Does Prozac cause a burning throat sensation?(3+ symptoms)

In this article, we will discuss whether Prozac causes a burning throat sensation. We will also discuss research studies on this subject and briefly mention some ways that can help manage burning throat sensation while on Prozac.

Does Prozac cause a burning throat sensation?

Yes, Prozac is known to cause a burning throat sensation especially if you are new to the medication or if your medication dosage has been increased (1). Although it is not that common, people do report experiencing a burning throat sensation now and then.

In some cases, this side effect subsides as your body adjusts to the medication’s dosage and with proper administration of the drug. However, if your Burning sensation with Prozac gets severe, you should reach out to your healthcare provider as soon as possible.

What does research suggest?

Although research on this specific side effect is limited, the incidence of burning throat sensation with Prozac varies among individuals. The exact mechanism by which Prozac contributes to this side effect is not fully understood (1,2).

It is believed that Prozac can affect the gastrointestinal tract, including the lower oesophagal sphincter(LES) (1,5). A disruption of the LES can lead to acid reflux symptoms which sometimes patients refer to as a burning throat sensation (1,2).

Additionally, the administration of oral Prozac may cause an allergic reaction that presents as an irritated burning throat sensation. This presentation is due to inflammation of the oesophagus (oesophagitis) caused by the medication’s ingredients (4).

Some studies have also suggested a phenomenon known as Pill oesophagitis. It occurs when a pill releases its noxious contents along the walls of the oesophagus causing damage and irritation (1). This may occur when the pill’s active ingredient is Fluoxetine Hydrochloride (3).

Studies have also shown that a burning throat sensation may occur when you incorrectly ingest Prozac. When you incorrectly ingest Prozac, the pill might get stuck in your throat. Prolonged exposure of your throat muscles to the pill may cause pain and inflammation causing a burning sensation.

What to do if you experience a Prozac-induced burning sensation in your throat?

It is important to consult your doctor if you experience a burning throat sensation. Your healthcare provider will assess your symptoms, determine the cause of this side effect and guide you on how to manage this side effect.

Your doctor may discontinue your treatment on Prozac or switch you to a liquid preparation of Prozac to reduce the occurrence of this side effect. Additionally, your doctor may also adjust your dosage to reduce this side effect. If the burning throat sensation is severe your doctor may also switch you to an alternative medication (3).

Your doctor may also prescribe short-term treatment with an acid reducer to manage the suspected throat-burning sensation induced by acid reflux. They will recommend Proton Pump Inhibitors such as Omeprazole for a few days until your body adjusts to Prozac.

Additionally, your doctor may recommend oral sucralfate to act as a protective barrier and prevent throat burning sensation while on Prozac (3).

Important tips to manage Prozac-induced burning throat sensation

Prozac-induced burning throat sensation normally goes away as your body adjusts to the medication. However, you can try some things to avoid and reduce the symptoms. a few important tips to consider are:(2)

  • Taking the medication with adequate water and with meals to prevent the likelihood of Pill oesophagitis occurring
  • Drink plenty of water
  • Taking the medication while sitting upright
  • Avoid irritating beverages and food (spicy food)
  • Taking probiotics to protect and improve your stomach health
  • Gargling with warm water may soothe the burning throat sensation
  • Monitor symptoms and report them to your doctor
  • Follow your doctor’s recommendations for managing this side effect


A Prozac-induced burning throat sensation can be quite uncomfortable. It is important to work closely with your healthcare provider while experiencing this side effect. Your healthcare provider will determine the cause of the burning throat sensation and provide you with guidance on how to manage it.

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Wani AM, Shiekh AG, Hussain WM, Miamini WA, Khoujah AM, Zayyani NR. Fluoxetine-induced pill oesophagitis. BMJ Case Reports [Internet]. 2011 Jul 4 [cited 2023 Sep 17];2011:bcr0920103333. Available from:



Saleem F, Sharma A. Drug-Induced Esophagitis [Internet]. PubMed. Treasure Island (FL): StatPearls Publishing; 2023 [cited 2023 Sep 17]. Available from:



PubChem. Fluoxetine hydrochloride [Internet]. Available from:






Guzel T, Mirowska-Guzel D. The Role of Serotonin Neurotransmission in Gastrointestinal Tract and Pharmacotherapy. Molecules. 2022 Mar 3;27(5):1680.


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