Does fluoxetine make you shaky? (+3 findings)

In this article, we will discuss whether or not fluoxetine makes you shaky, research studies on the association between fluoxetine use and tremors, factors that can contribute to fluoxetine-induced tremors, and what to do if fluoxetine causes tremors.

Does fluoxetine make you shaky?

Yes, fluoxetine can make you shaky. However, individuals differ in their response to medications, and not everyone taking fluoxetine will experience tremors. (1)

Fluoxetine is an antidepressant medication that is sold under the brand name Prozac. It belongs to the class of drugs known as SSRIs (Selective Serotonin Reuptake Inhibitors). Fluoxetine functions by inhibiting the reuptake of serotonin in the brain. Thereby, increasing serotonin concentration in the body. (2)

Although the exact cause of SSRI-induced tremor is unknown, it has been suggested that serotonergic receptor stimulation is the cause.

Additionally, it has been suggested that excessive stimulation of the inferior olivary and red nuclei may cause thalamic and cortical neurons to become overstimulated, which may cause tremors. It has been suggested that serotonin may play a role in the development or aggravation of tremors. (3)

What does research suggest?

According to a research study, it was reported that 21 patients including males and females with a mean age of 42.4 years experienced minor tremors after taking fluoxetine at a mean dose of 25.7 mg per day. The average latency period for the onset of tremors was 54.3 days.

Tremors improved and gradually faded away after fluoxetine was discontinued. The study concluded that the mechanism of action of fluoxetine which involves the engagement of the red and inferior olivary nuclei through projections to the thalamus and spinal cord may induce tremors in certain individuals. (4)

Research indicates that over 20% of individuals on SSRIs such as fluoxetine experience tremors even in the absence of prior tremor history. These tremors might be mild and unobtrusive to day-to-day activities, or they can be more severe and impair an individual’s capacity to function properly. (3)

What factors can contribute to fluoxetine-induced shakiness?

There are several factors that can contribute to fluoxetine-induced shakiness such as: (4)

Medication dose: High fluoxetine dosages can cause tremors.

Underlying medical conditions: Certain medical conditions such as MS (Multiple Sclerosis), Parkinson’s disease, diabetes, liver diseases, kidney diseases, hyperthyroidism, and neurological disorders may induce tremors while using fluoxetine.

Concurrent medications: Certain medications such as corticosteroids, antipsychotics, and anti-asthma medications may induce tremors while taking fluoxetine.

Lifestyle factors: Caffeine, stress, anxiety, regular exposure to neurotoxins and heavy metals, and fatigue may all induce tremors while taking fluoxetine.

Age: The elderly population is more prone to experience tremors than the younger population.

What should you do if fluoxetine causes shakiness?

If you experience tremors while taking fluoxetine, consult your healthcare provider about reducing your medication dose or switching to an alternative with fewer adverse events such as:

Mirtazapine: It is an atypical antidepressant that is sold under the brand name Remeron. It can be used instead of fluoxetine and was proven to be effective in treating ET (Essential tremor) in certain individuals. (5)

Sertraline: It is an SSRI antidepressant that is sold under the brand name Zoloft. Sertraline can cause fewer tremors and can be well-tolerated by certain individuals.

Your healthcare provider will properly assess your situation and determine whether the tremor is caused by fluoxetine or by other underlying neurological disorders or concurrent medications. They will then take the best course of action accordingly.

If your tremors are due to fluoxetine use, your healthcare provider might also recommend some vitamins such as vitamin B2 (Riboflavin) and Vitamin B12. These vitamins can help reduce tremors and strengthen your nerves while taking fluoxetine.

Based on my knowledge and research, fluoxetine can cause tremors in certain individuals as a side effect of its use. If you experience persistent tremors while taking fluoxetine, consult your healthcare provider about reducing your dose or switching to an alternative with fewer adverse events.

Was this helpful?

Thanks for your feedback!



Fluoxetine (Oral Route) Side Effects – Mayo Clinic [Internet]. 2019. Available from: 


Medline Plus. Fluoxetine: MedlinePlus Drug Information [Internet]. 2019. Available from:


Morgan JC, Kurek JA, Davis JL, Sethi KD. Insights into Pathophysiology from Medication-induced Tremor. Tremor and Other Hyperkinetic Movements [Internet]. 2017 Nov 22;7(442). Available from:


Tremor | National Institute of Neurological Disorders and Stroke [Internet]. Available from:


Uccellini D, Grampa G, La Spina I, Nasuelli D, Neromante I, Politini L, et al. Mirtazapine in the treatment of essential tremor: an open-label, observer-blind study. Neuropsychiatric Disease and Treatment [Internet]. 2006 Mar 1 [cited 2023 Nov 21];2(1):95–100. Available from:

Find a supportive therapist who can help with Depression.

Discover the convenience of BetterHelp, an online therapy platform connecting you with licensed and accredited therapists specialized in addressing issues such as depression, anxiety, relationships, and more. Complete the assessment and find your ideal therapist within just 48 hours.


AskYourPharm is user-supported. We may earn a commission if you sign up for BetterHelp’s services after clicking through from this site