBING INFORMATION. PROZAC® (fluoxetine capsules) for oral use. Available from: 


Sohel AJ, Shutter MC, Molla M. Fluoxetine. [Updated 2022 Jul 4]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2023 Jan-. Available from:


Morton WA, SONNE SC, LYDIARD RB. Fluoxetine-associated side effects and suicidality. Journal of clinical psychopharmacology. 1993 Aug 1;13(4):292-5.


Cooper GL. The safety of fluoxetine-an update. The British Journal of Psychiatry. 1988 Sep;153(S3):77-86.


Esaa FS, Shah PR, Beck LA. Serum sickness secondary to fluoxetine. SKIN Natl Soc Cutaneous Med. 2018 Sep 7;2:340-2.

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